Katalin Szebeni, M.D.
Department of Biomedical Sciences
Katalin Szebeni, M.D.
Assistant Professor, Department of Biomedical Sciences
James H. Quillen College of Medicine
PO Box 70582
Stanton-Gerber Hall (VA 178)
Room B-237, Lab A-204
Johnson City, TN 37601
Dr. Szebeni is research assistant professor of Biomedical Sciences at the Quillen College of Medicine in Johnson City, Tennessee. She received her M.D. degree at the University of Albert Szent-Györgyi Medical University. She has a long-term interest in molecular and cellular mechanisms of diseases, like cystic fibrosis, diabetes, and brain diseases. Her previous clinical experience provides an excellent background to understand links between biomedical research and clinical medicine. As a physician-oriented scientist, her interests have focused most recently on the pathological mechanisms involved in major depression. She has an extensive understanding of human brain anatomy and histological methods to aid in the definition of brain cells and regions, expertise that is particularly useful in brain research. She has over ten years of professional experience in the field of biological psychiatry. She is also committed to training a new generation of young scientists, including mentoring medical, graduate or undergraduate students in the laboratory.
The main focus of my lab is to study molecular and cellular basis of clinical depression and the molecular mechanisms of antidepressant drugs.
I am a core team member of the Molecular Psychiatry team. Dr. Greg Ordway
Xiang L., Szebeni K., Szebeni A., Klimek V., Stockmeier, C.A., Karolewicz B., Kalbfleisch J. and Ordway, G.A.: Dopamine receptor gene expression in human amygdaloid nuclei: elevated D4 receptor mRNAs in depression. Brain Res.1207: 214-224, 2008.
Karolewicz B., Szebeni K., Gilmore T., Maciag D., Stockmeier C.A. and Ordway G.A. Elevated levels of NR2A and PSD-95 in the lateral amygdala in depression. Int. J. Neuropsychopharm., 23: 1-11, 2009.
Ordway G.A., Szebeni A., Duffourc M.M., Dessus-Babus S. and Szebeni K.: Gene expression analyses of neurons, astrocytes, and oligodendrocytes isolated by laser capture microdissection from human brain: Detrimental effects of laboratory humidity. J. Neurosci. Res., 87: 2430-2438, 2009.
Brown R.W., Noel D.M., Smith J.J., Smith M.L., Huggins K.N., Szebeni K., Szebeni A., Duffourc M., Chandley M., and Ordway G.A.: Eszopiclone Facilitation of the Antidepressant Efficacy of Fluoxetine Using a Social Defeat Stress Model. Pharmacol., Biochem. and Behav., 99: 648-658, 2011.
Ordway G.A., Szebeni A., Chandley M.J., Stockmeier C.A., Xiang L., Newton S.S., Turecki G., Duffourc M., Zhu M.-Y., Zhu H., and Szebeni K.: Reduced gene expression of bone morphogenetic protein 7 in brain astrocytes in major depression. Int. J. Neuropsychopharmacology, 15: 855-868, 2012.
Chandley M.J., Szebeni K., Szebeni A., Stockmeier C.A., Turecki G., Miguel-Hidalgo J.J., and Ordway G.A.: Gene expression deficits in pontine locus coeruleus astrocytes in men with major depressive disorder, J. Psychiatr. Neurosci., 38: 276-284, 2013.
Chandley M. J., Szebeni A., Szebeni K., Crawford J. D., Stockmeier C. A., Turecki G., Kostrzewa R. M. and Ordway G. A.: Elevated Gene Expression of Glutamate Receptors in Noradrenergic Neurons from the Locus Coeruleus in Major Depression. I nt. J. Neuropsychopharm. 2014, (in press).
Szebeni A., Szebeni K., DiPeri T., Chandley M. J., Crawford J. D., Stockmeier C. A., and Ordway G. A.: Telomere Shortening and Compensated Gene Expression of Oxidative Stress Defense Enzymes in White Matter Oligodendrocytes in Major Depression. I nt. J. Neuropsychopharm. Int. 2014, (in press).