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Bill Gatton College of Pharmacy

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Zachary  Walls 

Adjunct Associate Professor
423-439-6236 /
Building 7, Room 319


As the leader of the multi-disciplinary Sub-Cellular Pharmaceutics Laboratory (SCPL), Zac is interested in a variety of drug-targeting strategies. One of the main efforts of the lab is designing organelle-specific drug delivery systems for therapeutic macromolecules. Research conducted in the lab is supported by the RDC, ETSU Honors College, and AACP.

Education, Degree, & Post Graduate Training:

  • Post-Doctoral Researcher, University of Michigan, 2008-2011
  • Visiting Researcher, Stanford University, 2003-2007
  • PhD, University of California Los Angeles, 2001-2007
  • BS, Tulane University, 1998-2001

Classes taught:

Biopharmaceutics & Biotechnology; Immunology

Research Interests:

Sub-cellular pharmaceutics, non-viral gene therapy, molecular imaging

Selected Publications:

  1. Walls ZF, Gong H, Wilson RJ. “Liposomal Coencapsulation of Doxorubicin with Listeriolysin O Increases Potency via Subcellular Targeting.” Mol Pharm. 13(3):1185-90, 2016.
  2. Walls ZF, Gupta SV, Amidon GL, Lee KD. “Synthesis and Characterization of Valyloxy Methoxy Luciferin for the Detection of Valacyclovirase and Peptide Transporter.” Bioorg Med Chem Lett. 24(20):4781-3. 2014.
  3. Walls ZF, Goodell S, Andrews CD, Mathis J, Lee KD. "Mutants of Listeriolysin O for Enhanced Liposomal Delivery of Macromolecules." J Biotechnol. 164(4):500-502, 2013.
  4. Loening AM, Walls ZF. "Engineering Luciferases for Assays and Imaging." Engineering in Translational Medicine. Ed. Cai W. Springer, 2014.

Organizational Involvement/Membership:

  • American Association of Pharmaceutical Scientists (AAPS)
  • World Molecular Imaging Society (WMIS)
  • American Association of Colleges of Pharmacy (AACP)
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