Research/Scholarly Activities | Infectious, Inflammatory and Immunologic Diseases

Division StatementFaculty | Research/Scholarly Activities |  Fellowship |  Quillen ETSU Physicians 

Scholarships in the Division of Infectious, Inflammatory and Immunologic Diseases

The Infectious Diseases division is active in multiple aspects of clinical and basic science research and is highly productive in this area. Division members have received continuous NIH funding for over a decade and laboratories provide a training ground for Infectious Diseases fellows and postdoctoral, graduate, and undergraduate students. Research interests within the division include:

●immunopathogenesis of hepatitis C infection
●epidemiologic studies in HIV infection
●vaccine trials in HIV infection
●molecular studies of HIV pathogenesis
●investigator-initiated clinical trials of antimicrobials

In addition, division members are involved in areas of scholarship that include quality improvement, patient outcomes research, and dissemination of clinical findings. Division members comprise the key editors and authors of the most recent edition of Gantz’s Manual of Clinical Problems in Infectious Diseases, a compendium of Infectious Diseases clinical knowledge.

Recent publications include:

Lei Ni, Cheng J. Ma, Ying Zhang, Subhadra Nandakumar, Chun L. Zhang, Xiao Y. Wu, Thomas Borthwick, Uday Kumaraguru, Jonathan P. Moorman, and Zhi Q. Yao. 2011. PD-1 modulates Regulatory T cells and suppresses T cell responses in HCV-associated Lymphoma. Immunology & Cell Biology 89:535-539.

Zhi Q. Yao, Lei Ni, Ying Zhang, Cheng J. Ma, Chun L. Zhang, Zhi P. Dong, Ashley D. Frazier, Xiao Y. Wu, Penny Thayer, Thomas Borthwick, Xin Y. Chen, and Jonathan P. Moorman. 2011. Differential Regulation of T and B lymphocytes by PD-1 and SOCS-1 signaling in Hepatitis C Virus-associated non-Hodgkin’s Lymphoma. Immunol Invest. 40:243-64.

Guangyu Li, Brian Friedrich, Natallia Dziuba, James L. Murray, Monique R. Ferguson. 2011. A post-entry role for CD63 in early HIV-1 replication. Virology. 412:315-324.

Friedrich BM, Murray JL, Guangyu Li, Sheng J, Hodge TW, Rubin DH, O'Brien WA, Ferguson MR. 2011. A functional role for ADAM10 in human immunodeficiency virus type-1 replication. Retrovirology. 2011 May 11;8:32.

Dziuba N, Ferguson MR, O'Brien WA, Sanchez A, Prussia AJ, McDonald NJ, Friedrich BM, Guangyu Li, Shaw MW, Sheng J, Hodge TW, Rubin DH, Murray JL. 2012. Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1. AIDS Res Hum Retroviruses.

Friedrich BM, Dziuba N, Guangyu Li, Endsley MA, Murray JL, Ferguson MR. 2011. Host factors mediating HIV-1 replication. Virus Res. 2011 Nov;161(2):101-114.

Guangyu Li, Friedrich B, Dziuba N, Ferguson MR. 2010. Quantitative PCR used to assess HIV-1 integration and 2-LTR circle formation in human macrophages, peripheral blood lymphocytes and a CD4+ cell line. Virol J. 3;7:354.

Ma C, Lei N, Zhang Y, Wu X, Atia A, Thayer P, Moorman JP, Yao Z.Q. 2011. PD-1 negatively regulates IL-12 expression by limiting STAT-1 phosphorylation in monocytes/macrophages during chronic hepatitis C
infection. Immunology 132:421-31.

Zhang,Y., C.J.Ma, L.Ni, X.Y.Wu, U.S.Kumaraguru, C.F. Li, J.P.Moorman, and Z.Q.Yao. 2011. Crosstalk between PD-1 and SOCS-1 in HCV core-mediated IL-12 suppression. Journal of Immunology 186:3093-103.

Moorman, J.P., C.L. Zhang, L. Ni, C.J. Ma, Y. Zhang, X.Y. Wu, P.Thayer, T.Borthwick, and Z.Q. Yao. 2011. Impaired hepatitis B vaccine responses during chronic hepatitis C infection: involvement of the PD-1 pathway in regulating CD4+ T cell responses. Vaccine 29:3169-76.

Zhang Y., C.J.Ma, X.Y.Wu, J.P.Moorman, and Z.Q.Yao. 2011. A Crucial Role for Tim-3 in Negative Regulation of Monocyte IL-12 Production in Chronic Hepatitis C Infection. PLoS One 6:e19664.

Zhang Y., C.J. Ma, J.M. Wang, X.J. Ji, X.Y. Wu, J P. Moorman, and Z.Q. Yao. 2011. Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ Monocytes. 2012 . Journal of Leukocyte Biology (Leading Edge Research Article) 91; 189-196. See accompanying editorial, Journal of Leukocyte Biology.

Moorman, J.P., J.M.Wang, Y.Zhang, X.J.Ji, C.J.Ma, X.Y.Wu, Z.S.Jia, K.S.Wang, and Z.Q.Yao. 2012. Tim-3 controls regulatory and effector T cell balance during HCV Infection. J. Immunol. 189:755-66.

Zhou Y., Y.Zhang, Z.Q.Yao, J.P.Moorman, Z.S.Jia. 2012. Dendritic cell-based immunity and vaccination against hepatitis C virus infection. Immunology 136:385-96.

Wang JM., L. Shi, CJ. Ma, XJ. Ji, RS. Ying, XY. Wu, KS. Wang, GY. Li, JP Moorman, ZQ. Yao*. 2013. Differential regulation of IL-12/IL-23 by Tim-3 drives TH17 cell development during HCV infection. J. Virol. 87:4372-83.

Yao, Z.Q*. and J.P.Moorman. 2013. Immune exhaustion and immune senescence – two distinct pathways for HBV vaccine failure during HCV and/or HIV infection (Review). AITE 61:193-201.

Wang JM, Ma CJ, Li GY, Wu XY, Thayer P, Greer P, Smith AM, High KP, Moorman JP, Yao ZQ. 2013. Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection. Vaccine 31:2238-45.

Ji, X.J., C.J. Ma, J.M. Wang, X.Y. Wu, T. Niki, M. Hirashima, J.P. Moorman, and Z.Q. Yao. 2012. Hepatitis C Virus Induces CD4+CD25+Foxp3+ Regulatory T cell Development through the Tim-3/Gal-9 Pathway. Eur. J Immunol. [Epub ahead of print]

Jia M. Wang, Yong Q Cheng, Lei Shi, Ruo S. Ying, Xiao Y. Wu, Hanspeter Pircher, Guang Y. Li, Jonathan P. Moorman, Zhi Q. Yao. 2013. KLRG1 negatively regulates natural killer (NK) cell functions through Akt pathway in individuals with chronic hepatitis C. J Virol. (Epub Ahead of Print)

Cheng J. Ma, Jia M. Wang, Ruo S. Ying, Lei Shi, Xiao Y. Wu, Toshiro Niki, Mitsumi Hirashima, Chuan F. Li, Jonathan P. Moorman, Zhi Q. Yao*. 2013. Cis association of Galectin-9 with Tim-3 differentially regulates IL-12/IL-23 expressions in monocytes via TLR signaling. PLoS One (Epub Ahead of Print)

Griffin J, Moulton M, Elmeyazen R, Moorman J. Negative Immunomodulators: Blunting Immunostimulation and Facilitating Infection. Immunstimulation (in press).

Combining cytomorphology and serology for the diagnosis of cat scratch disease. Youssef D, Shams W, El Abbassi A, Moorman JP, Al-Abbadi M. Diagn Cytopathol 2011; 39(3):210-3.

The negative image of blastomyces on Diff-Quick stain. Youssef D, Shams W, Ganote CE, Al-Abbadi MA. Acta Cytologica 2011; 55(4):377-381.

Vitamin D status in veterans with inflammatory bowel disease: relationship to healthcare costs and services. Atia A, Murthy R, Bailey B, Manning T, Garrett L, Youssef D, Peiris AN. Mil Med 2011; 176(6):711-4.

Chronic organizing retroperitoneal abscess caused by Klebsiella Oxytoca masquerading as sarcoma: recognition by Diff-Quik stain on FNA material. Youssef D, Shams W, Abu Malouh AK, Al-Abbadi MA. Diagn Cytopathol 2011 Aug; 40(8):747-50.

The computerized patient and the art of bedside diagnosis. Peiris AN, Youssef D. South Med J 2011; 104(9):623.

Mycobacterium-avium intracellulare associated inflammatory pseudotumor of the anterior nasal cavity. Ilyas S, Youssef D, Chaudhary H, Al-Abbadi MA. Head Neck Pathol 2011 Sep; 5:296-301.

Vitamin D deficiency: implications for acute care in elderly and patients with chronic illness. Youssef D, El Abbassi A, Cutchins D, Chhabra S, Peiris AN. Geriatr Gerontol Int 2011 Oct; 11(4):395-407.

Antimicrobial implications of vitamin D. Youssef D, Miller C, El Abbassi A, Cutchins D, Cutchins C, Grant WB, Peiris AN. Dermatoendocrinology 2011 Oct; 3(4):220-9. Epub 2011 Oct 1.

The traditional medical history: a casualty of the check list? Peiris AN, Youssef D. South Med J 2011; 104(11):717.

Secondary hyperparathyroidism: benign bystander or culpable contributor to adverse health outcomes? Peiris AN, Youssef D, Grant WB. South Med J 2012;105(1):36-42.

Healthcare costs of methicillin resistant Staphylococcus aureus and Pseudomonas aeruginos infections in veterans: role of vitamin D deficiency. Youssef D, Bailey B, El Abbassi A, Manning T, Vannoy M, Moorman JP, Peiris AN. Eur J Clin Microbiol Infect Dis 2012; 1(3):281-6.

Differences in outcomes between cholecalciferol and ergocalciferol supplementation in veterans with inflammatory bowel disease. Youssef D, Bailey B, Atia A, El Abbassi A, Manning T, Peiris AN. Geriatr Gerontol Int 2012. July; 12(3):475-80.

The non-compliant patient. Peiris AN, Youssef D, Jones K. Tenn Med 2012 Aug; 105(7):56-7.

Vitamin D deficiency: a potential risk factor for Clostridium difficile infection. Youssef D, Grant WB, Peiris AN. Risk Manag Health Policy 2012; 5:115-6. Epub 2012 Oct 8.

Vitamin D’s potential to reduce the risk of hospital-acquired infections. Youssef DA, Ranasinghe T, Grant WB, Peiris AN. Dermatoendocrinology 2012 Apr 1; 4(2):167-75.

Effective strategy for decreasing the rate of blood cultures contamination: the experience of a Veterans Affairs Medical Center. Youssef D, Shams W, Bailey B, O’Neil TJ, Al-Abbadi MA. J Hosp Infect 2012 Aug; 81(4):288-91.

Pulmonary infection with caseating mediastinal lymphadenitis caused by Mycobacterium gordonae. El Abbassi A, Shams W, Moorman J, Elshenawy Y, Youssef D. Chest 2012 Oct; 142(4 meeting abstracts):185A.

Vitamin D deficiency: awaiting final proof? George J, Khazrik H, Youssef D, Peiris AN. Tenn Med 2013; 106(2):43.

Pulmonary blastomycosis during pregnancy: case report and review of the literature. Youssef D, Raval B, El Abbassi A, Patel P. Tenn Med 2013; 106(3):37-9.

Is vitamin D superior to albumin in predicting length of stay and mortality in veterans of long-term care facilities? Youssef DA, Bailey B, Manning T, Peiris AN. Tenn Med 2013 (in press)

The possible roles of vitamin D and curcumin n treating gonorrhea. Youssef DA, Peiris AN, Kelley JL, Grant WB. Medical Hypotheses 2013; 81(1), July:131-135.

The research programs in the Division of Infectious Diseases encompass a broad spectrum which includes:

-Studies on antibiotic resistance

-Clinical Drug Trials

-Hepatitis C