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Stanton-Gerber Hall (VA 178)
B.S. 1965 Davidson College
M.S.P.H. 1967 UNC, Chapel Hill
Ph.D. 1971 UNC, Chapel Hill
Research lies in the area of general cardiovascular pathophysiology. Specifically, control of solute and water transport and blood flow in small blood vessels, micro-circulation and vascular cell biology. Cellular basis for mechanistic alteration(s) of the vascular wall in normal, hypertensive, diabetic and alcoholic environments. We are monitoring intracellular signaling pathways in endothelial cells after activation with inflammation agonists. Thus, inflammation, injury, and ischemia are investigated using in vivo and in vitro models.
Xie, Z., Singh, M., Siwik, DA., Joyner, W.L., Singh, K. Osteopontin inhibits interleukin-1?-stimulated
increases in matrix metalloproteinases activity in adult rat cardiac fibroblasts:
role of protein kinase C-zeta. J. Biol. Chem. 2003, 278:48546-48552.
Tang, T. and B.A. Connelly and W.L. Joyner. Heterogenity of endothelial cell function for angiotensin conversion in series-arranged arterioles. Journal of Vascular Research 1995:32:129-137
Kern, D.F., L.I. Holtsclaw and W.L. Joyner. Bradykinin's effect on tracheal microvessel pressure flow and permeability. Am. J. Resp.and Crit. Care Med., 151(4), 1995.
Pass, J.M., B. Connelly, N. Robinson, and W.L. Joyner. Protein kinase C and its regulation in endothelial cells by bradykinin. Microcirculation 4:(1):178, 1997.