Dr. Mitchell Robinson

Dr. Mitchell Robinson

 

 

 

 

Mitchell Robinson, Ph.D.
Professor, Department of Biomedical Sciences 

Contact Information:

J. H. Quillen College of Medicine, ETSU
Department of Biomedical Sciences
Box 70581
Johnson City TN 37614
Room B038, Building 178, VA Campus
Phone:  Lab-(423) 439-2029 
Office-(423) 439-2028
FAX: (423) 439-2030
Email:  

 

Education:

B.S., 1976, University of North Carolina
Ph.D., 1983, Wake Forest University

Interdisciplinary Association

Associate Dean for Graduate Studies at Quillen College of Medicine


Research Interests:

One of the important functions of membrane lipids is to serve as second messengers, molecules that relay information from hormones and other primary signals and, in turn, activate metabolic processes within the cell. Our laboratory is investigating the structure, metabolism and biological role of these lipids.  Of particular interest is the metabolism of diacylglycerols, molecules that are now thought to play a central role in the regulation of cell growth.  We are currently exploring the pathways for the synthesis of diacylglycerols in cultured cells and their response to stimulation by hormones such as insulin and the interleukins.  Gas-liquid chromatography and high performance liquid chromatography techniques have been developed to quantify the low levels of these molecules in cultured mammalian cells.  Our recent studies have focused on a new class of biologically active lipids, alkylglycerols.  Our laboratory has been the first to identify these compounds as components of mammalian cells.  The level of alkylglycerols appear to be high in cells whose growth is inhibited, indicating that they may play a role in the regulation of cell growth.  We are examining the metabolic processes that lead to the accumulation of these lipid molecules.  Recent studies indicate that alkylglycerols are present at very low levels in cultured tumor cells, which is consistent with a role for these molecules as growth inhibitors.

 

References:


  Warne TR, Buchanan FG, Robinson M. Related Articles
  Growth-dependent accumulation of monoalkylglycerol in Madin-Darby canine kidney cells. Evidence for a role in the regulation of protein kinase C.
J Biol Chem. 1995 May 12;270(19):11147-54.
PMID: 7744745 [PubMed - indexed for MEDLINE]
  Robinson M, Burdine R, Warne TR. Related Articles
  Inhibition of phorbol ester-stimulated arachidonic acid release by alkylglycerols.
Biochim Biophys Acta. 1995 Feb 9;1254(3):361-7.
PMID: 7857977 [PubMed - indexed for MEDLINE]
  Warne TR, Robinson M. Related Articles
  A method for the simultaneous determination of alkylacylglycerol, diacylglycerol, monoalkylglycerol, monoacylglycerol, and cholesterol by high-performance liquid chromatography.
Anal Biochem. 1991 Nov 1;198(2):302-7.
PMID: 1799215 [PubMed - indexed for MEDLINE]
  Robinson M, Chen T, Warne TR. Related Articles
  IL-3-induced generation of alkylacylglycerol and diacylglycerol in an IL-3-dependent cell line.
J Immunol. 1991 Oct 15;147(8):2624-9.
PMID: 1918982 [PubMed - indexed for MEDLINE]
  Robinson M, Warne TR. Related Articles
  Sources of diradylglycerols generated during cell growth and phorbol ester stimulation in Madin-Darby canine kidney cells.
Biochim Biophys Acta. 1991 Aug 20;1085(1):63-70.
PMID: 1892879 [PubMed - indexed for MEDLINE]
  Warne TR, Robinson M. Related Articles
  A method for the quantitative analysis of molecular species of alkylacylglycerol and diacylglycerol.
Lipids. 1990 Nov;25(11):748-52.
PMID: 2280680 [PubMed - indexed for MEDLINE]