Charles A. Stuart, M.D.
Dr. Stuart is primarily interested in risk factors for obesity and type 2 diabetes. The central mechanism of these two interrelated conditions is hereditary insulin resistance. Dr. Stuart's laboratory in Endocrinology is focused on aberrations of insulin action on glucose uptake into skeletal muscle. The laboratory team has demonstrated that the expression of at least two glucose transporter genes is abnormal in the muscle of subjects with insulin resistance. The mechanism of these abnormalities is currently being pursued by evaluating the structure and function of the human GLUT3 promoter, developing a GLUT3 knockout mouse line, and seeking out quantification of gene expression in muscle of the several novel glucose transporters discovered since 2000.
Stuart continues to be involved in research into effective primary prevention of childhood obesity in Native American communities. Much of the interest in childhood obesity in many collaborating tribes has focused on the use of the skin lesion acanthosis nigricans as an easily recognized external manifestation of hyperinsulinemia. Early work in this project has been the major impetus for State-mandated large-scale school-based screening for obesity and acanthosis nigricans in Texas.