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Department of Internal Medicine Research

Development of Antibiotic Resistance and Epidemiology of Bacterial Pathogens

Titles of Research Projects & Objectives:

Trends in Resistance to a Topical Antimicrobial Agent

Phenotypic and Genotypic Characterization of Mupirocin Heteroresistance in Staphylococcus aureus

'Co-pathogenicity' of Moraxella catarrhalis/S. pneumoniae with Respect to Penicillin Resistance

Efficacy of Mupirocin in Eradication of Nasal Methicillin Resistant Staphylococcus aureus

Genotypic Characterization of Beta-Lactamase Gene in Moraxella catarrhalis with Unusual Penicillin Resistance

Laboratory: This infectious disease laboratory conducts research focusing on the nosocomial pathogens and alterations in antibiotic resistance over time. Long-term collections of pathogens recovered from James H. Quillen VA Medical Center provide the foundation for our genetic and epidemiological analyses of bacterial pathogens.

Faculty: F. A. Sarubbi, M.D. , Chief of Infectious Disease; Foster Levy, Ph.D., visiting faculty, Dept. of Biol. Sci., ETSU; Elaine S. Walker, Ph.D. , VA and Clinical Assistant Professor, Internal Medicine
Staff: Janna Icenhour, M. T. (VA Infection Control)

Molecular biology: Analysis of genetic variation within bacterial species: genomic DNA purification, PCR, pulsed-field gel electrophoresis (PFGE), Southern blot
Aerobic bacteriology - species identification, antibiotic resistance determination by MIC and Kirby-Bauer disk assays

Past funding awarded to:
Investigators: ETSU RDC grant and Grant-in Aid, NIH-AREA, SmithKline, BSRG-NIH, SmithKline Beecham (Glaxo SmithKline), Pfizer
Students: Howard Hughes and Honors Program student research grant

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