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Biomedical Sciences

Quillen College of Medicine

Yong Jiang
Yong Jiang

Yong  Jiang 

Assistant Professor
Biomedical Sciences






Additional Contact Information:

Dr. Yong Jiang
Department of Biomedical Sciences
James H. Quillen College of Medicine
PO Box 70582
Office: Bldg. 178, Room A027
Lab: A030
Phone: 423-439-4918


Curriculum Vitae


Dr. Jiang received his Ph.D. degree from Wayne State University School of Medicine, where he learned and accumulated research experience as a biochemist. His area of expertise ranges from genes expression regulation, protein purification and structure analysis. During his postdoctoral training at Medical University of South Carolina and Cleveland Clinic, he focused on the mechanistic study of TGF-β signaling pathway and Wnt/β-catenin signaling pathway, which are two key pathways for both tumorigenesis and cardiac fibrosis.


Our research has been focusing on the diseases regulated by TGF-b and Wnt signaling pathways.  We try to illustrate the underlying mechanisms by which the diseases are modulated by novel factors in these two pathways. We will determine whether these new factors can be the potential therapeutic targets to cure these diseases.

Jiang figure 1    Jiang figure 2

  1. Discover new therapeutic targets to attenuate metastasis and chemoresistance in cancer.
  1. Discover new therapeutic targets to prevent the development of cardiac fibrosis.

    Teaching Interests:
    Cancer Biology and Cell Biology for both PhD students and Medical Students.


Undergraduate students: Zachary Miller, Lonnie Arnett, Danielle Eaton
Research Associate: Jinyu Zhang, Ph.D., DVM (full-time volunteer).


  1. Jiang Y, Woosley AN, Howe PH. Disabled-2; an autophagic and apoptotic switch. Cell Cycle. 2016 Dec 16;15(24):3319-3320. doi: 10.1080/15384101.2016.1222747. Epub 2016 Aug 25. PubMed PMID: 27559620; PubMed Central PMCID: PMC5224445.
  2. Jiang Y, Woosley AN, Sivalingam N, Natarajan S, Howe PH. Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy. Nat Cell Biol. 2016 Aug;18(8):851-63. doi: 10.1038/ncb3388. Epub 2016 Jul 11. PubMed PMID: 27398911; PubMed Central PMCID: PMC5937135.
  3. Jiang Y, He X, Howe PH. Disabled-2 (Dab2) inhibits Wnt/β-catenin signaling by binding LRP6 and promoting its internalization through clathrin. EMBO J. 2012 May 16;31(10):2336-49. doi: 10.1038/emboj.2012.83. Epub 2012 Apr 10. PubMed PMID: 22491013; PubMed Central PMCID: PMC3364753.
  4. Mayorga ME, Dong F, Sundararaman S, Huang Y, Jiang Y, Howe PH, Penn MS. Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction. Stem Cells Dev. 2011 Apr;20(4):681-93. doi: 10.1089/scd.2010.0151. Epub 2010 Sep 13. PubMed PMID: 20666606.
  5. Jiang Y, Luo W, Howe PH. Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions. Oncogene. 2009 Aug 20;28(33):2999-3007. doi: 10.1038/onc.2009.157. Epub 2009 Jul 6. PubMed PMID: 19581931; PubMed Central PMCID: PMC2804437.
  6. Jiang Y, Prunier C, Howe PH. The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin. Oncogene. 2008 Mar 20;27(13):1865-75. doi: 10.1038/sj.onc.1210829. Epub 2007 Oct 8. PubMed PMID: 17922036; PubMed Central PMCID: PMC2810718.
  7. Polikanov YS, Bondarenko VA, Tchernaenko V, Jiang YI, Lutter LC, Vologodskii A, Studitsky VM. Probability of the site juxtaposition determines the rate of protein-mediated DNA looping. Biophys J. 2007 Oct 15;93(8):2726-31. doi: 10.1529/biophysj.107.111245. Epub 2007 Jun 15. PubMed PMID: 17573434; PubMed Central PMCID: PMC1989718.
  8. Jiang Y, Bhattacharjee H, Zhou T, Rosen BP, Ambudkar SV, Sauna ZE. Nonequivalence of the nucleotide binding domains of the ArsA ATPase. J Biol Chem. 2005 Mar 18;280(11):9921-6. doi: 10.1074/jbc.M413391200. Epub 2005 Jan 6. PubMed PMID: 15637064.
  9. Bondarenko VA, Jiang YI, Studitsky VM. Rationally designed insulator-like elements can block enhancer action in vitro. EMBO J. 2003 Sep 15;22(18):4728-37. doi: 10.1093/emboj/cdg468. PubMed PMID: 12970185; PubMed Central PMCID: PMC212734.
  10. Bondarenko VA, Liu YV, Jiang YI, Studitsky VM. Communication over a large distance: enhancers and insulators. Biochem Cell Biol. 2003 Jun;81(3):241-51. doi: 10.1139/o03-051. Review. PubMed PMID: 12897858.

 Link to Selected Publications



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