Michael T. Gallagher, Ph.D.CURRICULUM VITAE
Home Address: 1707 Colonial Ridge Road
Johnson City, TN 37604
(423) 929-0762
Business Address:
East Tennessee State University
Department of Health Sciences
P.O. Box 70,673
Johnson City, Tennessee 37614-0763
(423) 439-7664, gallaghe@etsu.edu
Education:
1966 - B.S., University of Houston, Houston,
Texas.
1970 - M.S., Northwestern University, Evanston,
Illinois.
1974 - Ph.D., Baylor College of Medicine, Houston,
Texas.
Research and Professional Experience
1989 - Present Professor and Chair, Department of Health Sciences, East Tennessee State University, Adjunct Professor, Department of Microbiology, James H. Quillen College of Medicine, Johnson City, Tennessee, and Director, East Tennessee State University Honors Program (1992-98).
1985-89 Associate Professor, Department of Pediatrics,
Microbiology/
Immunology, Southern Illinois University School
of Medicine, Springfield, Illinois and Director of Flow Cytometry, St.
John's Hospital, Springfield, Illinois.
1982-85 Associate Research Scientist, Department
of Clinical and Experimental Immunology, Division of Medicine, City
of Hope National Medical Center, Duarte, California.
1981-82 Assistant Research Scientist, Department of Clinical and Experimental Immunology, Division of Medicine, City of Hope National Medical Center, Duarte, California.
1980-81 Assistant Research Scientist, Division of Clinical Pathology, City of Hope National Medical Center, Duarte, California.
1979-80 Adjunct Assistant Professor, Program in Immunology, University of Texas Graduate School of Biomedical Sciences, Houston,Texas.
1975-80 Assistant Professor, Division of Experimental Biology, Baylor College of Medicine, Houston, Texas.
1974-75 Instructor, Division of Experimental Biology, Baylor College of Medicine, Houston, Texas.
1970-74 Research Assistant, Division of Experimental Biology, Baylor College of Medicine, Houston, Texas.
1969-74 Predoctoral Fellow, Division of Experimental Biology, Baylor College of Medicine, Houston, Texas.
1967-69 Graduate Student, Northwestern University,
Evanston, Illinois.
Research Interests
Immunotoxicology, transplantation immunology,
cancer immunology, bone marrow transplantation, graft-versus-host
disease, differentiation of blood cells, and macrophage function.
Memberships and Societies ( past and present )
American Society
for Microbiology
American Association
for the Advancement of Science
American Association
of Immunologists
International
Society for Experimental Hematology
American Association
For Cancer Research
The Tennessee
Academy of Science
Federation of
American Societies for Experimental Biology (FASEB)
Sigma Xi
Phi Kappa Phi
Awards
1967-69 USPHS Traineeship,
Northwestern University.
1969-74 National Cancer
Institute Traineeship, Baylor College of Medicine.
1976
Travel Fellowship to Congress of Immunology in Sydney from The American
Association of Immunologists.
1990
Sigma Xi
1992
Phi Kappa Phi
Teaching Experience
1970-80 - Baylor College of Medicine. Participation
in Division of Experimental Biology courses in Tissue Transplantation,
Cancer Immunology
and Immunohematology offered by the Graduate
School at Baylor College of Medicine. Lecturer on bone marrow
transplantation, graft-versus-host disease, genetic resistance to
bone marrow transplantation, T and B cells, and experimental anemias.
Director of Special Methods course involving laboratory methods used in experimental bone marrow transplantation and studies of hemopoietic differentiation.
Participation in inter-institutional courses Immunology
I, II, and
III offered by the Graduate School of Baylor
College of Medicine and the University of Texas Graduate School of
Biomedical Sciences. Lecturer
on bone marrow transplantation, natural
resistance to leukemia-lymphoma, natural killer cells and nude and
asplenic mice as models of human immunodeficiency diseases.
Chairman of two graduate students' advisory committees.
1) Florence Harrod Gardner was awarded the Ph.D. from Baylor College
of Medicine in 1979; thesis topic "The side effects of murine thymus-derived
cell cultures, both normal and transformed, upon the in vitro and
in vivo cell mediated responses of syngeneic lymphoid cells."
2) Jan David Galla was
awarded the M.D. and Ph.D. from Baylor
College of Medicine in 1981; thesis topic "Studies on early hemopoietic
stem cell populations."
1985-1989 - SIU School of Medicine. Participation
in Immunology course for 2nd year medical students. Lecturing
on various topics including, cells of the immune system, complement,
transplantation immunology, bone marrow transplantation, immunophenotyping
of tumors,
aids, and regulations of the immune system.
Director of immunology lectures for pediatric
residents.
1987-1989 - SIU Graduate School.
Co-Director of advanced immunology course; Chairman of one graduate
student's Advisory Committee and member of two other student Advisory Committees.
Participation in Immunology Laboratory Methods course.
1989-present - East Tennessee State University.
Undergraduate courses taught - Introduction to Microbiology,
Introduction to Microbiology Lab, General Microbiology, General Microbiology
Lab, Mycology, Immunology, Environmental Microbiology and Great Ideas in
Science. Graduate courses taught - Immunology, Immunology lab methods
and various special topics courses; Graduate Students - Chairman
of 4 graduate student committees (1 PhD and 3 MS ), member of 14 other
graduate student advisory committees (1 at the PhD level).
Selected Committees and University Service
1974 Member, Symposium Organizing Committee - III Annual Symposium of the International Society for Experimental Hematology, Houston, Texas.
1978-80 Member, Curriculum and Policy Committee, School of Graduate Studies, Baylor College of Medicine.
1978 Member, Ad Hoc Committee for the Future of Graduate Studies at Baylor College of Medicine.
1978-80 Elected member of the Nominating Committee of the International Society for Experimental Hematology.
1981-85 Institutional Review Board, City of Hope National Medical Center (Human Research Subjects Review).
1984-85 President, Research Staff Organization, City of Hope National Medical Center and Beckman Research Institute.
1985-86 Past President, Research Staff Organization, City of Hope National Medical Center and Beckman Research Institute.
1984-85 Member, Faculty Senate, City of Hope National Medical Center.
1984-85 Research Staff Organization Executive Committee, City of Hope National Medical Center.
1984-85 Associate Member, Board of Directors, Beckman Research Institute of the City of Hope National Medical Center.
1984-85 Member, Beckman Endowment Fund Advisory Committee, City of Hope National Medical Center.
1984 Member, Symposium Organizing Committee - Neuroimmunology: Exploring parallels and interaction between the immune and nervous systems - 10/07/84.
1987-89 Member Springfield, Illinois Committee for Research Involving Human Subjects.
1989-94 Member, General Education Core Revision Committee, East Tennessee State University.
1989-Present Member, Dean's Council, College of Public and Allied Health
1990-92 Member, Research Development Committee (Chair 1990-91), East Tennessee State University.
1990-93 Member, Presidential Grant-In-Aid Committee, East Tennessee State University.
1991 Member, Search Committee, Vice President for Research and Dean of the Graduate School, East Tennessee State University.
1991-94 Member, Faculty Senate, East Tennessee State University.
1991-94 Member, Institutional Review Board, East Tennessee State University.
1991-93 Member, SACS Institutional Effectiveness Committee, East Tennessee State University.
1991-92 Member, Executive Committee, Southern Appalachian Chapter Sigma Xi.
1993 Member, Search Committee, Vice President for Academic Affairs, East Tennessee State University
1994 Member, Search Committee, Dean of the College of Nursing, East Tennessee State University.
1994-Present Member, General Education Advisory Committee, East Tennessee State University.
1996-97 Member, General Education Review Steering Committee
1995-Present Member, General Education Assessment Committee
1998 Member, Search Committee Vice President for Student Affairs
1998
Member, Search Committee ETSU Honors Director
Publications ( excluding published abatracts )
1. Trentin, J. J., McGarry, M. P., Jenkins, V. K., Gallagher, M. T., Speirs, R. S. and Wolf, N. S.: Role of inductive micro- environments on hemopoietic (and lymphoid?) differentiation, and role of thymic cells in the eosinophilic granulocyte response to antigen. IN Morphological and Functional Aspects of Immunity, Plenum Publishing Company, New York, 1971. pp. 289-298.
2. Stockman, G. D., Gallagher, M. T., Heim, L. R., South, M. A. and Trentin, J. J.: Differential stimulation of mouse lymphoid cells by phytohemagglutinin and pokeweed mitogen. Proc. Sco. Exp. Biol. Med. 136:980-982, 1972.
3. Richie, E. R., Gallagher, M. T. Heim, L. R., South, M. A. and Trentin, J. J.: Inhibition of the mixed lymphocyte reaction with Fab fragments from antihuman ALG. Proc. Soc. Exp. Biol. Med. 140:916-919, 1972.
4. Gallagher, M. T., Richie, E. R., Heim, L. R., Judd, K. P. and Trentin, J. J.: Inhibition of the graft-versus-host reaction. I. Reduction of the graft-versus-host potential of mouse spleen cells (with a sparing of stem cells) by pretreatment with antilymphocyte globulin-derived Fab fragments. Transplantation 14:597-602, 1972.
5. Rauchwerger, J. M., Gallagher, M. T., and Trentin, J.J.: "Xenogeneic resistance" to rat bone marrow transplantation. II. Relationship of hemopoietic regeneration and survival. Biomedicine 18:109-111, 1973
6. Trentin, J. J., Rauchwerger, J. M. and Gallagher, M.T.: Genetic resistance to marrow transplantation. Biomedicine 18:86-88, 1973.
7. Richie, E.R., Gallagher, M.T. and Trentin, J.J.: Prevention of graft-versus-host disease by Fab fragments derived from ALG. Transpl. Proc. 5:873-876, 1973.
8. Gallagher, M.T., Richie, E.R. and Trentin, J.J.: Inhibition of allograft reactivity in vitro and in vivo by Fab fragments obtained from ALG. Transpl. Proc. 5:869-872, 1973.
9. Rauchwerger, J.M., Gallagher, M.T. and Trentin, J.J.: "Xenogeneic resistance" to rat bone marrow transplantation. I. The basic phenomenon. Proc. Soc. Exp. Biol. Med 143:145-146, 1973.
10. Richie, E.R., Gallagher, M.T. and Trentin, J.J.: Inhibition of the graft-versus-host reaction. II. Prevention of acute graft-versus- host mortality by Fab fragments of antilymphocyte globulin. Transplantation 15:486-491, 1973.
11. Rauchwerger, J.M., Gallagher, M.T. and Trentin, J.J.: Role of the hemopoietic inductive microenvironments (HIM) in xenogeneic bone marrow transplantation. Transplantation 15:610-613, 1973.
12. Gallagher, M.T., Rauchwerger, J.M., McCredie, K.B. and Trentin, J.J.: The in vitro colony forming potential of in vivo erythroid and granuloid spleen colonies. Exp. Hematol. 1:64-65, 1973.
13. Speirs, R., Gallagher, M.T., Rauchwerger,
J.M. Heim, L. and Trentin, J.J.: Lymphoid cell dependence of eosinophil
response to antigen. II. Location of memory cells and their dependence
upon thymic influence. Ex. Hematol. 1:150-158, 1973.
14. Trentin, J.J., Rauchwerger, J.M. and Gallagher, M.T.: Regulation of hemopoietic stem cell differentiation and proliferation by hemopoietic inductive microenvironments (HIM). IN Control of Proliferation in Animal Cells (B. Clarkson and R. Baserga, eds.), Cold Springs Harbor Laboratory, 1974.
15. Gallagher, M.T.: Studies in Immunohematology. Doctoral thesis, Baylor College of Medicine, 1974.
16. Lotzova, E., Gallagher, M.T. and Trentin, J.J.: Involvement of macrophages in genetic resistance to bone marrow grafts. Studies with two specific anti-macrophage agents, carrageenan and silica. Biomedicine 22:387-392, 1975.
17. Lotzova, E., Gallagher, M.T. and Trentin, J.J.: Genetic control of resistance to rat bone marrow grafts in mice. Biomed. Express 23:335- 336, 1975.
18. Rauchwerger, J.M., Gallagher, M.T., Monie, H.J. and Trentin, J.J.: "Xenogeneic resistance" to rat bone marrow transplantation, III. Maturation age and abrogation with cyclophosphamide, corynebacterium parvum and fractionated irradiation. Biomedicine 24:20-25, 1976.
19. Gallagher, M.T., Lotzova, E. and Trentin, J.J.: Genetic resistance to bone marrow transplantation as a leukemia defense mechanism. Biomedicine 25:1-3, 1976.
20. Trentin, J.J, Gallagher, M.T. and Lotzova, E.: Xenogeneic and genetic resistance to bone marrow transplantation: Relationship to leukemia surveillance. Transpl. Proc. 8:463-468, 1976.
21. Lotzova, E., Gallagher, M.T. and Trentin, J.J.: Macrophage involvement in genetic resistance to bone marrow transplantation. Transpl. Proc. 8:477-482, 1976.
22. Gallagher, M.T., Lotzova, E. and Trentin, J.J.: Genetic resistance to marrow transplantation as a leukemia defense mechanism. IN The ImmunoAspects of the Spleen (J.R. Battisto and J. W. Streilein, eds.), North Holland Publishing Co., 1976 pp. 359-371.
23. Rauchwerger, J.M., Gallagher, M.T., Monie, H.J. and Trentin, J.J.: Relative radioresistance of xenogeneic and hybrid resistance to bone marrow transplantation. Transplantation 23:158-160, 1977.
24. Trentin, J.J., Gallagher, M.T. and Priest, E.L.: Failure of functional transfer of maternal lymphocytes to F1 hybrid mice. Transpl. Proc. 9:1473-1475, 1977.
25. Gallagher, M.T., Harrod, F., Kulkarni, S.S and Trentin, J.J: Effect on GVH disease of in vitro donor cells pretreatment with rabbit antisera against various mouse lymphoid tissues. Transpl. Proc. 9:1045, 1977.
26. Trentin, J.J., Kiessling, R., Wigzell, H., Gallagher, M.T., Datta, S.K. and Kularni, S.S.: Bone marrow transplantation immunology. IN Experimental Hematology Today (S.J. Baum and G.D. Ledney, eds.), Springer-Verlag, New York, 1977. pp. 179-183.
27. Lotzova, E., Dicke, K.A., Trentin, J.J. and Gallagher, M.T.: Genetic control of bone marrow transplantation in irradiated mice. Classification of mouse strains according to their responsiveness to bone marrow allografts and xenografts. Transpl. Proc. 9:289, 1977.
28. Datta, S.K., Gallagher, M.T. and Trentin, J.J.: Natural Killer (NK) cell mediated cytotoxicity versus lymphoma in hamsters. IN Progress in Experimental Tumor Research 23 (J. Trentin and F. Homburger, eds.), S. Karger AG Publishers, Basel, 1978. pp.
29. Datta, S.K., Gallagher, M.T. and Trentin, J.J.: Natural Cell-mediated cytotoxicity in hamsters. In. J. Canc. 23:738-734, 1979.
30. Kulkarni, S.S., Kulkarni, A.D., Gallagher, M.T. and Trentin, J.J.: Prolongation of cardiac allograft survival by pretreatment of recipient mice with donor blood or spleen cells and cyclophosphamide. Cell. Immunol. 47:192-196, 1979.
31. Datta, S.K., Gallagher, M.T., Trentin, J.J.,
Kiessling, R. and Wigzell, H.: Apparent identity of mechanisms of
genetic resistance to marrow transplantation and natural killer cell activity.
Biomedicine 31:62-661979.
32. Gallagher, M.T., Datta, S.K. and Trentin, J.J.: Genetic resistance
to bone marrow transplantation as a leukemia-lymphoma defense mechanism:
Correlation of in vivo lymphoma resistance and in vitro NK activity.
Biomed. Express 33:73, 1980.
33. Kanamaru, A., Durban, E., Gallagher, M.T., Miller, S.C. and Trentin, J.J.: Augmentation of erythroid burst formation by the addition of thymocytes and other myelo-lymphoid cells. J. Cell. Physiol. 104:187, 1980.
34. Gardner, F.H., Gallagher, M.T., Datta, S.K. and Trentin, J.J.: The abrogation of in vivo resistance to parental bone marrow transplantation and in vitro natural cell-mediated cytotoxicity to the YAC lymphoma by in vivo growth of a transformed thymus-derived cell culture. Exp. Hematol. :1040-1047, 1980.
35. Nasrallah, A.G., Gallagher, M.T., Priest, E.L. and Trentin, J.J.: Comparative effects of different strains of C. parvum on natural cell mediated cytotoxicity. Canc. Res. 40:4159-4164, 1980.
36. Kulkarni, S.S., Kulkarni, A.D., Gallagher, M.T. and Trentin, J.J.: Amelioration of graft-versus-host disease by pretreatment of allogeneic cells with Fab fragments. Transplantation 31:72, 1981.
37. Gallagher, M.T., Nasrallah, A.G., Datta, S.K., Priest, E.L. and Trentin, J.J.: Augmentation of natural killer cell activity in spleens of infant, aged, and low responder strain mice by Corynebacterium parvum. Exp. Hematol. 9:149-155, 1981.
38. Miller, S.C., Gallagher, M.T., Datta, S.K. and Trentin, J.J.: Development of natural killer cell activity and genetic resistance to bone marrow transplantation with age. Effect of neonatal thymectomy. Scand. J. Immunol. 13:105-110, 1981.
39. Nasrallah, A.G., Gallagher, M.T., Priest, E.L. and Trentin, J.J.: Lack of suppressor cell activity for natural killer cells in infant, aged, and low responder strain mice. Biomedicine 34:180-183, 1981.
40. Conley, C.L., Lippman, S.M., Ness, P.M.,
Petz, L.D., Branch, D.R. and Gallagher, M.T.: Autoimmune hemolytic
anemia with reticulocytopenia and erythroid marrow. N. Engl.
J. Med. 306:281-286,1982
41. Forman, S., Nocker, P., Gallagher, M.T.,
Zaia, J., Wright, C., Bolen, J., Mills, B. and Blume, K.G.: Pattern
of T cell reconstitution following allogenic bone marrow transplantation
for acute hematologic malignancy. Transplantation 34:96-98, 1982.
42. Branch, D.R., Gallagher, M.T., Forman, S.J., Winkler, K.J., Petz, L.D. and Blume, K.G.: Endogenous stem cell repopulation resulting in mixed hematopoietic chimerism following total body irradiation and marrow transplantation for acute leukemia. Transplantation 34:226-228, 1982.
43. Trentin, J.J., Datta, S.K., Priest, E.L., Gallagher, M.T. and Nasrallah, A.G.: Adoptive transfer of both high NK activity and resistance to development of lymphoma-leukemia, from C57XAKR to AKR mice. Experimental Hematology 10:Supplement 12, 6-11, 1982.
44. Nasrallah, A.G., Gallagher, M.T., Datta, S.K., Priest, E.L. and Trentin, J.J.: Lack of suppressor cell activity for natural killer cells in infant, aged and a low responder strain of mice. IN NK Cells and Other Natural Effector Cells (R.B. Herberman, ed). Academic Press, New York, pp. 557-561, 1982.
45. Trentin, J.J., Datta, S.K., Priest, E.L., Gallagher, M.T. and Nasrallah, A.G.: Transfer of NK activity and lymphoma resistance to AKR mice by marrow from high NK, lymphoma-resistant (C57 x AKR) F1 mice. IN NK Cells and Other Natural Effector Cells (R.B. Herberman, ed). Academic Press, New York pp. 1405-1409, 1982.
46. Gallagher, M.T., Branch, D.R., Mision, A. and Petz, L.D.: Evaluation of reticuloendothelial function in autoimmune hemolytic anemia using an in vitro assay of monocyte-macrophage interaction with erythrocytes. Experimental Hematology 11:82-87, 1983.
47. Gallagher, M.T.: Natural killer cells: A first line of defense against tumors. City of Hope Quarterly 12:6-8, 1983.
48. Alperin, J.B., Riglin, H., Branch, D.R., Gallagher, M.T. and Petz, L.D.: Anti-M causing delayed hemolytic transfusion reaction. Transfusion 23:322-324, 1983.
49. Gallagher, M.T.: Experimental basis, IN Clinical Bone Marrow Transplantation (L.D. Petz and K.G. Blume, eds), Churchill Livingstone, New York, pp. 33-64, 1983.
50. Forman, S.J., and Gallagher, M.T.: Immune reconstitution. IN Clinical Bone Marrow Transplantation (L.D. Petz and K.G. Blume, eds.), Churchill Livingstone, New York, pp. 65-90, 1983.
51. Branch, D.R., Gallagher, M.T., Shulman, I.A.,
Mison, A., Sy Siok Hian, A.L. and Petz, L.D.: Reticuloendothelial
cell function in alpha-methyldopa induced hemolytic anemia. Vox Sanguinis
45:278-287, 1983.
52. Branch, D.R., Gallagher, M.T., Mison, A.P., Sy Siok Hian, A.L. and
Petz, L.D.: In vitro determination of red cell alloantibody
significance using an assay of monocyte-macrophage interaction with
sensitized erythrocytes. British Journal of Hematology 56:19-29,
1984.
53. Forman, S.J., Gallagher, M.T., Zaia, J.A. Wright, C. and Blume, K.G.: Cyclosporin does not prevent in vivo expression of T-cell activation antigens following allogeneic bone marrow transplantation. Transplantation 37:218-219, 1984.
54. Zaia, J.A., Forman, S.J., Gallagher, M.T., Vanderwal-Urbina, E., Blume, K.G.: Prolonged human cytomegalovirus viremia following bone marrow transplantation. Transplantation 37:315-317, 1984.
55. Petz, L.D., Branch, D.R., Stock, A.D., de Lange, G., Rahbar, S., Gallagher, M.T., Yam, P., Wallace, R.B. and Blume, K.G.: Endogenous stem cell repopulation after high dose pretransplant radiochemotherapy. Transpl. Proc. 17:432-433, 1985.
56. Branch, D. R., Berkowitz, L.R., Becker, R.L. Robinson, J., Martin, M., Gallagher, M.T. and Petz, L.D.: Extravascular hemolysis following the administration cefamandole. Am. J. Hematol. 18:213-219, 1985.
57. Branch, D.R. and Gallagher, M.T.: Red blood cell mononuclear phagocyte assay (letter). Vox Sang 48:323-324, 1985.
58. Forman, S.J., Zaia, J.A., Clark, B.R.., Wright, C.L., Gallagher, M.T., Mills, B.J., Racklin, B.C. and Blume K.G.: In vitro cellular immune response to the lake 64K glycoprotein of cytomegalovirus; evidence for T-cell activation. Transpl. Proc. 17:507-509, 1985.
59. Forman, S.J., Zaia, J.A., Clark, B.R. Wright, C.L., Mills, B.J., Pottathil, R., Racklin, B.C., Gallagher, M.T., Welte, K. and Blume, K.G.: A 64,000 dalton matrix protein of human cytomegalovirus induces in vitro immune responses similar to those of whole viral antigen. J. Immunol. 134:3391-3395, 1985.
60. Branch, D.R. and Gallagher, M.T.: The importance of CO2 in short-term monocyte-macrophage assays (Letter). Transfusion 15:399, 1985.
61. Forman, S.J., Zaia, J.A., Wright, C.L., Gallagher, M.T. and Blume, K.G.: Increased LEU-7-positive T lymphocytes during cytomegalovirus infection following allogeneic bone marrow transplantation for hematologic malignancies. Transplantation 41:268-271, 1986.
62. Branch, D.R. and Gallagher, M.T.: Correlation of in vivo alloantibody significance or insignificance with an in vitro monocyte-macrophage assay system. British Journal of Hematology 62:783-86, 1986.
63. Landsperger, W., Gallagher, M.T. and Branch, D.R., Biological activity of intravenous immunoglobulin. Lancet May 2:1035, 1987.
64. Akber, J., Gallagher, M.T., Matthew, L., Ayoub, D., and Miale, T.D.: Severely destructive skeletal lesions as the first manifestation of acute childhood leukemia. American Journal of Pediatric Hematology/Oncology 10:258-261, 1988.
65. Choudhury, C., Raman, C., Gallagher, M.T., and Tewari, R.: Restoration of natural killer cell activity and immuno-competence against Histoplasma capsulatum in hairy cell leukemia following treatment with recombinant alpha interferon. Current Therapeutic Research 45:179-187,1989
66. Davis, D. and Gallagher, M.T.: The effects
of propanil and carbaryl on Fc receptor mediated phagocytosis by human
monocyte-macrophages (Submitted 1999).