Professor Emerita, Department of Biomedical Sciences
Teaching Interests:Bacterial cell structure / function; bacterial virulence, pathogenesis and infectious diseases, especially of facultative and obligate intracellular pathogens; inflammation and mucosal immunity.Research Interests
Chlamydia trachomatis
Pathogenesis |
Fellow, American Academy of Microbiology - 1980 Fellow, American Assoc. for Advancement of Science - 2003 President, Chlamydia Basic Research Society - 2005-2007 Honorary Doctorate Veterinary Medicine, University of Zurich – 2011 |
Contact Information:
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Lab Location:
Mailing Address
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Education and Training:
1963 -- B.S., Medical Technology, University of North Carolina, Chapel Hill, NC
1967 -- M.S., Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC
1971 -- Ph.D., Bacteriology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC
1971-1973 -- Medical Research Council, Scientific Staff Fellow, National Institute for Medical Research, Mill Hill, London, England
Professional Background:
1973 – 2000 --Assistant, Associate Professor, and Professor of Microbiology & Immunology, University of North Carolina School of Medicine at Chapel Hill
Research Support:
30 years of NIH R01 funding
Selected Publications:
1. Wyrick, P.B., J. Choong, C.H. Davis, S.T. Knight, M.O. Royal, A.S. Maslow, and C.R. Bagnell. 1989. Entry of genital C. trachomatis into polarized human epithelial cells. Infect. Immun. 57:2378-2389.
2. Wyrick, P.B., C.H. Davis, S.T. Knight, J. Choong, J.E. Raulston, and N. Schramm. 1993. In vitro human epithelial cell culture system for studying the pathogenesis of Chlamydia trachomatis. Sex. Trans. Dis. 20:248-256.
3. Tam, J.E., C.H. Davis, and P.B. Wyrick. 1994. Expression of recombinant DNA introduced into C. trachomatis by electroporation. Can. J. Microbiol. 40:583-591.
4. Schramm, N., C.R. Bagnell, and P.B. Wyrick. 1996. Vesicles containing C. trachomatis Serovar L2 remain above pH6 within HEC-1B cells. Infect. Immun. 64:1208-1214.
5. Dessus-Babus, S., S.T. Knight, and P.B. Wyrick. 2000. Chlamydial infection of polarized cells induces PMN chemotaxis but the cytokine profile varies between disseminating and non-disseminating strains. Cell. Micro. 2(4):317-327.
6. Davis, C.H., J.E. Raulston, and P.B. Wyrick. 2002. Protein Disulfide Isomerase, a Component of the Estrogen Receptor Complex, Is Associated with Chlamydia trachomatis Serovar E Attached to Human Endometrial Epithelial Cells. Infect. Immun. 70(7):3413-3418.
7. Guseva, N.V., S. Dessus-Babus, C.G. Moore, J.D. Whittimore, and P.B. Wyrick. 2007.Differences in Chlamydia trachomatis seovar E growth rate in polarized endometrial andendocervical epithelial cells grown in three-dimensional culture. Infect. Immun. 75 (2):553-564.
8. Hall, J.V., M. Schell, S. Dessus-Babus, C.G. Moore, J. D. Whittimore, M. Sal, B. D. Dill, and P.B. Wyrick. 2011. The multifaceted role of estrogen in enhancing Chlamydia trachomatis infection in polarized human endometrial epithelial cells. Cell. Micro., 1-17. doi:j.1462-5822.2011.01608.
9. Rank, Roger G., J. Whittimore, A. K. Bowlin, ans P.B. Wyrick. 2011. In vivo ultrastructural analysis of the intimate relationship between polymorphonuclear leukocytes and the chlamydial developmental cycle. Infect. Immun. 79(8):3291-3301. [Hghlight]