Kostrzewa

Richard M. Kostrzewa, PhD., Dr.h.c.
Professor, Department of Biomedical Sciences
Curriculum Vita



Contact Information:

Department of Biomedical Sciences
James H. Quillen College of Medicine
East Tennessee State University
PO Box 70577
Johnson CIty, TN 37614
423-439-6321



Education:

B.S. (Chemistry), M.S. (Pharmacology): Philadelphia College of Pharmacy & Science
Ph.D. (Pharmacology): University of Pennsylvania, Philadelphia PA
Dr.h.c.: Medical University of Silesia, Katowice, Poland

Professional Background:

Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA, 1971 75
Adjunct Asst. Prof., Pharmacology, Tulane University Medical Center, New Orleans, LA, 1974 76
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans, LA, 1974 77
Assistant Professor of Physiology, Louisiana State University Medical Center, New Orleans, LA, 1975 78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, 1984 present; Associate Professor, 1978 84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003


Research / Teaching Interest:

  • Dopamine receptor supersensitivity
  • Dopamine systems relating to ADHD, Parkinson Disease, Tardive Dyskinesia
  • Highly selective neurotoxins

 

Publications:

Kostrzewa RM (Editor-in-Chief) Handbook of Neurotoxicity, Springer New York, Heidelberg, Dordrecht, London, 2014.
ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4
Kostrzewa RM (2014) Survey of Selective Neurotoxins (chapter title), in Section on Selective Neurotoxins, in Handbook
of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, Heidelberg, Dordrecht, London, 2014, pp 3-67. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_53.
Kostrzewa JP, RM Kostrzewa (2014) p-Chloroamphetamine potentiated dopamine release into in vivo microdialysates of partially
serotonin-denervated neostriatum in an animal model of Parkinson’s disease: implications for treatment of Parkinson’s disease. Neurochem Res. (pending).
Brown RW, Maple AM, Perna MK, Sheppard AB, Cope ZA, Kostrzewa, RM (2012) Schizophrenia and substance abuse comorbidity: 
Nicotine addiction and the neonatal quinpirole model. Dev Neurosci. 34(2-3), 140-151. Epub 2012 Jul 6. Review.
Kostrzewa RM, FP Kostrzewa (2012) Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in
rats that were quinpirole-primed during postnatal ontogeny.  DOI: 10.1007/s12640-011-9268-5. Neurotox Res. 21(2):231-235. Epub 2011 Aug 19. PMID: 21853388.
Kostrzewa RM, Kostrzewa JP, Kostrzewa RA, Kostrzewa FP, Brus R, Nowak P (2011) Stereotypic progressions in psychotic
behavior. Neurotox. Res. 19: 243-252. DOI: 10.1007/s12640-010-9192-0 
Nowak P, RA Kostrzewa, D Skaba and RM Kostrzewa (2010) Acute L-DOPA effect on hydroxyl radical- and DOPAC-levels in
striatal microdialysates of Parkinsonian rats. Neurotox. Res. DOI: 10.1007/s12640-009-9105-2. online, Sept. 4, 2009. Neurotox. Res. 17(3), 299-304. 
Kostrzewa RM (2010) Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment, In: 5-HT2C Receptors
in the Pathophysiology of CNS Disease (Di Giovanni G, E Esposito, and V Di Matteo, Eds.) (Humana Press/ Springer Science+Business Media, New York), pp. 383-393. ISBN: 978-1-60761-940-6. DOI: 10.1007/9780-1-60761-941-3. 
Kostrzewa RM, JP Kostrzew, R Brown, P Nowak and R Brus (2008) Dopamine receptor supersensitivity: development, mechanisms,
Kostrzewa RM, JP Kostrzew, R Brown, P Nowak and R Brus (2008) Dopamine receptor supersensitivity: development, mechanisms,
Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, P Nowak and R Brus (2008) Pharmacological models of ADHD. J. Neural Transm. 115, 
287-298.