Fred E. Hossler

CURRICULUM VITAE

 
Office Address:
Department of Biomedical Sciences
P.O. Box 70582
James H. Quillen College of Medicine
East Tennessee State University
Johnson City, Tennessee 37614-0582
    Telephone: (423) 439-2011
FAX: (423) 439-2017
E-mail: or
 
Academic Training
Institution Location   Major   Degree   Date
Muhlenberg College Allentown, PA   Biology   B.S.   1963
 
Penn. State Univ. State College, PA   Microbiology   M.S.   1965
 
Univ. of Colorado
Medical Center
Denver, CO   Pathobiology   Ph.D.   1971
 
Yale University New Haven, CT   Cell Biology   Postdoc.   1971-1974
 
Faculty Positions - Academic Appointments
Institution   Department   Status   Dates
Louisiana State University
 Medical Center
  Anatomy   Asst. Professor   1974-1979
 
Louisiana State University
 Medical Center
  Anatomy   Assoc. Professor
(tenured-1979)
  1979-1981
 
East Tenn. State University
 J.H. Quillen Coll. of Med.
  Anatomy   Assoc. Professor
(tenured-1983)
  1981-1988
 
East Tenn. State University   Grad. School   Asst. Dean   1986-1989
 
East Tenn. State University   Grad. School   Dean & Acting
Assoc.V. President
For Research
  1989
 
East Tenn. State University
 J.H. Quillen Coll. of Med.
  Anat.& Cell Biol.   Professor/Assoc.Ch.   1988-present
 
Professional Affiliations

American Association of Anatomists, 1975-2001
American Society for Cell Biology, 1973-2001
Microscopy Society of America (formerly: Electron Microscopy Society of America),
1980-present
Appalachian Regional Electron Microscopy Society, 1981-present
     (Biological Representative 2010-present)
Microcirculatory Society, 1992-2001
Alpha Omega Alpha, national medical honor society - 1996-present
 
Teaching Experience
Courses Taught Institution   Dates
General Bacteriology Lab. Penn. State Univ.   1963-1965
(undergraduates) Dept. Microbiology
 
General Bacteriology & University of Colorado   1965-1966
Pathogenic Bacteriology Department of Biology
(undergraduates, nurses)
 
Human Histology - Cell Biology Yale University   1971-1974
(medical and grad. students) School Medicine
 
Ultrastruct. & Function of Louisiana State Univ.   1976
the Plasma Membrane Medical Center
(course director, graduate
students)
 
Cell Biology Louisiana State Univ.   1974-1981
(graduate students) Medical Center
 
Human Histology Louisiana State Univ.   1974-1981
(medical, dental and Medical Center
graduate students)
 
Biological Ultrastructure East Tenn. State Univ.   1983-present
(course director, graduate J. H. Quillen Coll. Med.
students)
 
Human Histology East Tenn. State Univ.   1981-1991
(Course Director, medical J.H. Quillen Coll. Med.
& graduate students)
 
Cell & Tissue Biology East Tenn. State Univ.   1992-present
(Course Director, medical J.H. Quillen Coll. Med.
& graduate students 1992-2009)
 
Anatomy (Physical Therapy East Tenn. State Univ.   1997-2009
students) J. H. Quillen Coll. Med.
 
Other Teaching Experience:

  1. Texas A & M University, Dept. of Anatomy; visiting lecturer in medical histology, Sept.-Nov., 1981 and Sept.-Nov., 1982.
  2. Invited lecturer in Histology, Tennessee Preprofessional Program, Memphis, Tennessee, 1989.
  3. “Basic Human Histology”, University of Salzburg, Salzburg, Austria, September, 2001.
Teaching Awards

  1. "Professor of the Year" awards: 1981, 1986, 1991, 1993, 1995, 2005, 2006 (presented by Freshman Classes, J.H. Quillen College of Medicine)
  2. "Faculty Honor Roll": 1982, 1983, 1984, 1985 (presented by Freshman Classes, J.H. Quillen College of Medicine)
  3. Selected for "Hooding Ceremony", Honors Convocation, 1986, 1988, 2005, 2009, 2010 by Graduating Classes, J.H. Quillen-Dishner College of Medicine)
  4. "Best Faculty" award, Honors Convocation, May 6, 1994 (presented by Graduating Class of 1994)
  5. Election to Alpha Omega Alpha, national medical honor society, April, 1996.
  6. College of Medicine “Dean's Distinguished Teaching Award In The Basic Sciences", 1998.
  7. Gender Equity Award: 1998, 2001, 2007, 2010, 2011.
  8. Cell & Tissue Biology (Course Director) voted best freshman medical course, 2002 & 2005.
  9. Lee Brashier’s Award for “Faculty Whose Dedication to Students Goes Beyond the Classroom”, 1997-1998, 2003-2004, & 2004-2005.
Graduate Student Training
Doctoral Theses Directed:

  1. Michael P. Sarras, Jr., Ph.D., August, 1978 (Louisiana State University) "Ultrastructural and biochemical events associated with plasma membrane biogenesis and turnover in the duckling salt gland"
  2. Judy A.C. King, Ph.D., May 1987 (East Tennessee State University) "Adaptation of striped bass to seawater following direct transfer from fresh water: morphological, biochemical and physiological parameters"
  3. Beatrice Owens, Ph.D., December 2004 (East Tennessee State University) “Effect of estrogen on osteoporosis in rat femurs” (co-chair)
Administrative Experience
    1.  Course director:
         A.  Medical Histology, J.H. Quillen College of Medicine, 1981-1991.
         B.  Biological Ultrastructure, J. H. Quillen College of Medicine, 1983-present.
         C.  Cell & Tissue Biology, J.H. Quillen College of Medicine, 1992-2009     
     2.  Associate Chairman, Department of Anatomy & Cell Biology, 1985-2009
     3.  Assistant Dean, School of Graduate Studies, East Tennessee State University, 1986-1989.
     4.  Acting Associate Vice President for Research and Dean of Graduate School, East Tennessee State University, 1989.
     5.  Director, EM Core Facility, College of Medicine, 2004-2008
Service\Committee Work

  1. J.H. Quillen College of Medicine Research Forum, Organizing Committee: 1985, 1986, 1987, 1990; judge: 1985, 1992.
  2. Admissions Committee, Quillen-Dishner College of Medicine: 1985, 1986, 1987; screener/reviewer: 1985, 1986, 1987.
  3. Faculty Advisory Council, Quillen-Dishner College of Medicine: 1981, 1982, 1983, 1984, 1985, 1986.
  4. Promotion and Tenure Committee, J.H. Quillen College of Medicine, 1989-1992; 2001-2004.
  5. Faculty Senator, East Tennessee State University, 1993-1995.
  6. Core Facility Planning and Vertical Curriculum Review Committees, J. H. Quillen College of Medicine.
  7. Advisor, fund raiser, and Health Careers Symposium Coordinator for Medical Explorer Post, Boy Scouts of America; J.H. Quillen College of Medicine, 1983-1990.
  8. Long Range planning Committee, Biomedical Science Graduate Program, 1995-present.
  9. Community service: (1) seminars and demonstrations of E.M. laboratory facilities to local schools, clubs and charitable organizations.
  10. Women's and Gender Issues, 1996-2001.
  11. Continuing Medical Education Committee, 1999-present.
  12. Director, EM Core Facility, ETSU Quillen College of Medicine, 2003-present.
Invited Presentations - Scholarly Activities ( Regional, National, & International) - Editorial Experience
  1. Visiting scientist, Mount Desert Island Biological Laboratory, Salsbury Cove, ME, 1979
  2. Invited speaker, Sigma Xi, 1982; "Application of Stereology to Research"; 2000, " Fine Structure of the Honey Bee"
  3. Invited external consultant on proposed masters degree program in biology, University of North Carolina at Wilmington, 1986.
  4. Guest Editor, J. Electron Microscopy Technique, 1991 Topical Issue: "The Fine Structure of Blood Vessels"
  5. Invited Symposium speaker "SCANNING-1991", Atlantic City, N.J., State-of-the-Art Review on "Vascular Corrosion Casting"
  6. Invited dinner speaker: "Honey Bees and Pollination", Appalachian Regional Electron Microscopy Society, Virginia Tech Univ., Fall, 1996.
  7. Invited presenter, "Unusual Features of the Microvasculature of the Urinary Bladder Revealed by Vascular Corrosion Casting", 2nd International Malpighi Symposium, Universita Di Roma, La Sapienza, Rome, Italy, September 14-16, 1995
  8. Invited seminar: "Unusual features of the Microvasculature of the Urinary Bladder as Revealed by Vascular Casting", April, 1997; Texas A. & M. University, Health Science Center, College Station, TX
  9. Invited seminar: " Microvasculature of the Urinary Bladder of the Rabbit"; University of Minnesota
  10. College of Medicine, Department of Cell Biology and Neuroanatomy, Minneapolis, MN, November, 1997.
  11. Key Note speaker: "Vascular Corrosion Casting and its Application in Elucidating Some Unique Features of the Microvasculature of the Rabbit Urinary Bladder", Alabama Imaging and Microscopy Society Meeting, Perdido Beach, AL, February, 1998.
  12. Invited seminar: " The Microvasculature of the Urinary Bladder", University of Vienna, First Department of Anatomy, Vienna, Austria, June, 1998.
  13. Symposium organizer: "Advances in Vascular Corrosion Casting in Research"; annual meetings of Microscopy Society of America - 1998, 1999, 2000, 2002, & 2005
  14. Invited conference speaker (Microvasculature of the Urinary Bladder", and "Quantitative Applications of Vascular Corrosion Casting") and consultant on teaching programs, Institute of Biomedical Sciences, Department of Anatomy, College of Medicine, University of Sao Paulo, Brazil; October 19-26, 1999.
  15. Visiting Professorship - University of Salzburg, Salzburg, Austria. September 1 - October 1, 2001.
  16. Invited Seminar; Anatomisches Institut, Univ. Basel, Switzerland; Sept.14, 2001. “Quantitative applications of vascular corrosion casting”
  17. Editorial Board, Journal of Biotechnic & Histochemistry, 2002-2009
  18. Invited speaker, Microscopy Society of America, San Antonio, TX, 2003. Ask The Experts: Vascular Corrosion Casting, Microscopy & Microanal. 9 (supp. 1), 2003.
  19. Invited speaker, SEEMS EM society meeting, “Microvasculature of the mammalian urinary bladder - a preliminary comparative study with corrosion casts”, March 31, 2006, Gatlinburg, TN.
    20.  Invited speaker:  University of Florida Bee College; March 10-12, 2011; "Ultrastructural Anatomy of the Honey Bee in 3-D"
Research
  1. Current Research Interests:
    1. Three-dimensional microvasculature of various normal and pathologic organs and tissues (e.g. heart, lung, bladder, salt gland, teleost gill) studied with vascular corrosion casting, morphometry and scanning electron microscopy.
    2. Three dimensional microvasculature of the mammalian urinary bladder using vascular corrosion casting and scanning electron microscopy.
    3. Na,K,-ATPase-rich epithelia and their response to osmotic load. Rate of salt water to freshwater adaptation in euryhaline teleosts. Response of microvasculature, Na,K-ATPase, and plasma membrane to osmotic stress in the avian salt gland.
    4. Methods of quantitation of the three-dimensional microvasculature of tissues and organs using vascular corrosion casting, scanning electron microscopy, and confocal microscopy
  2. Research Grants and Other Support:
    1. Louisiana State University Institutional Research Grants: 1975, 1976, 1977, 1978.
    2. National Institutes of Health: RO1, Gm24953, "The site and mechanism of plasma membrane renewal", 1978-1981; P.I.
    3. Research Development Committee grants, East Tennessee State University, 1981, 1984, 1986, 1988, 1992.
    4. Deafness Research Foundation, "On the mechanism of endolymph production in the cochlea histological and ultrastructural localization of the Na,K-ATPase", 1981-1982, P.I.
    5. Successful applicant for Burrough's Wellcome Foundation grant for "Wellcome Lecturer", Dr. Russell Barrnett, Section of Cell Biology, Yale University College of Medicine, 1985-1986.
    6. Southern Medical Association: ''Microvasculature of the mammalian myocardium", 1984; "On the mechanism of endolymph synthesis in the avian cochlea", 1985.
    7. National Institutes of Health, NIDDK: RO1, Dk47563-01, "Mucosal Integrity in Female and Male Rabbit Bladders"; contract P.I. with Frederick Monson, P.I., Univ. of Penna.; 1993-1997.
    8. Contract with Bio-Tree Systems, Inc., 2006. Preparation of organ casts.
Publications - Abstracts Presented (Last five years)

  • Czymmek, K., R.C. Wagner, F.E. Hossler, and R. Kao. Imaging and volumetric quantitation of vascular corrosion casts with laser scanning confocal microscopy. Micros. & Microanal. 6 (2), 562-563; Proceedings Microscopy & Microanalysis 2000, Aug. 13-17, 2000, Philadelphia, PA.
  • Ridner, C.W., R.L. Kao, and F. E. Hossler. Microvasculature of the urinary bladder of the dog studied with light microscopy, electron microscopy and vascular corrosion casts. Microsc. & Microanal. 8 (Suppl. 2), 224-225, 2002; August 6, 2002, Quebec City, Quebec, Canada.
  • Hossler, F. E., C.W. Ridner, and R.L Kao. Microvasculature of the dog urinary bladder revealed with vascular corrosion casting and SEM. Tennessee Academy of Science, Nov. 15, 2002, ETSU, Johnson City, TN.
  • Hossler, F. E. Vascular Corrosion Casting, invited presentation: Ask the Experts Symposium, Microscopy Society of America meeting, San Antonio, TX, August, 2004.
  • Hossler, F.E., R.L. Kao, and F.C. Monson. Microvasculature of the mammalian urinary bladder - a preliminary comparative study using vascular corrosion casting. Microsc. & Microanal. 11 (Suppl. 1), 130, Aug. 3, 2005, Honolulu, HI.
  • Wagner, R.C., K. Czymmek, and F. E. Hossler. Confocal microscopy, modeling and quantitation of corroded and non-corroded casts of microvascular systems. Microsc. & Microanal. 11 (Suppl. 1), 130, Aug. 3, 2005, Honolulu, HI. 
  • Hossler, F., J. Heintz, M. Christensen, J. Weichert, and R. Albrecht.  Contrast agents for CT and MRI of vascular casts.  Microsc. & Microanal. 13 (Suppl. 2), 490CD, Aug. 7, 2007, Ft. Lauderdale, Fl.
  • Hossler, F. E., A.Lametschwandtner, R.L.Kao, , C. Bills, and F. Fensterbusch.  Microvascular architecture of the mouse urinary bladder described with vascular corrosion casting. light microscopy, SEM and TEM.  Microsc & Microanal, July 27, 2009, Richmond, VA.
Publications - Full Papers In Reviewed Journals (Last five years)

  • Wagner, D.L., E.W. Hossler, and F.E. Hossler. The larva and pupa of Bomolocha edictalis. J. of the Lepidopterist’s Society, in press (2006).
  • Wagner, R.C., K. Czymmek, and F. E. Hossler. Confocal microscopy, computer modeling and quantitation of glomerular vascular corrosion casts. Microsc, & Microanal. 12:262-268 (2006).
  • Hossler, F. E., and R. Kao. The microvasculature of the dog urinary bladder studied with vascular corrosion casting. In preparation, 2006.  Wagner, R.C., K. Czymmek, and  F. E. Hossler.  Confocal microscopy, computer modeling and quantitation of glomerular vascular corrosion casts.  Microsc. Microanal. 12:262-268 (2006).
  • Wagner, D.L., E.W. Hossler, and F.E. Hossler.  Not a tiger but a dagger: The larva of Comachara cadburyi and reassignment of the genus to Acronictinae (Lepidoptera; Noctuidae) Ann. Entomol. Soc. Am. 99(4):638-647 (2006).
  • Hossler, F. E., and R.L. Kao.  The microvasculature of the dog urinary bladder studied with vascular corrosion casting.  Microsc. Microanal. 13:220-227 (2007).
  • Wagner, R.C., and F. E. Hossler.  Tomographic modeling of casted blood vascular systems.  In Focus 11:4-21 (2008).
  • Negi, S., A. Halawa, D.S. Chi, C. Miller, F. Hossler, G. Youngberg, D.A. Johnson, and G. Krishnaswamy.  Mast cell regulation of cardiovascular inflammation I: Cognate and non-cognate interactions.  In: Mast Cells and Cardiovascular Disease, ed. Joseph, J., Nova Science Publishers, Hauppauge, NY.  2010.
  • Negi, S., A. Halawa, C. Miller, D.S. Chi, F. Hossler, and G. Krishnaswamy.  Mast cell regulation of cardiovascular inflammation II: Infection and innate immunity.  In: Mast Cells and Cardiovascular Disease, ed. Joseph, J., Nova Science Publishers, Hauppauge, NY.  2010.
  • Wagner, R., D. Van Loo, F. Hossler, K. Czymmek, E. Pauwels, and L. Van Hoorebeke.  High resolution imaging of kidney vascular corrosion casts with nano-CT.  Microsc. Microanal. 17:215-219 (2011).
  • Wagner, D.L., E.W. Hossler, and F.E. Hossler.  The larva and pupa of Bomolocha edictalis.  J. of the Lepidopterist’s Society (in preparation).
  • R. Wagner, S. Modla, F. Hossler, and K. Czymmek.  Three-dimensional analysis and computer modeling of the capillary endothelial vesicular system with electron tomography.  Microcirculation 19:477-484 (2012).