Organic Chemist
Assistant Professor
Degree: Ph.D., The
University of Adelaide, Australia
Phone: 423-439-6917
Fax: 423-439-5835
Address:
Brown Hall, S401
Department of Chemistry
P.O. Box 70695
East Tennessee State University
Johnson City, TN 37614
Research Interests:
The focus is to use organic chemistry to solve biological problems. The research will cover organic chemistry, enzymology, drug discovery, chemical biology, biochemistry, molecular biology, nucleic acids research, protein chemistry and engineering, signal transduction and regulation.
Professional Experience:
Postgraduate student, The University of Adelaide, 1996-1999
Postgraduate Fellow, Center for Advanced Research in Biotechnology, University of Maryland and National Institute of Standard Technology, 1999-2001
Postdoctoral Fellow, John Hopkins University School of Medicine, 2001-2003
Postdoctoral Fellow, John Hopkins University, Department of Chemistry, 2003-2005
Postdoctoral Fellow, John Hopkins School of Medicine, 2004-2005
Faculty Research Associate, John Hopkins University School of Medicine, 2005-2006
Assistant Professor, Department of Chemistry, East Tennessee State University, 2006-present
Selected Recent Publications:
1. Jiang, Y. L.; Chung S.; Krosky, D.; Seiple L.; Stivers, J. T. Synthesis and high-throughput evaluation of triskelion uracil libraries for inhibition of human dUTPase and UNG2. Bioorg. Med. Chem. 2006, 14, 5666-5672.
2. Jiang, Y. L.; Krosky, D.; Seiple L.; Stivers, J. T. Uracil Directed Ligand Tethering An Efficient Strategy for Human Uracil DNA Glycosylase (UNG) Inhibitor Development, J. Am. Chem. Soc. 2005, 127(49), 17412-17420.
3. Jiang, Y. L,; Wiederholt, C. J.; Patro, N. J.; Haraguchi, K.; Greenberg, M. M. Synthesis of Oligonucleotides Containing FapydG (N6-(2-Deoxy-α,β-D-erythropentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine) Using a 5'-Dimethoxytrityl Dinucleotide Phosphoramidite. J. Org. Chem. 2005, 70(1), 141-149.
4. Jiang, Y. L.; McDowell, L. M.; Poliks, B.; Studelska, D. R.; Cao, C.; Potter, G. S.; Schaefer, J.; Song, F.; Stivers, J. T. Recognition of an Unnatural Difluorophenyl Nucleotide by uracil DNA Glycosylase, Biochemistry 2004, 43(49), 15429-15438.
5. Jiang, Y. L.; Cao, C.; Stivers, J. T.; Song, F.; Ichikawa, Y. The Merits of Bipartite Transition-State Mimics for Inhibition of Uracil DNA Glycosylase. Bioorganic Chemistry 2004, 32 (4), 244-262.
6. Cao, C.; Jiang, Y. L.; Stivers, J. T.; Song, F. Dynamic opening of DNA during the enzymatic search for a damaged base. Natural Structural & Molecular Biology 2004, 11(12), 1230-1236.
7. Jiang, Y. L.; Stivers, J. T. Novel Epimerization of Aromatic C-nucleosides with Electron withdrawing Substituents with Trifluoroacetic Acid-Benzenesulfonic Acid Using Mild Conditions, Tetrahedron Lett. 2003, 44, 4051-4055.
8. Kwon, K.; Jiang, Y. L.;Stivers, J. T. Rational Engineering of a DNA Glycosylase Specific for an Unnatural Cytosine: Pyrene Base Pair, Chemistry & Biology 2003, 10, 351-359.
9. Jiang, Y. L.; Drohat, A. C.; Ichikawa, Y.; Stivers, J. T. Probing the Limits of Electrostatic Catalysis by Uracil DNA Glycosylase Using Transition State Mimicry and Mutagenesis. J. Biol. Chem. 2002, 277, 15385-15392.
10. Crisp, G. T.; Jiang, Y. L. Intramolecular hydrogen bonding studies for a series of dipurinyl-2,6-pyridinedicarboxamides. Tetrahedron 1999, 55(2), 549-560.