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College of Public Health

Kesheng Wang

Kesheng Wang

Associate Professor, Department of Biostatistics and Epidemiology
Contact:
423-439-4481 /
Office location: Lamb Hall, room 46C (G-1 level) 
Mailing address: Box 70259, Johnson City, TN 37614

 


EDUCATION

Postdoctoral Fellow, Genetic Epidemiology and Statistical Genetics
The Hospital for Sick Children / University of Toronto, Toronto, Canada, 2002-2006

PhD, Genetics and Biometry (Specializations: Population Genetics and Biometry)
Georg-August-University of Goettingen, Goettingen, Germany

MA, Genetics (Specializations: Biostatistics and Quantitative Genetics)
China Agricultural University, Beijing, China

BS, Biology, Henan Normal University, Xinxiang, China

COURSES TAUGHT

  • Biostatistics I (BSTA 5310)
  • Biostatistics II (BSTA 5350)
  • Categorical Data Analysis (BSTA 5370)
  • Epidemiology II (EPID 5405)
  • Genetic Epidemiology (EPID 5480)
  • SAS Programming with Application in Public Health (BSTA 6170)
  • Advanced Multivariate Analysis (EPID 6410)
  • Molecular Biology and Genomics (BIOC 6600), College of Medicine
  • Epidemiologic Methods (EPID 5907) - Independent study
  • Statistical Analysis in Genetic Epidemiology (EPID 5907) - Independent study 
  • Linear Mixed Models (BSTA 6900) - Independent study    
  • Mixed Model in Clinical Trials and Survey Data (BSTA 6900) - Independent study
  • Mixed Model and Multivariate Analysis in Clinical Trials (BSTA 6900) - Independent study
  • Statistical Analysis of Clinical Trials Using SAS (BSTA 6900) - Independent study

RESEARCH INTERESTS

Biostatistics (Linear and non-linear mixed models, longitudinal data analysis, survival analysis, principal component analysis and factor analysis, latent class analysis, structural equation modeling, Bayesian analysis, and meta-analysis); Chronic Disease Epidemiology and Social-Behavioral Epidemiology; Genetic Epidemiology and Statistical Genetics (including bioinformatics, epigenetics, population genetics, and quantitative genetics)

CURRENT RESEARCH TOPICS

  1. Impacts of health behaviors, health care, and mental health on cancer screening
  2. Secondary data analysis of drug abuse treatment outcomes in NIDA clinical trial data
  3. Relationships between early alcohol and substance use and adult chronic diseases
  4. Genetic and epigenetic epidemiology of complex diseases including alcohol use disorder, Alzheimer’s disease, cancer, diabetes, HCV and HIV, and oral diseases
  5. Integrative analysis of SNP, exome sequence, methylation, and RNA expression in complex diseases

RESEARCH PROJECTS 

  1. ATR isomerization in cellular responses to UV damage of DNA. NIH R01, 2017-2022. Role: Co-I.
  2. Tim-3-mediated IL-12 dysregulation in antiviral response to HCV infection. NIH R01, 2012-2018. Role: Co-I.
  3. Barriers to Patient Shielding in Medical Imaging. American Society of Radiologic Technologists (ASRT) Foundation, 2016-2017. Role: Co-I.
  4. How Stribild action as an HIV antiretroviral drug is affected by genetic variations among patients. RDC, 2015-2016. Role: Co-I.
  5. The role of NK cells in immunodysregulation by hepatitis C virus. NIH R15, 2013-2016. Role: Co-I.
  6. Age differences in the associations of social and behavioral factors with stroke. RDC, 2012-2013. Role: Co-I.
  7. Gender differences and parental influence in genetic association analysis of alcohol dependence in the COGA sample. RDC, 2010-2011. Role: PI.
  8. Impact of clinic decision on the rapidity of blood pressure goal attainment. RDC, 2009-2010. Role: Co-I.

SELECTED PUBLICATIONS

  1. Wang KS, Chen X, Ward SC, Liu Y, Ouedraogo Y, Xu C, Cederbaum AI and Lu Y (2018) CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. International Journal of Obesity (Accepted).
  2. Chen Y, Xu C, Harirforoosh S, Luo X and Wang KS (2018) Analysis of PTPRK polymorphisms in association with the risk and age at onset of Alzheimer's disease, cancer risk, and cholesterol. Journal of Psychiatric Research 96:65-72.
  3. Wang KS, Liu Y, Xu C, Liu X and Luo X (2017) Family-based association analysis of NAV2 gene with the risk and age at onset of Alzheimer's disease. Journal of Neuroimmunology 310:60-65.
  4. Wang KS, Liu Y, Gong S, Xu C, Xie X, Wang L and Luo X (2017) Bayesian Cox proportional hazards model in survival analysis of HACE1 gene with age at onset of Alzheimer's disease. International Journal of Clinical Biostatistics and Biometrics 3(1):014.
  5. Chen G, Zhang F, Xue W, Wu R, Xu H, Wang KS and Zhu J (2017) An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count. Addiction Biology 22(6):1475-1485.
  6. Pan Y, Metsch LR, Wang W, Wang KS, Duan R, Kyle TL, Gooden LK and Feaster DJ (2017) Gender differences in HIV sexual risk behaviors among clients of substance use disorder treatment programs in the U.S. Archives of Sexual Behavior 46(4):1151-1158.
  7. Wang KS, Liu X, Ategbole M, Xie X, Liu Y, Xu C, Xie C and Sha Z (2017) Generalized linear mixed model analysis of urban-rural differences in social and behavioral factors for colorectal cancer screening. Asian Pacific Journal of Cancer Prevention 18(9):2581-2589.
  8. Wang KS, Liu Y, Xie X, Gong S, Xu C and Sha Z (2017) Principal component regression analysis of nutrition factors and physical activity with diabetes. Journal of Biometrics and Biostatistics 8(4): 364.
  9. Li L, Gong S, Xu C, Zhou JY and Wang KS (2017) Sleep duration and smoking are associated with coronary heart disease among US adults with type 2 diabetes: gender differences. Diabetes Research and Clinical Practice 124:93-101.
  10. Liu Y, Wang KS, Maisonet M, Wang L and Zheng S (2017) Associations of lifestyle factors (smoking, alcohol consumption, diet and physical activity) with type 2 diabetes among American adults from National Health and Nutrition Examination Survey (NHANES) 2005-2014. Journal of Diabetes 9(9):846-854.
  11. Wang KS and Xu C (2017) Applications of next-generation sequencing in cancer research and molecular diagnosis. Journal of Clinical and Medical Genomics 5(1):147.
  12. Wang KS, Liu X, Pan Y, Owusu D and Xu C (2017) Comparison of Cox regression and parametric models for survival analysis of genetic variants in HNF1B gene related to age at onset of cancer. Journal of Data Science 15(3):423-442.
  13. Zhou J, Yang X, Ning S, Wang L, Wang KS, Zhang Y, Yuan F, Li F, Zhuo D, Tang L and Zhou D (2017) Identification of KANSARL as the first cancer predisposition fusion gene specific to population of European ancestry origin. Oncotarget 8(31):50594-50607.
  14. Owusu D, Pan Y, Xie C, Harirforoosh S and Wang KS (2017) Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension. Journal of Psychiatric Research 84:27-34.
  15. Gong S, Xu C, Wang L, Liu Y, Owusu D, Bailey BA, Li Y and Wang KS (2017) Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol. Diabetes Research and Clinical Practice 126:105-114.
  16. Wang L, Southerland J, Wang KS, Bailey B, Alamian A, Stevens M and Wang Y (2017) Ethnic differences in risk factors for obesity among adults in California, the United States. Journal of Obesity 2017:2427483.
  17. Liu Y, Sayam S, Shao X, Wang KS, Zheng S, Li Y, Wang L (2017) Prevalence of diabetes and its trend among veterans in the United States, 2005-2014. Preventing Chronic Disease 14:170230.
  18. Owusu D, Quinn M, Wang KS, Aibangbee J and Mamudu HM (2017) Intention to quit tobacco smoking in 14 low-and middle- income countries based on the transtheoretical model. Drug and Alcohol Dependence 178:425-429.
  19. Wang KS (2016) Linear and non-linear mixed models in longitudinal studies and complex survey data. Journal of Biometrics and Biostatistics 7(2):e290.
  20. Wang KS, Liu X, Xie C, Liu Y and Xu C (2016) Non-parametric survival analysis of EPG5 gene with age at onset of Alzheimer's disease. Journal of Molecular Neuroscience 60(4):436-444.
  21. Zuo L, Tan Y, Wang Z, Wang KS, Zhang X, Chen X, Li CR, Wang T and Luo X (2016) Long noncoding RNAs in psychiatric disorders. Psychiatry Genetics 26(3):109-16.
  22. Wang KS, Owusu D, Pan Y and Xie C (2016) Bayesian logistic regression in detection of gene x steroid interaction for cancer at PDLIM5 locus. Journal of Genetics 95(2): 331-340.
  23. Wang KS, Liu Y, Gong S, Pan Y, Wang L and Xie C (2016) Model selection in survival analysis of EXT2 gene polymorphisms with age at onset of type 2 diabetes. International Journal of Bioinformatics and Biological Systems 1(1):1-9.
  24. Wang KS, Pan Y and Xu C (2015) Statistical modeling of microRNA expression with human cancers. Journal of Biometrics and Biostatistics 6(2):e240.
  25. Wang KS, Liu X and Wang L (2015) Beliefs about cancer and knowledge of genetic testing are associated with cancer information seeking behavior: Findings from the 2012 Health Information National Trends Survey. Annals of Public Health and Research 2(3):1025.
  26. Wang KS, Zuo L, Pan Y, Xie C and Luo X (2015) Genetic variants in the CPNE5 gene are associated with alcohol dependence and obesity in Caucasian populations. Journal of Psychiatric Research 71:1-7.
  27. Wang L, Wang KS, Gao X, Paul TK, Cai J and Wang Y (2015) Sex differences in the association between obesity and asthma in U.S. adults: Findings from a national study. Respiratory Medicine 109(8):955-62.
  28. Zuo L, Zhang CK, Sayward F, Cheung KH, Wang KS, Krystal JH, Zhao H, Luo X (2015) Gene-based and pathway-based genome-wide association study of alcohol dependence. Shanghai Arch Psychiatry. 27(2):111-118.
  29. Wang KS, Liu X and Wang L (2014) Associations of alcohol consumption and mental health with the prevalence of arthritis among US adults: Data from the 2012 National Health Interview Survey. Rheumatology International 34(9):1241-9.
  30. Wang KS, Liu X and Wang L (2014) Age and gender differences in the association between serious psychological distress and cancer: Findings from the 2003, 2005, and 2007 Health Information National Trends Surveys (HINTS). American Journal of Cancer Science 3(1):54-66.
  31. Wang KS and Liu X (2013) Integrative analysis of genome-wide expression and methylation data. Journal of Biometrics and Biostatistics 4(1):e123 (Has been cited for 5 times).
  32. Wang KS, Wang L, Liu X and Zeng M (2013) Association of HS6ST3 gene polymorphisms with obesity and triglycerides: gene-gender interaction. Journal of Genetics 92(3):395-402 (Has been cited for 4 times).
  33. Xu C, Aragam N, Li X, Villla EC, Wang L, Posada Y, Arana TB, Cruz G, Mao CX, Escamilla MA and Wang KS (2013) BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies. PLOS ONE 8(1):e51674 (Has been cited for 29 times).
  34. Wang JM, Ma CJ, Ji XJ, Wu XY, Wang KS, Thayer P, Moorman JP and Yao ZQ (2013) Differential regulation of IL-12/IL-23 by Tim-3 drives TH17 cell development during HCV infection. Journal of Virology 87(8):4372-4383 (Has been cited for 31 times).
  35. Moorman JP, Wang JM, Zhang Y, Ji XJ, Ma CJ, Wu XY, Jia ZS, Wang KS and Yao ZQ (2012) Tim-3 pathway controls regulatory and effector T cell balance during HCV infection. Journal of Immunology 189(2):755-766 (Has been cited for 87 times).
  36. Wang KS, Liu X, Zhang Q, Wu LY and Zeng M (2012) Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms. Journal of Neural Transmission 119(4):425-433 (Has been cited for 26 times).
  37. Wang KS, Liu X, Zhang QY, Pan Y, Aragam N and Zeng M (2011) Meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence. Journal of Psychiatric Research 45(11):1419-1425 (Has been cited for 58 times).
  38. Wang KS, Liu X and Aragam N (2010) A genome-wide meta-analysis identifies loci associated with schizophrenia and bipolar disorder. Schizophrenia Research 124(1-3):192-199 (Has been cited for 143 times).
  39. Wu LY, Chipman HA, Bull S, Briollais L and Wang KS (2009) A Bayesian segmentation approach to ascertain copy-number variations at the population level. Bioinformatics 25(13):1669-1679 (Has been cited for 25 times).
  40. Wallis RH, Wang KS, Dabrowski D, Marandi L, Ning T, Murphy T, Hsieh E, Paterson AD and Poussier P (2009) Type 1 diabetes in the BB rat: a polygenic disease. Diabetes 58(4):1007-1017 (Has been cited for 77 times).

SELECTED PRESENTATIONS

 

  1. Wang KS (2017) Family-based genome-wide association study identified novel loci associated with major depressive disorder and Alzheimer's disease. Second Meeting of The Oversea Chinese Association for Psychiatric Diseases at Beijing HuiLongGuan Hospital, Beijing, China
  2. Wang KS, Liu Y, Wang N, Elom H, Xie X and Wang L (2017) Weighted principal component regression analysis of cancer information seeking behaviors with colorectal cancer screening. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  3. Wang KS, Liu X, Liu Y, Choksi C, Xu C and Xie C (2017) Longitudinal study of treatment effects on opioid dependence using linear mixed models in a clinical trial. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  4. Wang KS, Liu Y, Liu X, Gong S, Xu C and Luo X (2017) Genetic variants in DOK5 gene are associated with obesity, type 2 diabetes, risk and age at onset of Alzheimer's disease. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  5. Elom H, Nwabueze C, Liu Y and Wang KS (2017) Prevalence and risk factors of hypertension among cocaine-dependent individuals in a multi-centered clinical trial. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  6. Liu Y, Wang KS, Sayam S and Zheng S (2017) Prevalence of diabetes and its trend in U.S. veterans, 2005-2014. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  7. Ouedraogo Y, Liu Y, Lu Y and Wang KS (2017) Pleiotropic effects of single nucleotide polymorphophisms of EDIL3 gene: Association with cancer, obesity, and type 2 diabete. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  8. Odame E, Silver K, Hffman K, Kelly M and Wang KS (2017) Comparative prevalence of Heat-related illnesses (HRIs) in outdoor and indoor tomato workers. The American Public Health Association (APHA) 145th Annual Meeting, Atlanta, USA.
  9. Ategbole M and Wang KS (2017) COPD as a risk factor for coronary heart disease: results from the 2015 National Health Interview Survey. 2017 Appalachian Student Research Forum.
  10. Choksi C, Wang KS, Liu Y, Oni O, Ouedraogo Y and Zheng S (2017) Effects of buprenorphine and methadone on hypertension in patients with opioid dependence: A randomized clinical trial study. 2017 Appalachian Student Research Forum.
  11. Ategbole M and Wang KS (2016) Associations of early smoking onset and past year tobacco use with the prevalence of bronchitis in US adults: Results from the 2013 National Survey on Drug Use and Health data. The American Public Health Association (APHA) 144th Annual Meeting, Denver, USA.
  12. Wang KS, Xu C, Liu Y, Ategbole M, Xie C, Zhang Z, Liu X and Luo X (2016) A genome-wide gene-steroid interaction study for type 2 diabetes in a Caucasian sample. The American Public Health Association (APHA) 144th Annual Meeting, Denver, USA.
  13. Wang KS, Ategbole M, Xie X, Liu Y, Xu C and Xie C (2016) Generalized linear mixed model analysis of potential factors for colorectal cancer screening in California adults. The American Public Health Association (APHA) 144th Annual Meeting, Denver, USA.
  14. Wang KS, Gong S, Sha Z, Ategbole M, Wang L and Liu Y (2016) A multilevel analysis of the influences of early alcohol consumption and daily cigarette use on the lifetime prevalence of pneumonia among U.S. adults. The American Public Health Association (APHA) 144th Annual Meeting, Denver, USA.
  15. Osazee J and Wang KS (2016) The association of respiratory diseases with colon cancer screening: Results from the 2014 National Health Interview Survey. 2016 Appalachian Student Research Forum.
  16. Ikekwere J, Igwacho J, Aragam N, Liu Y and Wang KS (2016) Associations of alcohol consumption and marijuana use with major depression episode: Results from the 2011 National Survey on Drug Use and Health data. 2016 American Psychiatric Association Conference, Atlanta, GA.
  17. Wang KS, Owusu D, Zuo L, Pan Y, Liu X, Li Y and Luo X (2015) A genome-wide association study identifies cancer-associated genes CTNNA3 and KCNIP1 contributing to alcohol dependence. The American Public Health Association (APHA) 143th Annual Meeting, Chicago, USA.
  18. Gong S, Xu C, Wang L, Li Y and Wang KS (2015) Association of PSD3 gene polymorphisms with obesity in two Caucasian samples. The American Public Health Association (APHA) 143th Annual Meeting, Chicago, USA.
  19. Owusu D, Pan Y, Quinn M, Wang KS (2015) Race differences in the associations of alcohol and illicit drug use with the prevalence of asthma in US adults: Results from the 2011 The National Survey on Drug Use and Health data. The American Public Health Association (APHA) 143th Annual Meeting, Chicago, USA.
  20. Kakraba S and Wang KS (2015) Associations of alcohol consumption and skin allergy with non-melanoma skin cancer: Findings from the 2012 National Health Interview Survey. 2015 Southeast Regional IDeA Conference, Biloxi, Miss, USA.
  21. Owusu D, Longcoy J, Quinn M and Wang KS (2014) Chronic disease conditions and colon cancer screening: Analysis of the 2012 National Health Interview Survey (NHIS) data. 2014 Appalachian Student Research Forum.
  22. Li WF and Wang KS (2012) Association between early drinking age and the development of alcohol dependence. 2012 Appalachian Student Research Forum.

 

PERSONAL INTERESTS

Reading, Traveling, Walking, Gardening

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