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Biomedical Sciences

Quillen College of Medicine

Aaron Polichnowski
Aaron Polichnowski

Aaron  Polichnowski 

Assistant Professor
Biomedical Sciences



Additional Contact Information:

Department of Biomedical Sciences
Quillen College of Medicine
PO Box 70577
Johnson City, TN 37614
Carl A. Jones Hall (VA Bldg 1 & 119)
Office: VA Bldg. 1, Room 143
Lab: VA Bldg. 119, Rooms 320 & 322
Phone: 423-439-5625
Fax: 423-439-8044


Curriculum Vitae


1999 -  B.S., Exercise Science, East Tennessee State University
2001 -  M.S., Exercise Physiology, University of Wisconsin Milwaukee
2009 -  Ph.D., Physiology, Medical College of Wisconsin
2011 -  Postdoctoral Fellowship, Nephrology, Loyola University Chicago


  1. Acute kidney injury and chronic kidney disease.
  2. Reduced nitric oxide availability and susceptibility to hypertensive kidney disease.
  3. Regulation of renal blood flow.


Jacqueline Potter (Research Technician)


American Society of Nephrology (ASN) and the ASN Foundation for Kidney Research
Carl Gottschalk Research Scholar Grant
Role: Principle Investigator
7/01/2017 - 6/30/2019
Title: Deleterious effects of TNF-alpha on the AKI-CKD Nexus
These studies are designed to investigate the role of TNF-alpha in contributing to impaired recovery from AKI and the subsequent rapid progression of kidney disease in rats with preexisting CKD.

American Heart Association
Role: Principle Investigator
7/01/2017 - 6/30/2019
Title: The renal cholinergic system and the AKI-CKD nexus
These studies are designed to examine the interactions between the spleen and non-neuronal renal cholinergic cells in modulating recovery from AKI in mice.


  1. Picken MM, Long J, Williamson GA, Polichnowski AJ. Progression of Chronic Kidney Disease Following Acute Kidney Injury: Role of Self-perpetuating vs. Hemodynamic-induced Fibrosis. Hypertension 68(4):921-928, 2016.

  2. Polichnowski AJ, Licea-Vargas H, Picken MM, Long J, Bisla R, Williamson GA, Bidani AK, Griffin KA. Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy. Am J Physiol Renal Physiol. 309(9):F791-799, 2015.

  3. Griffin KA, Pothugunta K, Polichnowski AJ, Bidani AK. The role of systemic blood pressure in the progression of chronic kidney disease. Current Cardiovascular Risk Reports. May; 9(5), 2015.

  4. Polichnowski AJ, Griffin KA, Picken MM, Licea-Vargas H, Long J, Williamson GA, Bidani AK. Hemodynamic basis for the limited renal injury in rats with angiotensin II-induced hypertension. Am J Physiol Renal Physiol. 308(3):F252-260, 2015.

  5. Griffin KA, Polichnowski A, Litbarg N, Picken M, Venkatachalam MA, Bidani AK. The critical BP threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. Hypertension 64(4):801-807, 2014.

  6. Polichnowski AJ, Lan R, Geng H, Griffin KA, Venkatachalam MA, Bidani AK. Severe renal mass reduction impairs recovery and promotes fibrosis after AKI. J of Am Soc Nephrol. 25(7):1496-1507, 2014.

  7. Polichnowski AJ, Griffin KA, Long J, Williamson GW, Bidani AK. Blood pressure renal blood flow relationships in conscious angiotensin II- and phenylephrine-infused rats. Am J Physiol Renal Physiol. 305(7): 1074-1084, 2013.

  8. Bidani AK, Polichnowski AJ, Loutzenhiser R, Griffin KA. Renal microvascular dysfunction, hypertension and CKD progression. Curr Opin Nephrol Hypertens 22(1):1-9, 2013.

  9. Lan R, Geng H, Polichnowski AJ, Singha PK, Saikumar P, McEwen DG, Griffin KA, Koesters R, Weinberg JM, Bidani AK, Kriz W, Venkatachalam MA. PTEN loss defines a TGF induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis.
    Am J Physiol Renal Physiol 302(9): 1210-1223, 2012.

  10. Griffin K, Polichnowski A, Licea-Vargas H, Picken M, Long J, Williamson G, Bidani A. Large BP-dependent and independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers. Am J Physiol Renal Physiol 302(1): 173-182, 2012.

PubMed publications


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