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Research/Scholarly Activities | Infectious, Inflammatory and Immunologic Diseases

Division StatementFaculty | Research/Scholarly Activities |  Fellowship |  Quillen ETSU Physicians 

Scholarship in the Division of Infectious, Inflammatory and Immunologic Diseases

The Infectious Diseases division is active in multiple aspects of clinical and basic science research and is highly productive in this area. Division members have received continuous NIH funding for over a decade and our viral pathogenesis laboratories provide a training ground for Infectious Diseases fellows and postdoctoral, graduate, and undergraduate students. Research interests within the division include:

  • immunopathogenesis of HCV and HIV/HCV coinfection with a focus on the innate immune response (Moorman, Yao, Li)
  • basic immunologic mechanisms underlying EBV latency and EBV/HIV co-infection leading to tumorigenesis (Ning)
  • immune response and latency during HIV infection (Li, Yao)
  • translational studies of sepsis in relation to innate immunity (Moorman)
  • neuroimmunologic studies of chronic stress and opioids (Yin)
  • the role of vitamin D in infectious processes (Youssef)

In addition, division members are involved in areas of scholarship that include quality improvement, patient outcomes research, and dissemination of clinical findings. Division members comprise the key editors and authors of the most recent edition of Gantz’s Manual of Clinical Problems in Infectious Diseases, a compendium of Infectious Diseases clinical knowledge.

Recent publications include:

Atia A, Murthy R, Bailey B, Manning T, Garrett L, Youssef D, Peiris AN. Vitamin D status in veterans with inflammatory bowel disease: relationship to healthcare costs and services.Mil Med 2011; 176(6):711-4.

Cheng J. Ma, Jia M. Wang, Ruo S. Ying, Lei Shi, Xiao Y. Wu, Toshiro Niki, Mitsumi Hirashima, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao*. 2013. Cis association of Galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling. PLoS One (Epub Ahead of Print)

Dziuba N, Ferguson MR, O'Brien WA, Sanchez A, Prussia AJ, McDonald NJ, Friedrich BM, Guangyu Li, Shaw MW, Sheng J, Hodge TW, Rubin DH, Murray JL. 2012. Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1. AIDS Res Hum Retroviruses.

El Abbassi A, Shams W, Moorman J, Elshenawy Y, Youssef D. Pulmonary infection with caseating mediastinal lymphadenitis caused by Mycobacterium gordonae. Chest 2012 Oct; 142(4 meeting abstracts):185A.

Friedrich BM, Dziuba N, Guangyu Li, Endsley MA, Murray JL, Ferguson MR. 2011. Host factors mediating HIV-1 replication. Virus Res. 2011 Nov;161(2):101-114.

Friedrich BM, Murray JL, Guangyu Li, Sheng J, Hodge TW, Rubin DH, O'Brien WA, Ferguson MR. 2011. A functional role for ADAM10 in human immunodeficiency virus type-1 replication. Retrovirology. 2011 May 11;8:32.

George J, Khazrik H, Youssef D, Peiris AN. Vitamin D deficiency: awaiting final proof? Tenn Med 2013; 106(2):43.

Griffin J, Moulton M, Elmeyazen R, Moorman J. Negative Immunomodulators: Blunting Immunostimulation and Facilitating Infection. Immunstimulation (in press).

Guangyu Li, Brian Friedrich, Natallia Dziuba, James L. Murray, Monique R. Ferguson. 2011. A post-entry role for CD63 in early HIV-1 replication. Virology. 412:315-324.

Guangyu Li, Friedrich B, Dziuba N, Ferguson MR. 2010. Quantitative PCR used to assess HIV-1 integration and 2-LTR circle formation in human macrophages, peripheral blood lymphocytes and a CD4+ cell line. Virol J. 3;7:354.

Ilyas S, Youssef D, Chaudhary H, Al-Abbadi MA. Mycobacterium-avium intracellulare associated inflammatory pseudotumor of the anterior nasal cavity. Head Neck Pathol 2011 Sep; 5:296-301.

Ji, X.J., C.J. Ma, J.M. Wang, X.Y. Wu, T. Niki, M. Hirashima, J.P. Moorman, and Z.Q. Yao. 2012. Hepatitis C Virus Induces CD4+CD25+Foxp3+ Regulatory T cell Development through the Tim-3/Gal-9 Pathway. Eur. J Immunol. [Epub ahead of print]

Jia M. Wang, Yong Q Cheng, Lei Shi, Ruo S. Ying, Xiao Y. Wu, Hanspeter Pircher, Guang Y. Li, Jonathan P. Moorman, Zhi Q. Yao. 2013. KLRG1 negatively regulates natural killer (NK) cell functions through Akt pathway in individuals with chronic hepatitis C. J Virol. (Epub Ahead of Print)

Lei Ni, Cheng J. Ma, Ying Zhang, Subhadra Nandakumar, Chun L. Zhang, Xiao Y. Wu, Thomas Borthwick, Uday Kumaraguru, Jonathan P. Moorman, and Zhi Q. Yao. 2011. PD-1 modulates Regulatory T cells and suppresses T cell responses in HCV-associated Lymphoma. Immunology & Cell Biology 89:535-539.

Ma C, Lei N, Zhang Y, Wu X, Atia A, Thayer P, Moorman JP, Yao Z.Q. 2011. PD-1 negatively regulates IL-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C
infection. Immunology 132:421-31.

Moorman, J.P., C.L. Zhang, L. Ni, C.J. Ma, Y. Zhang, X.Y. Wu, P.Thayer, T.Borthwick, and Z.Q. Yao. 2011. Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4+ T cell responses. Vaccine 29:3169-76.

Moorman, J.P., J.M.Wang, Y.Zhang, X.J.Ji, C.J.Ma, X.Y.Wu, Z.S.Jia, K.S.Wang, and Z.Q.Yao. 2012. Tim-3 controls regulatory and effector T cell balance during HCV Infection. J. Immunol. 189:755-66.
Peiris AN, Youssef D, Grant WB. Secondary hyperparathyroidism: benign bystander or culpable contributor to adverse health outcomes? South Med J 2012;105(1):36-42.

Peiris AN, Youssef D, Jones K. The non-compliant patient. Tenn Med 2012 Aug; 105(7):56-7.

Peiris AN, Youssef D. The computerized patient and the art of bedside diagnosis. South Med J 2011; 104(9):623.

Peiris AN, Youssef D. The traditional medical history: a casualty of the check list? South Med J 2011; 104(11):717.

Wang JM, Ma CJ, Li GY, Wu XY, Thayer P, Greer P, Smith AM, High KP, Moorman JP, Yao ZQ. 2013. Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection. Vaccine 31:2238-45.

Wang JM., L. Shi, CJ. Ma, XJ. Ji, RS. Ying, XY. Wu, KS. Wang, GY. Li, JP Moorman, ZQ. Yao*. 2013. Differential regulation of IL-12/IL-23 by Tim-3 drives TH17 cell development during HCV infection. J. Virol. 87:4372-83.

Yao, Z.Q*. and J.P.Moorman. 2013. Immune exhaustion and immune senescence – two distinct pathways for HBV vaccine failure during HCV and/or HIV infection (Review). AITE 61:193-201.

Youssef D, Bailey B, Atia A, El Abbassi A, Manning T, Peiris AN. Differences in outcomes between cholecalciferol and ergocalciferol supplementation in veterans with inflammatory bowel disease. Geriatr Gerontol Int 2012. July; 12(3):475-80.

Youssef D, Bailey B, El Abbassi A, Manning T, Vannoy M, Moorman JP, Peiris AN. Healthcare costs of methicillin resistant Staphylococcus aureus and Pseudomonas aeruginos infections in veterans: role of vitamin D deficiency. Eur J Clin Microbiol Infect Dis 2012; 1(3):281-6.

Youssef D, El Abbassi A, Cutchins D, Chhabra S, Peiris AN. Vitamin D deficiency: implications for acute care in elderly and patients with chronic illness. Geriatr Gerontol Int 2011 Oct; 11(4):395-407.

Youssef D, Grant WB, Peiris AN. Vitamin D deficiency: a potential risk factor for Clostridium difficile infection.Risk Manag Health Policy 2012; 5:115-6. Epub 2012 Oct 8.

Youssef D, Miller C, El Abbassi A, Cutchins D, Cutchins C, Grant WB, Peiris AN. Antimicrobial implications of vitamin D. Dermatoendocrinology 2011 Oct; 3(4):220-9. Epub 2011 Oct 1.

Youssef D, Raval B, El Abbassi A, Patel P. Pulmonary blastomycosis during pregnancy: case report and review of the literature. Tenn Med 2013; 106(3):37-9.

Youssef D, Shams W, Abu Malouh AK, Al-Abbadi MA. Chronic organizing retroperitoneal abscess caused by Klebsiella Oxytoca masquerading as sarcoma: recognition by Diff-Quik stain on FNA material. Diagn Cytopathol 2011 Aug; 40(8):747-50.

Youssef D, Shams W, Bailey B, O’Neil TJ, Al-Abbadi MA. Effective strategy for decreasing the rate of blood cultures contamination: the experience of a Veterans Affairs Medical Center. J Hosp Infect 2012 Aug; 81(4):288-91.

Youssef D, Shams W, El Abbassi A, Moorman JP, Al-Abbadi M. Combining cytomorphology and serology for the diagnosis of cat scratch disease. Diagn Cytopathol 2011; 39(3):210-3.

Youssef D, Shams W, Ganote CE, Al-Abbadi MA. The negative image of blastomyces on Diff-Quick stain. Acta Cytologica 2011; 55(4):377-381.

Youssef DA, Bailey B, Manning T, Peiris AN. Is vitamin D superior to albumin in predicting length of stay and mortality in veterans of long-term care facilities? Tenn Med 2013 (in press)

Youssef DA, Peiris AN, Kelley JL, Grant WB. The possible roles of vitamin D and curcumin n treating gonorrhea. Medical Hypotheses 2013; 81(1), July:131-135.

Youssef DA, Ranasinghe T, Grant WB, Peiris AN. Vitamin D’s potential to reduce the risk of hospital-acquired infections. Dermatoendocrinology 2012 Apr 1; 4(2):167-75.

Zhang Y., C.J. Ma, J.M. Wang, X.J. Ji, X.Y. Wu, J P. Moorman, and Z.Q. Yao. 2011. Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ Monocytes. 2012 . Journal of Leukocyte Biology (Leading Edge Research Article) 91; 189-196. See accompanying editorial, Journal of Leukocyte Biology.

Zhang Y., C.J.Ma, X.Y.Wu, J.P.Moorman, and Z.Q.Yao. 2011. A Crucial Role for Tim-3 in Negative Regulation of Monocyte IL-12 Production in Chronic Hepatitis C Infection. PLoS One 6:e19664.

Zhang,Y., C.J.Ma, L.Ni, X.Y.Wu, U.S.Kumaraguru, C.F. Li, J.P.Moorman, and Z.Q.Yao. 2011. Crosstalk between PD-1 and SOCS-1 in HCV core-mediated IL-12 suppression. Journal of Immunology 186:3093-103.

Zhi Q. Yao, Lei Ni, Ying Zhang, Cheng J. Ma, Chun L. Zhang, Zhi P. Dong, Ashley D. Frazier, Xiao Y. Wu, Penny Thayer, Thomas Borthwick, Xin Y. Chen, and Jonathan P. Moorman. 2011. Differential Regulation of T and B lymphocytes by PD-1 and SOCS-1 signaling in Hepatitis C Virus-associated non-Hodgkin’s Lymphoma. Immunol Invest. 40:243-64.

Zhou Y., Y.Zhang, Z.Q.Yao, J.P.Moorman, Z.S.Jia. 2012. Dendritic cell-based immunity and vaccination against hepatitis C virus infection. Immunology 136:385-96.



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