Additional Contact Information:
Dr. Chad Frasier
Department of Biomedical Sciences
Quillen College of Medicine
East Tennessee State University
PO Box 70582
Johnson City, TN 37614
Stanton Gerber Bldg 178, B213 (office), B247 (Lab)
Office Phone: 423-439-2010
Ph.D. Department of Physiology, Brody School of Medicine, East Carolina University.
B.S. Central Michigan University (Neuroscience and Psychology).
2. Cardiac Arrhythmias
3. Cardiac Ischemia/Reperfusion Injury
The long-term plan for my laboratory is to determine how K+ channel remodeling and mitochondrial energetics affect cellular excitability, with the hope of uncovering novel therapeutic targets for human disease. Currently, there are three separate but related projects going on in my laboratory: 1) The relationship between cardiac potassium ion channels and the risk of sudden death in epilepsy models; 2) How voltage-gated sodium channel beta subunits interact with potassium channels in heart; and 3) Determine if cardiac cellular energetics are compromised in epilepsy models.
2018 Chad R. Frasier, Helen Zhang, James Offord, Louis T. Dang, David S. Auerbach, Huilin Shi, Chunling Chen, Alica M. Goldman, L. Lee Eckhardt, Vassilios J. Bezzerides, Jack M. Parent, and Lori L. Isom. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. (In Press) (PMID 30146492)
2017 Luis F. Lopez-Santiago, Yukun Yuan, Jacy L. Wagnon, Jacob Hull, Chad R. Frasier, Miriam H. Meisler, and Lori L. Isom. Neuronal Hyperexcitability in an SCN8A Mouse Model of Early Infantile Epileptic Encephalopathy with SUDEP. Proceedings of the National Academy of Sciences. 114(9): 2383-2388. (PMID 28193882)
2016 Chad R. Frasier, Jacy L. Wagnon, Yangyang Bao, Luis F. Lopez-Santiago, Miriam H. Meisler, and Lori L. Isom. Cardiac arrhythmia in a mouse model of Epileptic Encephalopathy with SUDEP. Proceedings of the National Academy of Sciences. (In Press). (PMID 27791149)
2014 Sarah M. Schumacher-Bass, Eileen D. Vesely, Lian Zhang, Katherine E. Ryland, Dyke P. McEwen, Priscilla J. Chan, Chad R. Frasier, Robin M. Shaw, and Jeffrey R. Martens. A role for Myosin V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circulation Research; 114(6):982-92. (PMID 24508725)
2013 Chad R. Frasier, Fatiha Moukdar, Hetal D. Patel, Ruben C. Sloan, Luke M. Stewart, Rick J. Alleman, Justin D. LaFavor, and David A. Brown. Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria. Cardiovascular Research; 98(1):47-55. (PMID 23341578)
2012 Robert A. Kloner, Sharon Hale, Wangde Dai, Robert C. Gorman, Takashi Shuto, Kevin J Koomalsingh, Joseph H. Gorman III, Ruben C. Sloan, Chad R. Frasier, Corinne A. Watson, Phillip A. Bostian, Alan P. Kypson, and David A. Brown. Reduction of Ischemia/Reperfusion injury with Bendavia, a mitochondrial-targeting cytoprotective peptide. Journal of the American Heart Association; 1 (3): e001644. (PMID 23130143)
2011 Ruben C. Sloan, Fatiha Moukdar, Chad R. Frasier, Phillip A. Bostian, and David A. Brown. A reductive shift in redox state attenuates ischemia/reperfusion injury, decreases sensitivity to calcium induced mitochondrial permeability transition and improves mitochondrial calcium handling in diabetic hearts. Journal of Molecular and Cellular Cardiology; 52(5):1009-18. (PMID 22406429)
2011 Chad R. Frasier, Ruben C. Sloan, Phillip A. Bostian, Michael Gonzon, Jennifer Kurowicki, Steven LoPresto, Ethan Anderson, and David A. Brown. Short-term exercise preserves myocardial glutathione and decreases arrhythmias following thiol oxidation and ischemia in isolated rat hearts. Journal of Applied Physiology; 111(6): 1751-1759. (PMID 21940849)
2011 Chad R. Frasier, Russell L. Moore, and David A. Brown. Exercise-induced cardiac preconditioning: How exercise can mend your achy breaky heart. Journal of Applied Physiology; 111(3): 905-915. (PMID 21393468)2010 David A. Brown, Miguel A. Aon, Chad R. Frasier, Ruben C. Sloan, Andrew H. Maloney, Ethan J. Anderson, and Brian O’Rourke. Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. Journal of Molecular and Cellular Cardiology; 48(4):673-679 (PMID 19962380).
PubMed link to publications