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Bill Gatton College of Pharmacy

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Chuck  Collins 

RPh, PhD
Professor
Contact:
423-439-2146 /
Building 7, Room 321

Since 1979 I have studied and conducted research in the area of pharmaceutics involving drug delivery system formulations, dissolution, and drug release. I began my faculty career on October 1, 1983. Being one of the few basic science faculty with a pharmacy degree and license, my teaching load has typically been a significant portion of my responsibilities. Though I have often found the time to conduct projects, I have not been able to maintain manuscript preparation and submissions. After several years of such frustration, I decided to change institutions and my role in education by joining a new program as a department chair and school administrator. The direction of that program significantly changed and in March 2006, and for the last time, I changed institutions; initially as an administrator but later changing to "just" an educator. After this change I found a renewed interest, and the time, to engage in research. Our college of pharmacy now has an extensive program that allows our pharmacy students to experience research and receive elective credit. During the past three years I have had 6 such students which allows me the necessary assistance to conduct significant research. We currently have three manuscripts in preparation from recent work. Since I personally brought a significant amount of dissolution and drug release equipment with me, acquired through grants and donations from previous years, I have been able to provide ETSU with the ability and expertise to conduct dissolution experiments. I am the only person on campus with this ability and as such was an integral part of the interdisciplinary grant given to the group headed by Dr. Andrew Clark. As this, and other drug delivery system tests such as content uniformity, are essential to the evaluation of the products, my lab is essential to the appropriate conduction of the vitamin D research projects. My lab is well positioned and provisioned to conduct this work.

Education, Degree, & Post Graduate Training:

  • Bachelor of Science in Pharmacy (B.S.) – West Virginia University – May15, 1977
  • Doctor of Philosophy (Ph.D.) – West Virginia University School of Pharmacy – May 19, 1984
  • Additional Certifications: (BCPS, etc..)
  • Registered Pharmacist (RPh) in West Virginia: August 1977 to present
  • Registered Pharmacist (RPh) in Pennsylvania: May 1984 to present
  • Doctor of Pharmacy (DPh) in Tennessee: June 2011 to present

Career highlights:

  • 2006 – Present, East Tennessee State University College of Pharmacy, Johnson City, TN
  • 2008-present: Professor of Pharmaceutical Sciences, member of the graduate faculty
  • 2006-2008: Associate Dean for Academic Affairs
  • 1998 – 2010, Consultant, Varian, Inc (was VanKel) Dissolution Systems, Cary, NC
  • 2000 – 2007, Consultant, Novavax, Inc., Rockville, Maryland
  • 2001 – 2006, Palm Beach Atlantic University School of Pharmacy, West Palm Beach, FL, Assistant Dean and Chair of the Department of Pharmaceutical Sciences; Professor of Pharmaceutical Sciences
  • 1998 July through December – Six month sabbatical, worked for VanKel Technology Group, Cary, North Carolina. (Now known as Agilent (was Varian, Inc.) Dissolution Systems, same address)
  • 1983 - 2001, Duquesne University, School of Pharmacy
  • 1990-2001: Associate Professor of Pharmaceutics with Tenure
  • 1983-1990: Assistant Professor of Pharmaceutics
  • 1983-2001: Member of the Graduate Faculty
  • 1985 - 1995, Children's Hospital of Pittsburgh: Staff Pharmacist (part-time)
  • 1981 - 1983, Monongalia General Hospital: Staff Pharmacist (part-time)
  • 1979 - 1981, Rite Aid Corporation: Weston, W.Va. Pharmacy, Pharmacist (part-time)
  • 1977 - 1979, Rite Aid Corporation: Madison, W.Va. Pharmacy, Pharmacist manager (full-time)

Teaching specialty:

Specific areas of teaching competence

  1. Pharmacy Calculations
  2. Pharmaceutical Principles
  3. Formulation and Development
  4. Dissolution Technology – Transdermal and Topical DDS evaluations
  5. Solubility of drug molecules
  6. Physics applications in pharmaceutics
  7. Biopharmaceutics of drugs and drug delivery systems
  8. Pharmacokinetics theory and clinical application
  9. Introduction to Microbiology

Classes taught:

Duquesne University

  • Pharmacy Math/Pharmaceutics, 3 cr.
  • Pharmacy Calculations, 2 cr.
  • Pharmaceutics II, 4 cr.
  • Pharmaceutics III/Biopharmaceutics 3 cr.
  • Pharmaceutics IV/Pharmacokinetics, 4 cr.
  • Clinical Pharmacokinetics and Advanced Parenteral Therapy
  • Physics for Pharmacists, 4 cr.
  • Integrated Case Studies I & II, 1 cr.
  • Seminar Pharmaceutical Chemistry I & II, 1 cr.
  • Veterinary Pharmacy (elective), 3 cr.
  • Graduate Courses (also electives)
  • Advanced Pharmacokinetics I & II, 3 cr.
  • Pharmacy Computer Applications 3 cr.
  • Advanced Pharmaceutics I & II, 3 cr.
  • Formulation and Development, 4 cr.

Palm Beach Atlantic University

  • Pharmaceutics I, 3 cr.
  • Pharmaceutics II with Lab, 3 cr.
  • Biopharmaceutics, 3 cr.
  • Pharmacokinetics, 3 cr.
  • Microbiology and Immunology, 4 cr.
  • Therapeutics (4 lecture hours) – Skin disorders (including skin cancer) and burns
  • Veterinary Pharmacy (elective), 3 cr.

East Tennessee State University

  • Pharmacy Calculations, 2 cr.
  • Pharmaceutics and Biopharmaceutics, 5 cr.
  • Pharmaceutics of Drug Delivery Systems, 2 cr.
  • Pharmacokinetics, 4 cr.
  • Compounding and Dispensing Lab, 1 cr.
  • IDEALS Lab I through VI
  • Communication Skills for Health Professionals, 3 cr.
  • Veterinary Pharmacy, 2 cr.

Research Interests:

Specific areas of research interest

Development and usage of in vitro drug release from transdermal and topical dosage forms as a method of quality control
High Performance Liquid Chromatography analysis of drug substances
Pharmacokinetic analysis of drug disposition
Development and in vitro testing of prolonged/sustained release dosage forms
     a) For oral administration
     b) Microencapsulation for injection
     c) For buccal administration
Use and comparison of in vitro dissolution instruments
     a) Standard and controlled release drug delivery systems
     b) Topical and transdermal drug delivery systems
Polymer usage in controlled release dosage forms and as bioadhesives
In vitro and in vivo pharmacokinetic correlations
Pharmaceutical excipient evaluations (mainly direct compression)

Selected Publications:

G. Wong and C. C. Collins, "Chapter 4.4 Dissolution Testing" in Preformulation in Solid Dosage Form Development, Editors: M. C. Adeyeye and H. G. Brittain,
Informa Healthcare USA, Inc., pages 477-555, 2008.).

Marilyn Martinez and Charles Collins "Use of In vitro Dissolution Testing Procedures for Veterinary Drug Products. Part I. The potential role of in vitro dissolution testing for products intended for multiple animal species." Controlled Release Society Newsletter, Volume 19, Number 3, 2002, pages 17-18.

Marilyn Martinez and Charles Collins "Use of In vitro Dissolution Testing Procedures for Veterinary Drug Products. Part II. The potential role of in vitro dissolution testing for products intended for multiple animal species." Controlled Release Society Newsletter, Volume 20, Number 1, 2003, pages 19-25.

S. P. Desselle, C. C. Collins, M. W. Harrold, M. M. Kalis, E. J. Quattrocchi "Consensus Within Five Academic Subdivisions of Pharmacy: Progress Toward Establishing their Scientific Paradigms" Journal of Pharmacy Teaching, Volume 9, Number 2, 2002, pages 27-46.

S. P. Desselle, C. C. Collins, M. W. Harrold, M. M. Kalis, E. J. Quattrocchi "Quantitative and Qualitative Assessments of Consensus Within Pharmacy's Academic Subdivisions" Journal of Pharmacy Teaching, Volume 9, Number 4, 2002, pages 1-29.

Patent # 5408865 was granted on 4-25-95 to VanKel Industries entitled "Transdermal Cell Test Matter Volume-Adjustment Device", Inventors: Charles C. Collins, Pradeepkumar P. Sanghvi, Amy C. Little, Henry Hofer, and James E. Swon.

Significant Regional, State, or National Service:

  • Laboratory Special Interest Group, Section of Teachers of Pharmaceutics, American Association of Colleges of Pharmacy (AACP). Chairman for 2003 to 2004
  • Elected Delegate for BGCOP to annual AACP meeting in 2011
  • Over 50 research presentations at national meetings
  • Over 15 national and international invited presentations covering dissolution research and technology
  • Faculty Advisor (G.C.D.) to Kappa Psi Pharmaceutical Fraternity (a Co-Ed fraternity) – Duquesne, PBA, and BGCOP

Organizational Involvement/Membership:

Professional Society Memberships

  1. American Pharmacists Association (APhA) - Active member since 1977 - The national associations representing the interests of pharmacists.
  2. American Association of Pharmaceutical Scientists (AAPS) - Charter Member since 1986 - The premier national organization representing and promoting the sciences in pharmacy.
  3. American Association of Colleges of Pharmacy (AACP) - member since 1984 - The national organization concerned with pharmacy practice, pharmacy education policies and techniques.
  4. Controlled Release Society (CRS) - member 1988 to 2012 - Specialized organization focused on the controlled release of medicinal agents in agriculture, health, science and medicine.
  5. Christian Pharmacist Fellowship International (CPFI) – 2002 to 2005 and 2012 to present
  6. Tennessee Pharmacists Association (TPA) – 2006 to present

Personal motto or favorite quote:

"The secret of getting ahead is getting started." Mark Twain

"Love is patient, love is kind. It does not envy, it does not boast, it is not proud. It does not dishonor others, it is not self-seeking, it is not easily angered, it keeps no record of wrongs. Love does not delight in evil but rejoices with the truth. It always protects, always trusts, always hopes, always perseveres. Love never fails." 1 Corinthians 13, verses 4 to 8a

"We shall never know all the good that a simple smile can do." Mother Teresa

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