The College of Arts and Sciences includes two museums and one gallery:

The Reece Museum A campus history project initiated in the late 1920s created a repository that ultimately emerged as the B. Carroll Reece Memorial Museum. The museum collection grew as a part of the university's library, and in 1965, the collection was transferred to its present location in the renovated building that had most recently housed the art department. The Art Department's permanent collection of works of art became the core of the Reece Museum's fine arts collection.

The ETSU and General Shale Brick Natural History Museum The East Tennessee State University and General Shale Brick Natural History Museum and Visitor Center at the Gray Fossil Site is dedicated to understanding, preserving and interpreting biodiversity of the Southern Appalachians through time, using an interdisciplinary approach. The Natural History Museum seeks to understand and interpret the Gray Fossil Site for people of all ages and origins through scientific research, curriculum-bases educational programs, and informal hands-on experiences. 

The Slocumb Galleries The Slocumb Galleries under the Department of Art & Design at the ETSU College of Arts and Sciences provide year-round exhibition program featuring BFA and MFA Graduation Shows and the Visiting Artists Exhibition & Lecture Series with the aims to encourage the development of the visual arts in support of the academic experience at ETSU and the surrounding communities. The galleries’ mission is to provide venue and access to contemporary art by organizing innovative exhibitions that promote artistic excellence, cultural awareness and creative thinking.

The Reece Museum
The Reece Museum is part of the Center for Appalachian Studies and Services.