Dr. Robert Wondergem

 

Dr. Robert Wondergem

 

 

                             
                                    Robert Wondergem, Ph.D.
                          Professor
                          Department of Biomedical Sciences

 

 

 

Contact Information:

Robert Wondergem, PhD
Professor of Physiology
Department of Biomedical Sciences
P.O. Box 70582
East Tennessee State University
Johnson City, TN 37614-1708
Phone: 423-439-2045
Email:

Street Address:
East Tennessee State University
James H. Quillen College of Medicine
Department of Biomedical Sciences
Stanton-Gerber Hall, Room B-138
Maple Avenue
Mountain Home, TN 37684

Education:

-B.S., 1972, Calvin College, Biology and Chemistry (General College)
-Ph.D., 1977, Medical College of Wisconsin, Physiology with Prof. H.M. Klitgaard
-Postdoctoral, 1977-78, University of Wisconsin-McArdle Laboratory for Cancer Research with Prof. Van Rensselaer Potter

Research Interests:

1.  Cellular Physiology
2.  Electrophysiology


Research centers on studying the relationship of membrane K,Cl and TRP-channels in cell proliferation and cell migration. [Key Words:  Cell Physiology; Hepatocytes; Tumor Cells; Electrophysiology; Biological Transport and Cell Volume Regulation; Intracellular Ion Activities; Membrane K+ and C1- Channels; Cellular Metabolism and Growth; Cell Motility; Hormone and Growth Factor Action].


Selected Publications: 

Wondergem, R., Bartley, J.W. (2009).  Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration.  Journal of Biomedical Science 16, 90. http://www.ncbi.nlm.nih.gov/pubmed/19778436

Wondergem, R., Graves, B.M., Ozment-Skelton, T.R., Li, C., Williams, D.L. (2010). Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current I f in immortalized HL-1 cardiomyocytes. American Journal of Physiology:Cell Physiology 299, C665-C671.  http://www.ncbi.nlm.nih.gov/pubmed/20573997

Xie, Q., Wondergem, R., Shen, Y., Cavey, G., Ke, J., Thompson, R., Bradley, R., Daughtery-Holtrop, J., Xu, Y., Chen, E., Omar, H., Rosen,  N., Wenkert, D., Xue, H.E., and Vande Woude, G.F.  (2011).  Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.  Proc. Natl. Acad. Sci. USA. 108,  4105-4110. http://www.ncbi.nlm.nih.gov/pubmed/21368131

Graves, B.M., Simerly, T., Li, C., Williams, D.L. and Wondergem R.  (2012).  Phosphoinositide-3-kinase/Akt (PI3K/Akt) dependent signaling is required for maintenance of [Ca2+]i,  I Ca, and Ca2+  transients in HL-1 cardiomyocytes. Journal of Biomedical Science 19, 59. http://www.ncbi.nlm.nih.gov/pubmed/22715995

Wondergem, R. Graves, B.M., Li, C., and Williams D.L.   Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes.  American Journal of Physiology:Cell Physiology 303, C825-C833. http://www.ncbi.nlm.nih.gov/pubmed/22895260

Burt, R., Graves, B.M,, Gao, M., Li, C., Williams, D.L., Fregoso, S.P., Hoover. D.B., Li, Y., Wright, G.L., Wondergem, R. (2013). 9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes. Cell Calcium. 2013 Sep;54(3):193-201.  http://www.ncbi.nlm.nih.gov/pubmed/23831210

Wondergem, R. (2014). Intracellular renin-angiotensin signaling: Working from the inside-out in hypothalamic neurons.  American Journal of Physiology:Cell Physiology 306, C721-C723.  http://www.ncbi.nlm.nih.gov/pubmed/24429063

Hoover, D.B., Ozment, T.R., Wondergem, R., Li, C., and Williams, D.L. (2015).  Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis. Shock 43, 185-191.

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