Attila Szebeni, Pharm. D.
Department of Biomedical Sciences
Atilla Szebeni, Pharm. D.
Assistant Professor, Department of Biomedical Sciences
James H. Quillen College of Medicine
PO Box 70582
Stanton Gerber Hall (VA 178)
Room B-237, Lab A-204
Johnson City, TN 37604
1975 – Master of Pharmacist, University of Albert Szent-Györgyi Medical University, Faculty of Pharmacy (Szeged, Hungary)
1981 - Pharmacist Doctor degree in Phamacology/Neurochemistry
Dr. Szebeni is research assistant professor of Biomedical Sciences at the Quillen College of Medicine in Johnson City, Tennessee. He received his doctorate at the University of Albert Szent-Györgyi Medical University. Dr. Szebeni is a biochemist and has long-standing interests in the development of a comprehensive understanding of biochemical pathways, protein-protein interactions in HIV-1 viral infection and gene expression alterations in brain disease. His research experience in biochemistry and academic studies in pharmacology provide an excellent background in multiple biological disciplines including pharmacobiochemistry, protein chemistry, enzymology, molecular biology, genetics and neurobiology. Dr. Szebeni has been directly responsible for the development of molecular biological methods to investigate the molecular pathology of psychiatric illness using postmortem brain tissue from human donors. In addition, Dr. Szebeni has a long history of mentoring medical, graduate and undergraduate students.
The main focus of my lab is to study molecular and cellular basis of clinical depression and the molecular mechanisms of antidepressant drugs.
I am a core team member of the Molecular Psychiatry team. Dr. Greg Ordway
Xiang L., Szebeni K., Szebeni A., Klimek V., Stockmeier, C.A., Karolewicz B., Kalbfleisch J. and Ordway, G.A.: Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNAs in depression. Brain Res.1207: 214-224, 2008.
Ordway G.A., Szebeni A., Duffourc M.M., Dessus-Babus S. and Szebeni K.: Gene expression analyses of neurons, astrocytes, and oligodendrocytes isolated by laser capture microdissection from human brain: Detrimental effects of laboratory humidity. J. Neurosci. Res., 87: 2430-2438, 2009.
Brown R.W., Noel D.M., Smith J.J., Smith M.L., Huggins K.N., Szebeni K., Szebeni A., Duffourc M., Chandley M., and Ordway G.A.: Eszopiclone Facilitation of the Antidepressant Efficacy of Fluoxetine Using a Social Defeat Stress Model. Pharmacol., Biochem. and Behav., 99: 648-658, 2011.
Ordway G.A., Szebeni A., Chandley M.J., Stockmeier C.A., Xiang L., Newton S.S., Turecki G., Duffourc M., Zhu M.-Y., Zhu H., and Szebeni K.: Reduced gene expression of bone morphogenetic protein 7 in brain astrocytes in major depression. Int. J. Neuropsychopharmacology, 15: 855-868, 2012.
Chandley M.J., Szebeni K., Szebeni A., Stockmeier C.A., Turecki G., Miguel-Hidalgo J.J., and Ordway G.A.: Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder, J. Psychiatr. Neurosci., 38: 276-284, 2013.
Chandley M. J., Szebeni A., Szebeni K., Crawford J. D., Stockmeier C. A., Turecki G., Kostrzewa R. M. and Ordway G. A.: Elevated Gene Expression of Glutamate Receptors in Noradrenergic Neurons from the Locus Coeruleus in Major Depression. I nt. J. Neuropsychopharm. 2014, (in press).
Szebeni A., Szebeni K., DiPeri T., Chandley M. J., Crawford J. D., Stockmeier C. A., and Ordway G. A.: Telomere Shortening and Compensated Gene Expression of Oxidative Stress Defense Enzymes in White Matter Oligodendrocytes in Major Depression. I nt. J. Neuropsychopharm. Int. 2014, (in press).