Toxicology

 

Faculty and staff of the ETSU Toxicology Laboratory participate in many research projects, both original and in collaboration with other investigators. A partial list of publications arising from these varied areas of research include:


Ferslew, K.E., Daigneault, E.A., Aten, E.M., and J.M. Roseman: 
Pharmacokinetics and UrinaryExcretion of Clavulanic Acid After Oral Administration of Amoxicillin and Potassium Clavulanate. The Journal of Clinical Pharmacology 24:452-456 (1984). 

Daigneault, E.A., Ferslew, K.E., Aten, E.M. and J.M. Roseman: 
Comparison of the Pharmacokineticsand Urinary Excretion of Clavulanic Acid After Oral Administration of Augmentin Using HighPerformance Liquid Chromatographic and Microbiological Assays. Postgraduate Medicine: CustomCommunications, September/October:169-175 (1984). 

Ferslew, K.E., Orcutt, R.H. and A.N. Hagardorn:  
Spectral Differentiation and GasChromatographic/Mass Spectrometric Analysis of the Lacrimators, 2-Chloroacetophenone and0-Chlorobenzylidene Malononitrile. Journal of Forensic Sciences 31:658-665 (1986). 

Moffatt, E.J., Hagardorn, A.N. and K.E. Ferslew: A Gas-Liquid Chromatographic Method forQuantitation of 1,3-Butylene Glycol in Whole Blood or Plasma and the Separation of the ShortChain Glycols. Journal of Analytical Toxicology 10:35-37 (1986). 

Woodall, G.M., Pancorbo, O.C., Blevins, R.D. and K.E. Ferslew: 
Mutagenic Activity Associated withCooling Tower Waters Treated with a Biocide Containing 5-Chloro-2-Methyl-4-Isothiazolin-3-one. Environmental Science and Technology 21:815-820 (1987). 

Daigneault, E.A., Ferslew, K.E. and P. Stanton: 
Bioavailability of Nabumetone and Pharmacokineticsof the Principal Metabolite, 6-Methoxy-Naphthylacetic Acid. The American Journal of Medicine83, Suppl. 4B:11-14 (1987). 

Dunbar, J.R., DeLucia, A.J., Acuff, R.V. and K.E. Ferslew:  
Prolonged Intravenous Paraquat Infusionin the Rat. I. Failure of Coinfused Putrescine to Attenuate Pulmonary Paraquat Uptake, ParaquatInduced Biochemical Changes or Lung Injury. Toxicology and Applied Pharmacology94(2):207-220 (1988). 

Dunbar, J.R., DeLucia, A.J., Acuff, R.V. and K.E. Ferslew: 
Prolonged Intravenous Paraquat Infusionin the Rat. II. Paraquat Induced Alterations in Lung Polyamine Metabolism.Toxicology andApplied Pharmacology 94(2):221-226 (1988). 

Barron, S.E., Daigneault, E.A. and K.E. Ferslew:  
The Comparison of Cisplatin Induced Ototoxicity andPlatinum Serum Concentrations. Journal of the Tennessee Speech-Language-Hearing Association30:16-20 (1988). 

Acuff, R.V., Ferslew, K.E., Daigneault, E.A., Orcutt, R.H., Thedford, S.S. and P.E. Stanton:  Pharmacokinetic Modeling and Bioavailability of RRR and All-Racemic Alpha-Tocopheryl Acetatein Human Blood Components. In Vitamin E and Health Implications, Annals of the New YorkAcademy of Sciences 570: 406-408 (1989). 

Acuff, R.V., Ferslew, K.E., Daigneault, E.A., Orcutt, R.H., Thedford, S.S. and P.E. Stanton:  Pharmacokinetic Modeling and Bioavailability of RRR and All Racemic Alpha Tocopheryl Acetatein Human Blood Components. American Journal of Clinical Nutrition. (Accepted, in revision1990). 

Barron, S.E., Perry, J.R. and K.E. Ferslew:  
The Effect of Ibuprofen on Ethanol Concentration and Elimination Rate. Journal of Forensic Sciences 37(2):432-435 (1992). 

Marshall, D.E., Hagardorn, A.N. and K.E. Ferslew: 
GC/MS Method for the Determination of Flumazenilin Plasma and Urine. Research Communications in Substances of Abuse 12(4):228-236 (1992). 

Marshall, D.E., Hagardorn, A.N. and K.E. Ferslew:  
Evaluation of Chromatographic and ImmunologicalMethods for the Detection and Confirmation of Flumazenil, A Benzodiazepine Antagonist, in Urine. Research Communications In Substances of Abuse 12(4):217-227 (1992). 

Cox, S.K., Ferslew, K.E. and L.J. Boelen:  
The Toxicokinetics of 1,3-Butylene Glycol Versus Ethanolin the Treatment of Ethylene Glycol Poisoning. Veterinary and Human Toxicology 34(1):36-42(1992). 

Ferslew, K.E., Acuff, R.V., Daigneault, E.A., Woolley, T.W. and P.E. Stanton:  
Pharmacokinetics andBioavailability of the RRR and All Racemic Stereoisomers of Alpha-Tocopherol in Humans AfterSingle Oral Administration. Journal of Clinical Pharmacology 33:84-88 (1993). 

Daigneault, E.A., Hamdy, R.C., Ferslew, K.E., Rice, P.J., Singh, J., Harvill, L.M. and J.H. Kalbfleisch: 
Investigation of the Influence of Acetylsalicylic Acid on the Steady State of Long-Term Therapywith Theophylline in Elderly Male Patients With Normal Renal Function. Journal of ClinicalPharmacology 34:86-90 (1994). 

Orcutt, R.H., Thurmond, T.S. and Ferslew, K.E.:  
Mathematical Modeling of Osmotic Fragility of Rabbit Red Blood Cells. Journal of Pharmacological and Toxicological Methods 34:169-174 (1995). 

Thurmond, T.S., Ferslew, K.E., Orcutt, R.H. and P.S. Coogan: 
In Vitro Effects of Estradiol andIndomethacin on Rabbit Erythrocyte Fragility Characteristics. Toxicology In Vitro, 10:43-49(1996). 

Thurmond, T.S., Ferslew, K.E., McCracken, M.D. and P.S. Coogan: 
The Effect of IndomethacinAdministration on the Splenic Changes Induced by Estradiol Supplementation in Ovariectomized New Zealand White Rabbits. Toxicologic Pathology, 24(2):153-159 (1996). 

Panus, P.C., Tober-Meyer, B. and K.E. Ferslew: 
Tissue Extraction and High-Performance LiquidChromatographic Determination of Ketoprofen Enantiomers. Journal of Chromatography, B,Biomedical Applications, 705: 295-302 (1998). 

Panus, P.C., Ferslew, K.E., Atanasoska, L., Tober-Meyer, B. and R.L. Kao: 
Ketoprofen TissuePermeation in Swine Following Cathodic Iontophoresis. Physical Therapy, 79(1): 40-49 (1999). 

Long, T.L., Rice, P.J., Nwosu, U.C., Jelovsek, F.R., and Ferslew, K.E.: 
Cocaine Potentiates the Vasoconstrictive Effects of Serotonin, Norepinephrine, and Tyramine on the Human Umbilical Artery. Toxicology and Applied Pharmacology (submitted, 1998). 

Creson, T., Monaco, P.J., Rasch, E.M., Hagardorn, A.N., and Ferslew, K.E.: 
Capillary Ion Analysis of Lithium Concentrations in Biological Fluids and Tissues of Poecilia (Teleost). Electrophoresis, 19: 3018-3021 (1998). 

Blackford, J., Doherty, T.J., Ferslew, K.E. and Panus, P.: 
Iontophoresis of dexamethasone Sodium Phosphate into the Equine Tibiotarsal Joint. J Veterinary Pharmacology and Therapeutics 23:229-236 (2000). 

Leeper, S.C., Almatari, A.L., Ingram, J.D. and Ferslew, K.E.: 
Topical Absorption of Isopropyl Alcohol - Induced Cardiac and Neurological Deficits in an Adult female with Intact Skin.Veterinary & Human Toxicology 42(1): 15-17 (2000). 

Wondergem, R., Gong, W., Monen, S.H., Dooley, S.N., Gonce, J.L., Conner, T.D., Houser, M., Ecay, T.W., and Ferslew, K.E:   
Membrane Chloride Currents and Liver Cell Proliferation.  Blocking Volume-Activated Chloride Current Inhibits Liver Cell Proliferation.  J. Physiology. 532: 661-672 (2001). 

Eastman, T., Honnas, C.M., Ferslew, K.E., Blackford, J.,Doherty, T.J. and Panus, P.C.:   Cathodic Iontophoresis of Ketoprofen over the Equine Middle Carpal Joint.  Equine Veterinary Journal 33(6):614-616 (2001). 

Creson, T.K., Woodruff, M.L., Ferslew, K.E., Rasch, E.M., and Monaco, P.J.: Dose-Response Effects of Chronic Lithium Regimens on Spatial Memory in the Black Molly Fish. Pharmacology, Biochemistry and Behavior 75(1):35-47 (2003) 

Yin, D., Woodruff, M., Zhang, Y., Whaley, S., Miao, J., Ferslew, K., Zhao, J., and Stewart, C.: 
Morphine Promotes Jurkat Cell Apotosis Through Pro-apoptotic FADD/P53 and Anti-apoptotic P13K/Akt/NF-κB Pathways.Journal of Neuroimmunology 174:101-107 (2006). 

Yarrobino, T.E., Kalbfleisch, J.H., Ferslew, K.E., and Pannus, P.C.: 
Lidocaine Iontophoresis Mediates Analgesia in Lateral Epicondylalgia Treatment. Physiotherapy Research International 11(3):152-160 (2006). 

Miller, M.N., Newell, C.L., Miller, B.E., Frizzell, P.G., Kayser, R.A. and Ferslew, K.E.: 
Variable Dosing of Sertraline for Premenstrual Exacerbation of Depression: A Pilot Study. Journal of Women's Health 17(6):993-7 (2008). 

Li, Y., Sun, X., Huang, J., Hanley, G., Ferslew, K.E., Peng, Y. and Yin, D.: 
Morphine Promotes Apoptosis Via TLR2, and This is Negatively Regulated by Beta-Arrestin 2.
 Biochemical and Biophysics Research Communications, 378:857-861 (2009). 

Xie, N., Li, H., Wei, D., LeSage, G., Chen, L. Wang, S., Zhang, Y., Chi, L., Ferslew, K., He, L., Chi, Z., and D. Yin: Glycogen Synthase Kinase-3 and p38 MAPK are Required for Opiate-Induced Microglia Apoptosis. Neuropharmacology, 59(6):444-451 (2010).

Wright, T., Ferslew, K.E.: 
Biotransformation of Ethanol to Ethyl Glucuronide in a Rat Model After a Single High Oral Dosage. Alcohol, 46:159-164 (2011).


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