COPH Student, Alumnus, and Faculty Author Article in Diabetes Journal

Shaoqing Gong, Doctor of Public Health student in the Department of Biostatistics and Epidemiology, recently published an article titled as “Genetic association analysis of polymorphisms in PSD3 gene with obesity, type 2 diabetes, and HDL cholesterol” in Diabetes Research and Clinical Practice.

Kesheng Wang, Associate Professor, and Liang Wang, Assistant Professor in the Department of Biostatistics and Epidemiology, are co-authors.  Daniel Owusu, alumnus of the College of Public Health, is also a co-author.  Authors from other colleges and universities include Chun Xu of the University of Texas Rio Grande Valley, Beth Bailey of the Quillen College of Medicine, and Yujing Li of Emory University.

“Obesity has become a global epidemic and contributes to the increasing burden of type 2 diabetes, cardiovascular disease, osteoarthritis, respiratory disease, and a range of cancers, with global projections of more than 1.12 billion obese individuals by 2030,” commented Kesheng Wang.

Multiple logistic regression and linear regression models were used to examine the associations of 259 single nucleotide polymorphisms within the PSD3 gene with obesity and type 2 diabetes as binary traits, and high-density lipoprotein level as a continuous trait using the Marshfield data, respectively.

The present study is the first attempt to examine associations of the PSD3 gene with obesity, type 2 diabetes and high-density lipoprotein level. In total, 23 single nucleotide polymorphisms showed significant associations with obesity in the Marshfield sample. 6 single nucleotide polymorphisms associated with type 2 diabetes and 11 associated with high-density lipoprotein level.

“Patients with type 2 diabetes have decreased high-density lipoprotein cholesterol concentrations compared to those without type 2 diabetes,” continued Kesheng Wang.  “Findings offer new insights into the pathogenesis of obesity and diabetes.”

Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. Impact Factor of this Journal is 3.05 and 5-Year Impact Factor is 3.35.