Grave's disease

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Note that the patient's palpebral fissure is widened (Dalrymple's sign); the lids lag behind the globe on downward and upward motions (von Graefe's and Griffith's signs); the globe lags behind the lid on upward motion (Mean's sign); and the lid motion is "jerky" on downward motion (Boston's sign).
   All of these signs are evidence of lid retraction (spasm), most characteristic of thyroid hyperactivity, particularly Grave's disease.
   Other findings can include Stellwag's sign (infrequent blinking) and Rosenbach's sign (tremor of the closed eyelids).