Dr. Hyatt conducts research into the chemistry of naturally occurring organic compounds having antioxidant activity. In particular, he is involved with isolation, purification, and structural modification of the rare members of the vitamin E family of compounds (tocols). He also does total synthesis of compounds in this class, and of unnatural analogs and homologs of natural antioxidants. In collaborations with biomedical researchers, the application of these compounds to the management of chronic diseases such as diabetes and inflammatory bowel disease is under study. Dr. Hyatt also is active in research on the antiradiation activity of certain tocols.
Department of Chemistry
P. O. Box 70695
East Tennessee State University
Johnson City, TN 37614-0695
Work Phone: 423-262-6333
Home Phone: 423-343-0067
BS, Chemistry, Wake Forest University 1970
Ph.D., Organic Chemistry, The Ohio State University 1973
Postdoctoral Fellow, Harvard University 1975
Research Laboratories, Eastman Chemical Co. 1975-2004
East Tennessee State University, 2004-present
John A. Hyatt* and Chad Skelton, A Kinetic Resolution Route to the (S)-Chromanmethanol Intermediate for Synthesis of the Natural Tocols., Tetrahedron Asymmetry 8, 523 (1997).
John A. Hyatt* and Mellisa Phillips, Preparation of Selectivity Deuterated gamma-Tocotrienol. J. Labelled Compounds Radiopharmaceuticals 42, 1245 (1999).
Marion Franks, John A. Hyatt, and Mark Welker*, Diels-Alder Reactions of Epoxybutene Derivatives and Subsequent Synthetic Manipulation of the Cycloadducts. Org. Process Res. Dev. 5, 514 (2001).
John A. Hyatt*, Gregg Kottas, and Janet Effler, Development of Synthetic Routes to D,L-alpha-Tocopherol (Vitamin E) from Biologically Produced Geranylgeraniol. Org. Process Res. Dev. 6, 782 (2002).
John A. Hyatt*, A Novel and Convenient Synthesis of 4-Halobutyraldehyde Acetals. Org. Prep. Procedures Int. 36, 487 (2004)
Eva-Maria Collnot, Christiane Baldes, Michael Wempe, John A. Hyatt, Lisa Navarro, Kevin J. Edgar, Ulrich Schaefer, and Calus-Michel Lehr*, Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayers. Journal of Controlled Release 11, 35 (2006).
E. Couladouros*, V. Moutsos, M. Lampropoulou, and John A. Hyatt*, Total Synthesis of beta-, gamma-, and delta-Tocotrienols. Journal of Organic Chemistry, submitted for publication.
E. Collnot, C. Baldes, M. Wempe, R. Kappl, J. Huttermann, John A. Hyatt, K. Edgar, U. Schafer, and C. Lehr, "Mechanism of Inhibition of P-Glycoprotein Mediated Efflux by Vitamin E TPGS: Influence on ATPase Activity and Membrane Fluidity". Molecular Pharmaceutics 4( 3), 465-474 (2007).
E. Collnot, C. Baldes, M. Wempe, John A. Hyatt, L. Navarro, K. Edgar, U. Schaefer, and C. Lehr, "Influence of Vitamin E TPGS Poly(ethylene glycol) Chain Length on Apical Efflux Transporters in Caco-2 Cell Monolayers". Journal of Controlled Release 111, 35-40 (2006).
E. Couladouros, V. Moutsos, M. Lampropoulou, J. Little, and John A. Hyatt, "A Short and Convenient Chemical Route to Optically Pure 2-Methyl Chromanmethanols. Total Asymmetric Synthesis of beta-, gamma-, and delta-Tocotrienols. Journal of Organic Chemistry 72, 6735-6741 (2007).
John A. Hyatt, "Convenient Preparation of 2,7,8-Trimethyl-6-hydroxychroman-2-carboxylic Acid (gamma-Trolox)". Synthetic Communications 38, 8-14 (2008).
C. Constantinou, John A. Hyatt, P. Vraka, G. Papas, C. Neophytou, V. Hadjivassiliou, and A. Constantinou, "Regulation of Caspase-independent Cell Death by Vitamin E natural Compounds and Synthetic Derivatives". in press, Cancer Research.