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Quillen College of Medicine

David L. Williams, PhD - Sepsis, inflammation and innate immunity

Research Team

David L. Williams, PhD
Professor, Department of Surgery
James H. Quillen College of Medicine
East Tennessee State University, Johnson City, TN 37614-0575
(423) 439-6363, fax (423) 439-6259


Research Interests

Recent Publications 

Ma, H., Wang, X., Ha., T., Gao, M., Liu, L., Wang, R., Yu, K., Kalbfleisch, J.H., Kao, R.L. Williams, D.L., Li, C. MicroRNA-125b prevents cardiac dysfunction in polymicrobial sepsis by targeting TRAF6-mediated nuclear factor kB activation and p53-mediated apoptotic signaling. J. Infect. Dis. 214(11):1773-1783, 2016.

Arts, R.J.W., Novakovic,B., ter Horst, R., Carvalho, A., Bekkering, S., Lachmandas, E., Rodrigues, F., Silvestre, R., Cheng, S-C, Wang, S., Habibi, E., Goncalves, L.G., Mesquita, I., Cunha, C., van Laarhoven, A., van der Veerdonk, F.L, Williams, D.L., van der Meer, J. W.M., Logie, C., O’Neill, L.A., Dinarello, C.A., Riksen, N.P., van Crevel, R., Clish, C., Notebaart, R.A., Joosten, L.A.B., Stunnengerg, H.G., Xavier, R.J., Netea, M.G.  Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity.  Cell Metabolism 13;24(6):807-819, 2016.

Garcia-Valtanen P., Guzman-Genuino R.M., Williams D.L., Hayball J.D., Diener K.R. Evaluation of trained immunity by β-1, 3 (D)-glucan on murine monocytes in vitro and duration of response in vivo. Immunol Cell Biol. 95(7):601-610, 2017

Lowman,D.W., Greene,R.R., Bearden,D.W., Kruppa, M.D., Pottier, M., Monteiro,M.A., Soldatov, D.V., Ensley, H.E., Cheng, S.C., Netea, M.G., Williams, D.L. Novel structural features in Candida albicans hyphal glucan provide a basis for differential innate immune recognition of hyphae versus yeast.  J. Biol, Chem. 289(6):3432-43, 2014.

Camilli, G., Eren, E., Williams, D.L., Aimanianda,V., Meunier, E., Quintin, J. Impaired phagocytosis directs human monocyte activation in response to fungal derived b-glucan particles. Eur. J. Immunol. (in press), 2018.

List of Published Work in my Bibliography




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