Richard M. Kostrzewa, PhD., Dr.h.c.
Professor, Department of Biomedical Sciences
Curriculum Vita

Contact Information:

Department of Biomedical Sciences
Quillen College of Medicine
East Tennessee State University
PO Box 70577
Johnson CIty, TN 37614


B.S. (Chemistry), M.S. (Pharmacology): Philadelphia College of Pharmacy & Science
Ph.D. (Pharmacology): University of Pennsylvania, Philadelphia PA
Dr.h.c.: Medical University of Silesia, Katowice, Poland

Professional Background:

Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA, 1971 75
Adjunct Asst. Prof., Pharmacology, Tulane University Medical Center, New Orleans, LA, 1974 76
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans, LA, 1974 77
Assistant Professor of Physiology, Louisiana State University Medical Center, New Orleans, LA, 1975 78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, 1984 present; Associate Professor, 1978 84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003

Research / Teaching Interest:

  • Dopamine receptor supersensitivity
  • Dopamine systems relating to ADHD, Parkinson Disease, Tardive Dyskinesia
  • Highly selective neurotoxins



Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, P Nowak and R Brus (2008) Pharmacological models of ADHD. J. Neural Transm. 115, 287-298. 

Kostrzewa RM, L Antkiewicz-Michaluk and F Fornai (2010) Dopaminergic nerves as targets for neurotoxins, In: Neurotoxicology, Target Organ Toxicity Series, 3rd Edition (Harry J and H Tilson, Eds.) (Informa Health Care, New York, NY), pp. 112-137. [ISBN: 9781420054873] 

Nowak P, RA Kostrzewa, D Skaba and RM Kostrzewa (2010) Acute L-DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of Parkinsonian rats. Neurotox. Res. 17(3), 299-304. 

Kostrzewa RM, Kostrzewa JP, Kostrzewa RA, Kostrzewa FP, Brus R, Nowak P (2011) Stereotypic progressions in psychotic behavior. Neurotox. Res. 19: 243-252. 

Archer T, Kostrzewa RM (2012) Physical exercise alleviates ADHD symptoms: regional deficits and development trajectory. Neurotox Res. 21(2):195-209.

Kostrzewa RM, FP Kostrzewa (2012) Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in rats that were quinpirole-primed during postnatal ontogeny. Neurotox Res. 21(2):231-235. 

Brown RW, Maple, AM, Perna MK, Sheppard AB, Cope ZA, Kostrzewa, RM (2012?) Schizophrenia and substance abuse comorbidity: Nicotine addiction and the neonatal quinpirole model. Dev. Neurosci. Review. (accepted, Apr 2012) 

Kostrzewa RM (2013) Tardive dyskinesia: outcome of antipsychotic treatment and brain damage? Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York. (accepted Oct 10, 2012) 

Chen J, RM Kostrzewa, X Xu (2013) “Necroptosis, a potential therapeutic target for neurological disorders”. In Handbook of Neurotoxicity (Kostrzewa RM, Editor) (Springer, New York NY), Section on Selective Neurotoxins (RM Kostrzewa, Section Editor).

Bałasz M, R Szkilnik, R Brus, J Malinowska-Borowska, S Kasperczyk, D Nowak, RM Kostrzewa, P Nowak (2014) Perinatal manganese exposure and hydroxyl radical formation in rat brain. Neurotox Res. (in press)