HSCI 3540
IMMUNOLOGY ( 3 credits )
Immunology is taught each Spring
on Tuesday and Thursday from 2:15 to 3:35 and Thursday from 3:45 to 5:05.
Second sessions on Thursday are devoted to the oral communication compoments
of the course. Immunology is a requirement for the B.S. in Health Sciences
for both the Microbiology
and Medical Technology concentrations.
The course is also accepted as an elective in the B.S. in Biological Sciences
Biochemistry concentration. Students should complete 2 semesters of General
Biology, 2 semesters of General Chemistry, General Microbiology and at
least one semester of Organic Chemistry proir to enrolling in HSCI 3540.
Lecture
Topics
Day /Topic
1/Introduction
2 /Overview of Immunology
3 /Innate and Acquired Immunity
4 /Innate and Acquired Immunity
(cont.)
5 /Antigens
6 /Antibody Structure
7 /Properties of Antibodies
8 /Genetics of Antibody Formation
9 /Genetics of Antibody Formation
(cont.)
10 /Antigen-Antibody Interactions
11 /Antigen-Antibody Interactions
(cont.)
12 /Exam 1
13 /Complement
14 /Ontogeny of Immune Cells
15 /Ontogeny of Immune Cells
(cont.)
16 /The Immune Response
17 /The Immune Response and
MHC
18 /MHC
19 /Spring Break
20 /Spring Break
21 /Disorders of the Immune
System
22 /Disorders of the Immune
System (cont.)
23 /Hypersensitivity Type
I and II
24 /Hypersensitivity Type
III and IV
25 /Exam 2
26 /Control of the Immune
Response
27 /Control of the Immune
Response (cont.)
28 /Autoimmunity
29 /Transplantation
30 /Tumor Immunology
31 /Vaccines and Immunotherapy
32 /Immunotherapy .
Text
and Instructor.
TEXT : IMMUNOLOGY A SHORT COURSE
by Benjamini and Leskowitz
INSTRUCTOR - Michael
T. Gallagher Ph.D. 249 Lamb Hall (423) 439-7664, gallaghe@etsu.edu
Oral
communication components
Immunology has a significant oral
communication component. Each student is required to present a 15-20 minute
talk on a topic in modern immunology and to participate in four group problem
solving sessions during the semester. These oral communication components
make —up 25% of the course grade.
Sample
Exam
Immunology Exam 1 Sample
1.) Define the following
terms. ( 3pts each )
a.) Interferons
b.) Antigen
c.) Idiotype
d.) Recombinases
e.) Antibody Affinity
f.) Epitope
g.) Fab Fragment
h.) Rag 1
i.) Plasma Cell
j.) Fc Receptor
k.) IgG
l.) Kupffer Cell
m.) Bursa of Fabricius
n.) Class Switching
o.) CD4
2.) Draw and label an immunoglobulin
Molecule. Please be complete. (5pts)
3.)Compare and contrast
the following pairs. ( 5 pts each )
a.) The Innate and The
Acquired Immune System
b.) Primary and Secondary
Immune Responses
c.) Allotype and Isotype
d.) Macrophages and Neutrophils
4.)The Clonal Selection
Theory is central to the understanding of modern immunology. Describe this
theory and indicate how it can explain specificity of the
immune response and immunologic memory. ( 10 pts )
5.) Tell me what the complement
system is and discuss its three major functions. Please be complete.
(10 pts )
6.) Immunoglobulin gene
rearrangement is the major mechanism which contributes to the generation
of antibody diversity. Plese describe how this mechanism works using the
immunogobulin Heavy chain as an example. In addition name two other
mechanisns which can contribute to antibody diversity. (10pts )
Grading
There are two in-class
exams each term (see lecture topics.) Each of the in-class exams counts
as100 points. There is a take-home final, stressing critical thinking and
problem solving, which counts as 100 points. The oral components of the
course count as100 points (the oral presentation counts 60 points and the
four group problem solving sections count 10 points each.) Total points
earned is divided by four and the following grading scale is applied:
A = 93 to 100
A- = 90 to 92.99
B+ = 87 to 89.99
B = 83 to 86.99
B- = 80 to 82.99
C+ = 77 to 79.99
C = 73 to 76.99
C- = 70 to 72.99
D = 60 to 69.99
F = Below 60
Health Sciences
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