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Matt P. Keasey
Research Assistant Professor
Dr. Matt P. Keasey
Research Assistant Professor
James H. Quillen College of Medicine
Department of Biomedical Sciences
East Tennessee State University
Johnson City, TN 37614
Stanton Gerber Bldg 178, B214 (office), B216 (Lab)
Office Phone: 423-439-8499
2010 Ph.D., University of Bristol, UK
2005 M.Sc., University of Bristol, UK
1. Neuroprotection and neurogenesis
2. Calcificiation of soft tissues and the role of vitamin D
3. Integrin and molecular signaling pathways
My work has primarily focused on Focal Adhesion Kinase, a major tyrosine kinase involved in integrin signaling, and its role in regulating a number of key cytokines in the brain. Dysregulation and altered signaling after or during neurodegenerative conditions might make this molecule an important pherapeutic target.
I have also taken a keen interest in the role of Vitamin D (Calcitriol) in the
process of calcification of soft tissues, such as the brain.
Role of PDGFRβ extracellular matrix mediated brain calcification, CNPQ Universal Grant # 454077/2014-9
Banerjee K, Keasey MP, Razskazovskiy V, Visavadiya NP, Jia C, Hagg T (2017). Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells. Cellular Signaling. 2017 Aug;36:154-162.
Paiva D, Keasey MP, Oliveira JRM (2017). Mir-9-5p down regulates Pit-2 but not Pit-1 in Human Embryonic Kidney 293 cells. Mar 16. Journal of Molecular Neuroscience, May;62(1):34
Visavadiya NP*, Keasey MP*, Banerjee K, Jia C, Lovins C, Wright GL, Hagg T (2016). Integrin-FAK signaling rapidly
and potently promotes mitochondrial function through STAT3. Cell Communication and
Signaling, Cell Communication and Signaling. Dec 15;14(1):32.
Keasey, M.P., Lemos, R.R., Hagg, T., Oliveira, J.R.M., 2016. Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1. Sci. Rep. 6, 25802.
Keasey, M.P., Scott, H.L., Bantounas, I., Uney, J.B., Kelly, S., 2016. MiR-132 Is Upregulated by Ischemic Preconditioning of Cultured Hippocampal Neurons and Protects them from Subsequent OGD Toxicity. Journal of Molecular Neuroscience 1–7.
Keasey MP, Oliveira JRM (2014). Letter to the editor on Demoulin JB, Essaghir A. PDGF receptor signaling networks in normal and cancer cells. Cytokine & Growth Factor Reviews. Cytokine Growth Facto Rev. 25, 245.
Bezerra BM, Keasey MP, Schiel N, da Silva Souto A (2014). Responses towards a dying adult group member in a wild New World monkey. Primates. 55, 185–188.
Lemos RR1, Ferreira JB, Keasey MP, Oliveira JR (2013). An update on primary familial brain calcification. Int Rev Neurobiol. 110:349-71
Keasey MP, Kang, SS, Lovins, C, Hagg T (2013). Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Communication and Signaling 11(1):35.
Kang SS, Keasey MP, Hagg T (2013). P2X7 receptor inhibition increases CNTF expression in the subventricular zone, but not neurogenesis of neuroprotection after stroke in adult mice. Translational Stroke Research. 4(5):533-45.
Kang SS, Keasey MP, Arnold SA, Reid R, Geralds JT, Hagg T (2013). Endogenous CNTF mediates stroke-induced adult CNS neurogenesis in mice. Neurobiology of Disease. 49: 68-78.