Inside Internal Medicine - Volume 4 Article 7
Dr. Tuqa Alkhateeb, PharmD, MS, an Internal Medicine Graduate Student Wins 1st Place in the 2019 Student Research Forums
Dr. Tuqa Alkhateeb, a Biomedical Sciences Ph.D. candidate working in Internal Medicine with the mentorship of Dr. Mohamed Elgazzar, has won first place in the Doctoral Medicine & Disease Oral Presentation at the 2019 Appalachian Student Research Forum. Dr. Alkhateeb discussed the topic: S100A9 Sustains Myeloid-Derived Suppressor Expansion and Immunosuppression During Chronic Murine Sepsis. Her research hopes to find pathways to end sepsis infections and save lives.
Dr. Alkhateeb iterated that s epsis is initiated by a hyperinflammatory reaction, which shifts to an anti-inflammatory/immunosuppressive state. This late response alters innate and adaptive immunity by reprogramming myeloid-derived phagocytes, which enhances immunosuppression, increases opportunistic infections, and elevates mortality and morbidity. Since multiple sepsis interventions aimed at reducing early hyperinflammation have uniformly failed, a promising strategy is to improve sepsis outcomes by reversing chronic immunosuppression. We find that the acute phase S100A9 protein is a regulator of myeloid-derived suppressor cell (MDSC) expansion and concomitant immunosuppression during late/chronic sepsis in mice. Molecular targeting of S100A9 to inhibit MDSC expansion and sepsis-induced chronic immunosuppression might improve sepsis survival.
The department would like to congratulate Tuqa on her achievement.