Dr. Robert Wondergem


Dr. Robert Wondergem



                                    Robert Wondergem, Ph.D.
                             Department of Biomedical Sciences




Contact Information:

Robert Wondergem, PhD
Professor of Physiology
Department of Biomedical Sciences
P.O. Box 70,582
East Tennessee State University
Johnson City, TN 37614-1708
Phone: 423-439-2045

Street Address:
East Tennessee State University
James H. Quillen College of Medicine
Department of Biomedical Sciences
Stanton-Gerber Hall, Room B-138
Maple Avenue
Mountain Home, TN 37684


-B.S., 1972, Calvin College, Biology and Chemistry (General College)
-Ph.D., 1977, Medical College of Wisconsin, Physiology with Prof. H.M. Klitgaard
-Postdoctoral, 1977-78, University of Wisconsin-McArdle Laboratory for Cancer Research with Prof. Van Rensselaer Potter

Research Interests:

1.  Cellular Physiology
2.  Electrophysiology

Research centers on studying the relationship of membrane K,Cl and TRP-channels in cell proliferation and cell migration. [Key Words:  Cell Physiology; Hepatocytes; Tumor Cells; Electrophysiology; Biological Transport and Cell Volume Regulation; Intracellular Ion Activities; Membrane K+ and C1- Channels; Cellular Metabolism and Growth; Cell Motility; Hormone and Growth Factor Action].

Selected Publications: 

Wondergem, R., Ecay, T.W., Mahieu, F., Owsianik, G., and Nilius, B. (2008). HGF/SF and menthol increase human glioblastoma cell calcium and migration. Biochemical and Biophysical Research Communications 372, 210-215.  http://www.ncbi.nlm.nih.gov/pubmed/18485891

Wondergem, R., Bartley, J.W. (2009). Menthol increases human glioblastoma intracellular Ca2+, BK channel activity and cell migration. Journal of Biomedical Science 16, 90. http://www.ncbi.nlm.nih.gov/pubmed/19778436

Wondergem, R., Graves, B.M., Ozment-Skelton, T.R., Li, C., Williams, D.L. (2010). Lipopolysaccharides directly decrease Ca2+ oscillations and the hyperpolarization-activated nonselective cation current I f in immortalized HL-1 cardiomyocytes. American Journal of Physiology:Cell Physiology 299, C665-C671.  http://www.ncbi.nlm.nih.gov/pubmed/20573997

Xie, Q., Wondergem, R., Shen, Y., Cavey, G., Ke, J., Thompson, R., Bradley, R., Daughtery-Holtrop, J., Xu, Y., Chen, E., Omar, H., Rosen, N., Wenkert, D., Xue, H.E., and Vande Woude, G.F. (2011). Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion. Proc. Natl. Acad. Sci. USA. 108, 4105-4110. http://www.ncbi.nlm.nih.gov/pubmed/21368131

Graves, B.M., Simerly, T., Li, C., Williams, D.L. and Wondergem R. (2012). Phosphoinositide-3-kinase/Akt (PI3K/Akt) dependent signaling is required for maintenance of [Ca2+]i, I Ca, and Ca2+ transients in HL-1 cardiomyocytes. Journal of Biomedical Science 19, 59. http://www.ncbi.nlm.nih.gov/pubmed/22715995

Wondergem, R. Graves, B.M., Li, C., and Williams D.L.   Lipopolysaccharide prolongs action potential duration in HL-1 mouse cardiomyocytes. American Journal of Physiology:Cell Physiology 303, C825-C833.  http://www.ncbi.nlm.nih.gov/pubmed/22895260

Burt, R., Graves, B.M,, Gao, M., Li, C., Williams, D.L., Fregoso, S.P., Hoover. D.B., Li, Y., Wright, G.L., Wondergem, R. (2013). 9-Phenanthrol and flufenamic acid inhibit calcium oscillations in HL-1 mouse cardiomyocytes. Cell Calcium. 2013 Sep;54(3):193-201. http://www.ncbi.nlm.nih.gov/pubmed/23831210

Wondergem, R. (2014). Intracellular renin-angiotensin signaling: Working from the inside-out in hypothalamic neurons. American Journal of Physiology:Cell Physiology 306, C721-C723. http://www.ncbi.nlm.nih.gov/pubmed/24429063