NEUROPROTECTION AND NEUROGENESIS AFTER SCI AND STROKE
The Hagg lab investigates how novel neurotrophic mechanisms and endogenous stem cells
might be used to develop CNS repair strategies. We are currently investigating how
small molecules that activate neuroprotective mechanisms might be used to reduce axon
and myelin loss after a contusive spinal cord injury. We currently investigate how
endothelial and microvascular mechanisms could be utilized to reduce degeneration
after such injuries. Lastly, we are identifying molecular regulators of endogenous
neural precursors in adult rodents which can be targeted for enhancing neurogenesis
and redirect neuroblast migration towards stroke injuries. The long term goal of these
studies is to provide information that would lead to better treatment strategies for
a variety of human neurological disorders, including spinal cord injury and stroke.
Techniques used routinely include various refined microsurgical procedures in the
brain and spinal cord of adult rats and mice, pharmacological treatments, regular
and confocal immunohistochemistry, Western blotting and real-time PCR.
Matt P. Keasey, PhD, Research Assistant Professor
Chiharu Lovins, MSc, Director of Research
DEL Lovins, Technician
Hannah M. Malone, BSc, PhD Graduate Student
Cuihong Jia, PhD, collaborator, Assistant Professor
We are always looking for excellent people.
Come join us!
ACTIVE RESEARCH FUNDING
NIH R01AG029493 "Targeting CNTF to increase adult forebrain neurogenesis"
NIH R01NS102745 “Targeting blood-derived integrin signaling after stroke”
Jia C, Keasey MP, Malone H, Lovins C, Sante RR, Razskazovskiy V, Hagg T (2019) Vitronectin
from brain pericytes promotes adult forebrain neurogenesis by stimulating CNTF. Experimental
Neurology 312:20-32. PMID 30408465.
Jia C, Keasey MP, Malone H, Lovins C, Hagg T (2018) Inhibition of astrocyte FAK-JNK
signaling promotes subventricular zone neurogenesis through CNTF. Glia 66(11):2456-2469.
Jia C, Brown RW, Malone HM, Burgess KC, Gill WD, Keasey MP, Hagg T (2018) Ciliary
neurotrophic factor is a key sex-specific regulator of depressive-like behavior in
mice. Psychoneuroendocrinology 100:96-105. PMID: 30299260.
Keasey MP, Jia C, Pimentel LF, Sante RR, Lovins C, Hagg T. (2018) Blood vitronectin
is a major activator of LIF and IL-6 in the brain through integrin-FAK and uPAR signaling.
Journal of Cell Science Dec 8. pii: jcs.202580, PMID 29222114
Banerjee K, Keasey MP, Razskazovskiy V, Visavadiya NP, Jia C, Hagg T (2017) Reduced
FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and
death in endothelial cells. Cellular Signaling 36:154-162. PMID 28495589, PMC5589129.
Visavadiya NP, Keasey MP, Razskazovskiy V, Banerjee K, Jia C, Lovins C, Wright GL,
Hagg T. (2016) Integrin-FAK signaling rapidly and potently promotes mitochondrial
function through STAT3. Cell Communication and Signaling. 14(1):32. PMID 27978828,
Keasey MP, Lemos RR, Hagg T, Oliveira JRM (2016) Vitamin-D receptor agonist calcitriol
reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1
or XPR1. Scientific Reports 6:25802 PMID 27184385; PMC4868979
Ewan EE, Hagg T. (2016) Intrathecal Acetyl-l-Carnitine Protects Tissue and Improves
Function after a Mild Contusive Spinal Cord Injury in Rats. Journal of Neurotrauma 33(3):269-77.
Muradov JM, Ewan EE, Hagg T (2013) Dorsal column sensory axons degenerate due to impaired
microvascular perfusion after spinal cord injury in rats. Experimental Neurology
Keasey MP, Kang, SS, Lovins, C, Hagg T (2013) Inhibition of a novel specific neuroglial
integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Communication
and Signaling 11(1):35.
Kang SS, Keasey MP, Arnold SA, Reid R, Geralds JT, Hagg T (2012) Endogenous CNTF
mediates stroke-induced adult CNS neurogenesis in mice. Neurobiology of Disease 49:
Kang SS, Keasey MP, Cai J, Hagg T (2012) Loss of neuron-astrocyte interaction rapidly
induces protective CNTF expression after stroke in mice. Journal of Neuroscience 32:9277-87
Complete list of publications in PubMed: http://www.ncbi.nlm.nih.gov/pubmed/?term=Hagg+T