Two ETSU faculty members co-author book chapter on depression, suicide


JOHNSON CITY (November 26, 2014) – Two faculty members at East Tennessee State University recently co-authored a chapter for a text book on depression and suicide.

Dr. Michelle Chandley, a professor in the Department of Health Sciences in the College of Public Health, and Dr. Greg Ordway, a professor in the Department of Medical Sciences in the Quillen College of Medicine, wrote the chapter titled, “The noradrenergic system in depression and suicide” for the book, Concise Guide to Understanding Suicide: Epidemiology, Pathophysiology and Prevention.

The book was published this year by Cambridge University Press.

The chapter written by Chandley and Ordway was created to summarize the information currently known about the role of the neurotransmitter known as norepinephrine in the pathology and treatment of depressive disorders that lead to suicide.

Suicide, it explains, is the outcome of a complex interplay of factors that include both environmental and genetic influences. A common thread between the two is abnormalities found in the norepinephrine signaling pathway in those who commit suicide.

The chapter discusses norepinephrine pathology in people who have died by suicide and how current drug treatments for suicide ideation or depression alter norepinephrine signaling that result in behavioral improvement. It also explores the future direction of norepinephrine research in depression and suicide, including a better understanding of noradrenergic interactions with other cell types such as excitatory neurons.

More about the book can be found by visiting,

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