Charles E. Ganote


Charles E. Ganote, M.D.

Phone: (423) 439-6210
Fax: (423) 439-8060


Medical School: Vanderbilt University School of Medicine


Fellowships: Research, Arthritis and Metabolic Disease, National Institutes of Health and National Heart Hospital, London, England. Sabbatical: Cardiac Pathology, National Institute of Health

Clinical Focus:

Autopsy Pathology; Cardiac and Pulmonary Pathology

Research Focus:

Ischemic Cellular, especially Cardiac Injury

Selected Publications:

Ganote CG and Armstrong SC. 2003. Effects of CCCP-induced mitochondrial uncoupling and cyclosporin A on cell volume, cell injury and preconditioning protection of isolated rabbit cardiomyocytes. J. Mol. Cell. Cardiol. 35: 749-759.

Armstrong SC, Latham CA, Shivell CL, Ganote CE. Ischemic loss of sarcolemmal dystrophin and spectrin: correlation with myocardial injury. J Mol Cell Cardiol 2001 Jun;33(6):1165-79.

Armstrong SC, Shivell LC, Ganote CE. Sarcolemmal blebs and osmotic fragility as correlates of irreversible ischemic injury in preconditioned isolated rabbit cardiomyocytes. J Mol Cell Cardiol 2001 Jan;33(1):149-60.

Armstrong SC, Shivell CL, Ganote CE. Differential translocation or phosphorylation of alpha B crystallin cannot be detected in ischemically preconditioned rabbit cardiomyocytes. J Mol Cell Cardiol 2000 Jul;32(7):1301-14.

Armstrong SC, Delacey M, Ganote CE. Phosphorylation state of hsp27 and p38 MAPK during preconditioning and protein phosphatase inhibitor protection of rabbit cardiomyocytes. J Mol Cell Cardiol 1999 Mar;31(3):555-6.

Weinbrenner C, Baines CP, Liu GS, Armstrong SC, Ganote CE, Walsh AH,Honkanen RE, Cohen MV, Downey JM. Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia. Circulation 1998 Sep 1;98(9):899-905.

Vander heide RS, Rim D, Hohl CM, Ganote CE 1990. An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes. J Mol Cell Cardiol. 22: 165-181.

Ganote, CE, Vander Heide, RS. 1988. Irreversible injury of isolated adult rat myocytes: Osmotic fragility during metabolic inhibition. Amer. J. Pathol., 132: 212-222.

Ganote, CE, Vander Heide, RS. 1987. Cytoskeltal lesions in anoxic myocardial injury: a conventional and high voltage electron microscopic and immunofluresecence study. Amer. J. Pathol., 129: 327-344.

Vander Heide RS, Ganote CE. 1987. Increased myocyte fragility following anoxic injury. J. Mol. Cell. Cardiol., 19: 1085-1103.