David S. Roane, Ph.D. is Professor and
Chair of the Department of Pharmaceutical Sciences at East Tennessee
State University College of Pharmacy.
Dr. Roane received his Ph.D. in Physiology
from the LSU Health Sciences Center in New Orleans in 1987, where he
worked with Dr. Johnny R. Porter studying the dysfunction of endogenous
opioid systems in a genetic model of obesity. Dr. Roane’s postdoctoral
fellowship was performed with Dr. Roy J. Martin in the Department of
Nutrition at the University of Georgia, in a study on the role of diet
in the alteration of nociception.
Dr. Roane joined the Pharmacology faculty in
the School of Pharmacy at the University of Louisiana, Monroe in 1989.
In 2003 he was appointed as the K. Degree Endowed Professor of Biology
and Head of the Department of Biology. Dr. Roane joined the ETSU College
of Pharmacy in 2006.
Dr. Roane teaches portions of Anatomy and
Physiology, and Pharmacology. Dr. Roane is member of the American
Physiological Society, the Society for Neuroscience the Southeast
Pharmacology Society, Phi Kappa Phi, Rho Chi.
Education
|
1982 – 1987 |
Ph.D. in Physiology
LSU Health Sciences Center, New Orleans
|
|
1980 – 1984 |
B.S. in Zoology
Louisiana Tech University
|
|
1975 – 1979 |
B.A. in Journalism
Drake University
|
Professional Experience
|
2006 - Present |
Professor and Chair
Department of Pharmaceutical Sciences
East Tennessee State University
|
|
2003 – 2006 |
Chair and K. DeGree Endowed
Professor of Biology
Department of Biology
University of Louisiana Monroe
|
|
1989-2004 |
Assistant, Associate and Full
Professor of Pharmacology
Department of Basic Sciences
School of Pharmacy
University of Louisiana Monroe
|
| 1987-1989 |
Postdoctoral Research Associate
Department of Nutrition
University of Georgia |
Ancillary appointments
|
2003 –
2007 |
Adjunct Professor
Pennington Biomedical Research Center
Louisiana State University
|
|
2003-2005 |
Adjunct Graduate Faculty
Division of Nutrition
Louisiana State University
|
|
2000-2004 |
Adjunct Graduate Faculty
College of Nursing
University of Mississippi Medical Center |
Research/Scholarship Interests
Dr. Roane research interests center on the
molecular mechanisms of energy metabolism in neurons that affect
neurotransmission and synaptic signaling, particularly as these relate
to obesity and the regulation of glucose homeostasis. His research has
been supported by the NIH and the Diabetes Trust Foundation.
Selected Publication Presentations
Zhang Y, S.S. Yacoub, D.S. Roane. K+ATP
channels allow metabolic regulation of norepinephrine release in the rat
hypothalamus. Exp. Brain Res. In preparation Spring, 2009.
Bayard M. M., R.D. Franks, J.A. Wadzinski,
D.S. Roane. Valproate associated hyperammonemic
encephalopathy. J. Am. Board Fam. Med. 20:499-502,
2007.
Bogacka, I.U., D.S. Roane, X. Xi, J.
Zhou, B. Li, DH. Ryan and RJ. Martin. Expression levels of genes likely
involved in glucose-sensing in the obese Zucker rat brain. Nutr.
Neurosci. 7(2):67-74, 2004.
Zhang, Y., J. Zhou, C. Corrl, J.R. Porter, R.
J. Martin, D.S. Roane. Evidence for hypothalamic K+ATP channels
in the modulation of glucose homeostasis. Eur. J. Pharmacol.,
492(1):71-9, 2004.
Xi, X., D.S. Roane, J. Zhou, D.H. Ryan,
R.J. Martin. Double-color fluorescence in situ hybridization with
RNA probes Biotechniques, 34(5):914-6, 918, 2003.
Li, B., X, Xi, D. S. Roane, D. H. Ryan,
R. J. Martin. Distribution of glucokinase, SUR1, GLP-1 receptor and NPY
messenger RNA’s in rat brain by quantitative real time RT-PCR. Brain
Res. Mol. Brain Res. 113(1-2):139-42, 2003.
Zhou, J. D.S. Roane, X. Xi, I. Bogacka,
B. Li, D.H. Ryan, R.J. Martin. Short term food restriction and
re-feeding alter expression of gene likely involved in brain
glucosensing. Exp. Biol. Med. 228(8):943-50, 2003.
Hill, R.A., S. Rudra, B. Peng, D.S. Roane,
J.K. Bounds, Y. Zhang, A.A. Adloo, T. Lu. Hydroxyl-substituted
sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to
rat brain synaptosomes. Bioorganic Med. Chem. 11/9:2099-2113,
2003.
Zhang, Y. and D.S. Roane,
Glibenclamide’s action in the hypothalamus alters peripheral glucose
homeostasis. Eur. J. Pharmacol. 424(2):R1-R2, 2001.
