Organic Chemist
Assistant Professor
Ph.D.,
Phone: 423-439-6917
Fax: 423-439-5835
Address:
Brown Hall, 401
Department of Chemistry
P.O. Box 70695
Research Interests:
Research focus is to use organic chemistry to solve biological problems. Research areas include:
1. Medicinal chemistry, covering the synthesis of small molecules and evaluation in the inhibition and killing of human prostate and melanoma cancer cells. As an example, the binding of human serum albumin by resveratrol and derivatives were investigated using fluorescence spectroscopy
2. Supramolecular chemistry, including synthesis and characterization of fluorescent receptors for molecular recognition of biologically important molecules. One example is using a receptor RE-1 to bind 9-butyladenine.
3. Bioorganic chemistry, involving synthesis and purification of bio-functional molecules from herbal medicines and fossil wood. For instance, perylene has been purified and characterized from fossil wood, which is 4-6 million-year-old. Perylene is used as a fluorescent marker in biological systems.
Professional Experience:
Postdoctoral Fellow, CARB,
Postdoctoral Fellow, John Hopkins University, 2001-2005
Research Faculty, John Hopkins University, 2005-2006
Assistant Professor, East Tennessee State University, 2006-present
Recent Publications:
1.
Jiang, Y.L. Design,
synthesis and spectroscopic studies of resveratrol aliphatic acid
ligands of human serum albumin.
Bioorganic Medicinal
Chemistry, 2008,
16(12), 6406-6414.
2. Xiao, M.; Zhu, B.-K; Jiang, Y.L. Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors. Letters in Drug Design & Discovery, 2008, 5, 108-110.
3.
Xiao, M.;
Yang, H.;
Klein, S.M.;
Muenyi, C.M.; Stone,
W.L.; Jiang, Y.L.
Facile Synthesis of
Anticancer Drug NCX 4040 in Mild Conditions.
Letters in Organic
Chemistry, 2008, 5,
510-513.
4. Klein, S.M.; Zhang, C.; Jiang, Y.L. Simple synthesis of fresh alkyl iodides using alcohols and hydriodic acid. Tetrahedron Letters, 2008, 49, 2638-2641.
5. Lamale, B.; Henry, W.P.; Daniels, L.M.; Zhang, C.; Klein, S.M.; Jiang, Y.L. Synthesis and Crystal Structures of Fluorescent Receptors for 9-Butyladenine Tetrahedron, 2008, accepted for publication.
6. Jiang,
Y.L.; Liu, Y.S. Simple and
Convenient Determination of Perylene Preserved in the Late Neogene Wood
from