skip to main content columnskip to left navigationskip to horizontal navigation

Biomedical Sciences

Quillen College of Medicine

Tyrone Genade
Tyrone Genade

Tyrone  Genade 

Research Assistant Professor
Biomedical Sciences
Contact:

 

 

 

 

 

 

Additional Contact Information:

Department of Biomedical Sciences
James H. Quillen College of Medicine
PO Box 70582
Johnson City, TN 37614
Office: Stanton-Gerber Bldg 178, Room B025
Phone: 423-439-2048
Email: 


CURRICULUM VITAE

Curriculum Vitae

EDUCATION/PROFESSIONAL BACKGROUND

Ph.D. (Anatomy & Cell Biology) from the University of Cape Town

M.Sc. (Biochemistry) from the University of Stellenbosch

Dr. Genade trained as a biochemist, completing a M.Sc. studying the control of steroid biosynthesis using Control Analysis and computer modeling. After the completion of his M.Sc. he took up a research assistant position at the Neuroscience Institute in Pisa, Italy, studying neurodegeneration and aging of the new model organism, Nothobranchius furzeri. After working in Italy he returned to South Africa and started a Ph.D. in anatomy and cell biology. He then took up a post teaching anatomy and physiology at Northwestern College, Iowa before coming to the Quillen College of Medicine.

RESEARCH/TEACHING

  1. Neuroanatomy of aging
  2. Nothobranchius biology
  3. Anatomy teaching methods

    Nothobranchius fish are used as model of aging. They live short lives: Nothobranchius furzeri has a median lifespan of 12 to 40 week

    Genade fish pic

     

    During this short life it develops symptoms and pathologies of neurodegeneration, muscle wasting, tumors etc… Very little is know of its basic anatomy and biology. My lab focuses on determining the expression of proteins related to neuroanatomy and neuropathology in addition to running lifespan intervention studies (to extend lifespan) to determine which proteins change their expression and how this pertains to aging-related neuropathologies. Of particular interest are synucleins and DJ-1 (PARK7). Dr Genade also consults for, and performs experiments for, a pharmaceutical company testing compounds for anti-aging and anti-cancer effects.


    Genade Evidence figure

SELECTED PUBLICATIONS

Spaans & T. Genade (2017) Localization of alpha-synuclein protein in the central nervous system of the short-lived fish, Nothobranchius furzeri. Poster, Annual Neurobehavorial Research Symposium, University of South Dakota. http://dx.doi.org/10.13140/RG.2.2.24745.29283
D.A. Wilcox, M. MacDonald & T. Genade (2017) Nothobranchius furzeri displays evidence of alpha-synucleinopathy and possesses deleterious alleles of PARK7 in its genome. Poster, Annual Neurobehavorial Research Symposium, University of South Dakota. http://dx.doi.org/10.13140/RG.2.2.28874.67527
>T. Genade (2016). The Use of Kryptolebias marmoratus Eggs as an Educational Tool for Embryology Education. Bioscene: Journal of College Biology Teaching, 2016, 42(2):26--31. https://eric.ed.gov/?id=EJ1126346
T. Genade (2016) A low cost and adaptable benchtop recirculating aquarium system for Nothobranchius fish. Journal of the American Killifish Association, 49(1):2--13.
https://www.researchgate.net/publication/310088351_A_low_cost_and_adaptable_
benchtop_recirculating_aquarium_system_for_Nothobranchius_fish
}

icon for left menu icon for right menu