Professor Emerita, Department of Biomedical Sciences
Teaching Interests:Bacterial cell structure / function; bacterial virulence, pathogenesis and infectious diseases, especially of facultative and obligate intracellular pathogens; inflammation and mucosal immunity.
Fellow, American Academy of Microbiology - 1980
Fellow, American Assoc. for Advancement of Science - 2003
President, Chlamydia Basic Research Society - 2005-2007
Honorary Doctorate Veterinary Medicine, University of Zurich – 2011
Education and Training:
1963 -- B.S., Medical Technology, University of North Carolina, Chapel Hill, NC
1967 -- M.S., Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC
1971 -- Ph.D., Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC
1971-1973 -- Medical Research Council, Scientific Staff Fellow, National Institute for Medical Research, Mill Hill, London, England
1973 – 2000 --Assistant, Associate Professor, and Professor of Microbiology & Immunology, University of North Carolina School of Medicine at Chapel Hill
1. Wyrick, P.B., J. Choong, C.H. Davis, S.T. Knight, M.O. Royal, A.S. Maslow, and C.R. Bagnell. 1989. Entry of genital C. trachomatis into polarized human epithelial cells. Infect. Immun. 57:2378-2389.
2. Wyrick, P.B., C.H. Davis, S.T. Knight, J. Choong, J.E. Raulston, and N. Schramm. 1993. In vitro human epithelial cell culture system for studying the pathogenesis of Chlamydia trachomatis. Sex. Trans. Dis. 20:248-256.
3. Tam, J.E., C.H. Davis, and P.B. Wyrick. 1994. Expression of recombinant DNA introduced into C. trachomatis by electroporation. Can. J. Microbiol. 40:583-591.
4. Schramm, N., C.R. Bagnell, and P.B. Wyrick. 1996. Vesicles containing C. trachomatis Serovar L2 remain above pH6 within HEC-1B cells. Infect. Immun. 64:1208-1214.
5. Dessus-Babus, S., S.T. Knight, and P.B. Wyrick. 2000. Chlamydial infection of polarized cells induces PMN chemotaxis but the cytokine profile varies between disseminating and non-disseminating strains. Cell. Micro. 2(4):317-327.
6. Davis, C.H., J.E. Raulston, and P.B. Wyrick. 2002. Protein Disulfide Isomerase, a Component of the Estrogen Receptor Complex, Is Associated with Chlamydia trachomatis Serovar E Attached to Human Endometrial Epithelial Cells. Infect. Immun. 70(7):3413-3418.
7. Guseva, N.V., S. Dessus-Babus, C.G. Moore, J.D. Whittimore, and P.B. Wyrick. 2007.Differences in Chlamydia trachomatis seovar E growth rate in polarized endometrial andendocervical epithelial cells grown in three-dimensional culture. Infect. Immun. 75 (2):553-564.
8. Hall, J.V., M. Schell, S. Dessus-Babus, C.G. Moore, J. D. Whittimore, M. Sal, B. D. Dill, and P.B. Wyrick. 2011. The multifaceted role of estrogen in enhancing Chlamydia trachomatis infection in polarized human endometrial epithelial cells. Cell. Micro., 1-17. doi:j.1462-5822.2011.01608.
9. Rank, Roger G., J. Whittimore, A. K. Bowlin, ans P.B. Wyrick. 2011. In vivo ultrastructural analysis of the intimate relationship between polymorphonuclear leukocytes and the chlamydial developmental cycle. Infect. Immun. 79(8):3291-3301. [Hghlight]