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Additional Contact Information: Department of Biomedical Sciences |
RESEARCH/TEACHING INTERESTS
NEUROPROTECTION AND NEUROGENESES AFTER SCI AND STROKE
The Hagg lab investigates how novel neurotrophic mechanisms and endogenous stemcell might be used to develop CNS repair strategies. We are currently identifying molecular signaling mechanisms and testing small molecules that activate neuroprotective mechanisms might be used to reduce tissue loss after an ischemic stroke injury. We focus on astroglial and endothelial/microvascular mechanisms that protect as well as those that lead to detrimental inflammation in the injured brain regions. Secondly we are identifying molecular regulators of endogenous neural precursors in adult rodents which can be targeted for enhancing neurogenesis and redirect neuroblast migration towards stroke injuries. The long term goal of these studies is to provide information that would lead to better treatment strageties for a variety of human neurological disorders, including spinal cord injury and stroke. Techniques used routinely include various refined microsurgical procedures in the brain and spinal cord of adult rats and mice, pharmacological treatments, regular and confocal immunohistochemistry, Western blotting and real-time PCR.
LABORATORY PERSONNEL
- Chiharu Lovins, MSc, Director of Research
- DEL Lovins, Technician
ACTIVE RESEARCH FUNDING
NIH R01AG029493 "Targeting CNTF to increase adult forebrain neurogenesis”
PUBMED
Complete List of PubMed Publications
SELECTED PUBLICATIONS
Jia C, Lovins C, Malone HM, Keasey MP, Hagg T (2022) Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition. J Cereb Blood Flow Metab. 2022 Oct;42(10):1961-1974. PMID: 35702047
Keasey MP, Lovins C, Jia C, Hagg T. (2022) Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice. Physiol Rep. 2022 May;10(9):e15301. PMID: 35531929
Jia C, Malone H, Keasey MP, Lovins C, Elam J, Hagg T (2020) Blood vitronectin induces detrimental brain IL-6 and correlates with outcomes after stroke only in female mice. Stroke 51(5):1587-1595. PMID 32312218, PMC7249257
Jia C, Keasey MP, Malone H, Lovins C, Sante RR, Razskazovskiy V, Hagg T (2019) Vitronectin from brain pericytes promotes adult forebrain neurogensis by stimulating CNTF. Experimental Neurology 312:20-32. PMID 30408465, PMC6326873.