Mrs. Self was a member of the faculty of the ETSU Department of Music. She served two terms as president of the Friends of Music. She established the Virgil Self Memorial Endowment in honor of her late husband, who was chairman of the music department. The endowment was made possible from revenue of Music Times, a music book for elementary school use written by Mrs. Self. The proceeds from the endowment are being used for scholarships for music majors at ETSU.