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Biomedical Sciences

Quillen College of Medicine

Richard Kostrzewa
Richard Kostrzewa

Richard  Kostrzewa 

Biomedical Sciences



Additional Contact Information:

Department of Biomedical Sciences
James H. Quillen College of Medicine
PO Box 70577
Johnson City, TN 37614


Curriculum Vitae


B.S. (Chemistry), M.S. (Pharmacology): Philadelphia College of Pharmacy & Science
Ph.D. (Pharmacology): University of Pennsylvania, Philadelphia PA
Dr. H.C : Medical University of Silesia, Katowice, Poland

Research Pharmacologist, Veterans Administration Medical Center, New Orleans, LA, 1971 75
Adjunct Asst. Prof., Pharmacology, Tulane University Medical Center, New Orleans, LA, 1974 76
Graduate Faculty, Department of Psychology, University of New Orleans, New Orleans, LA, 1974 77
Assistant Professor of Physiology, Louisiana State University Medical Center, New Orleans, LA, 1975 78
Professor of Pharmacology/Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, 1984 present; Associate Professor, 1978 84
Visiting Professor, Medical University of Silesia in Katowice, Poland, 1997-2003


  • Dopamine receptor supersensitivity
  • Dopamine systems relating to ADHD, Parkinson Disease, Tardive Dyskinesia
  • Highly selective neurotoxins


Nowak P, Noras, J Jochem, R Szkilnik, H Brus, E Korossy, J Drab, RM Kostrzewa, R Brus (2009) Histaminergic activity in a rodent model of Parkinsons disease. Neurotoxicity Res. 15(3), 246-251. doi: 10.1007/s12640-009-9025-1. Epub 2009 Feb 28.

Kostrzewa RM(2009) Evolution of neurotoxins: from research modalities to clinical realities, In Curent. Protocols in Neuroscience, Wiley Interscience. Chapter 1:Unit1.18, pp. 1.18.1-1.18.10.

Kostrzewa RM, RA Kostrzewa, JP Kostrzewa (2009) Botulinum toxin for restoration of bladder control. The Female Patient 34, 20-23.

Kostrzewa RM (2009) Editorial on Neurotoxicity. Neurotoxicity Res. 15(1), 1-2. DOI: 10.1007/s12640-009-9029-x.

Nowak P, D Nitka, A Kwieciski, J Joko, J Drab, D Pojda-Wilczek, J Kasperski, RM Kostrzewa, R Brus (2009) Neonatal co-lesion by DSP-4 and 5,7-DHT produces adulthood behavioral sensitization to dopamine D2 receptor agonists. Pharmacol. Rep. 61, 311-318.

Kostrzewa RM (2010) Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment, In: 5-HT2C Receptors in the Pathophysiology of CNS Disease (Di Giovanni G, E Esposito, V Di Matteo, Eds.) (Humana Press/Springer Science+Business Media, New York), pp. 383-393. ISBN: 978-1-60761-940-6. DOI: 10.1007/9780-1-60761-941-3.

Nowak P, RA Kostrzewa, D Skaba, RM Kostrzewa (2010) Acute L-DOPA effect on hydroxyl radical- and DOPAC-levels in striatal microdialysates of Parkinsonian rats. Neurotoxicity Res. 17(3), 299-304. DOI: 10.1007/s12640-009-9105-2. Epub, Sept. 4, 2009.

Archer T, RM Kostrzewa (2010) Staging neurological disorders: expressions of cognitive and motor disorder. Neurotoxicity Res. 18(2), 107-111. DOI 10.1007/s12640-009-9134-x. [Editorial] Epub Nov 26, 2009.

Archer T, RM Kostrzewa, T Palomo, RJ Beninger (2010) Clinical staging in the pathophysiology of psychotic and affective disorders: facilitation of prognosis and treatment. Neurotoxicity Res. 18(3-4), 211-228. Epub 2010 Mar 17.

Kostrzewa RM, L Antkiewicz-Michaluk, F Fornai (2010) Dopaminergic nerves as targets for neurotoxins, In: Neurotoxicology, Target Organ Toxicity Series, 3rd Edition (Harry J, H Tilson, Eds.), Informa Health Care, New York, pp. 112-137. [ISBN: 9781420054873]

Archer T, RM Kostrzewa, RJ Beninger, T Palomo (2010) Staging perspectives in neurodevelopmental aspects of neuropsychiatry: agents, phases and ages at expression. Neurotoxicity Res. 18(3-4), 287-305. Epub 2010 Mar 17. 

Archer T, RJ Beninger, T Palomo, RM Kostrzewa (2010) Epigenetics and biomarkers in the staging of neuropsychiatric disorders. Neurotoxicity Res. 18(3-4), 347-366. Epub 2010 Mar 17.

Ferdyn-Drosik M, P Nowak, K Bojanek, M Baasz, J Kasperski, D Skaba, R Muchacki, RM Kostrzewa (2010) Neonatal DSP-4 treatment impairs 5-HT1B receptor reactivity in adult rats. Behavioral and biochemical studies. Pharmacol. Rep. 62(4), 608-20. PMID: 20885001.

Kostrzewa RM, JP Kostrzewa, RA Kostrzewa, FP Kostrzewa, R Brus, P Nowak (2011) Stereotypic progressions in psychotic behavior. Neurotoxicity Res. 19, 243-252. DOI: 10.1007/s12640-010-9192-0

Nowak P, K Bojanek, R Szkilnik, J Joko, D Boron, M Adwent, P Gorczyca, RM Kostrzewa, R Brus (2011) Ontogenetic exposure of rats to pre- and postnatal manganese enhances behavioral impairments produced by perinatal 6-hydroxydopamine. Neurotoxicity Res. 19(4), 536-543. Epub 2010 Apr 6. PMID: 20369314. DOI: 10.1007/s126.

Archer T, RM Kostrzewa, RJ Beninger, T Palomo (2011) Staging neurodegenerative disorders: structural, regional, biomarker and functional progressions. Neurotoxicity Res. 19, 211-234.

Joko J, J Drab, P Nowak R Szkilnik, E Krssy, D Boro, H Brus, RM Kostrzewa, R Brus (2011) Thioperamide, an H3 receptor antagonist, prevents [3H]glucose uptake in adult rats lesioned as neonates with 5,7-dihydroxytryptamine. Neurotoxicity Res. 20(1), 93-96. Epub 2010 Sep 14. PMID: 20838953

Joko J, J Drab, J Jochem, P Nowak, R Szkilnik, E Krssy-Mruk, D Boro, RM Kostrzewa, H Brus, R Brus (2011) Ontogenetic serotoninergic lesioning alters histaminergic activity in rats in adulthood. Neurotoxicity Res. 20(2), 103-108. Epub 2010 Sep 14. PMID: 20838952. DOI: 10.1007/s12640-010-9217-8.

Archer T, A Fredriksson, E Szhulz, RM Kostrzewa (2011) Influence of physical exercise on neuroimmunological functioning and health: aging and stress. Neurotoxicity Res. 20(1), 69-83. Epub 2010 Oct 15. DOI: 10.1007/s12640.010-9224-9. PMID: 20953749.

Brus R, J Jochem, P Nowak, M Adwent, D Boro, H Brus, RM Kostrzewa (2012) Effect of pre- and postnatal manganese exposure on brain histamine content in a rodent model of Parkinsons disease. Neurotoxicity Res. 21(2), 143-148. Epub 2011 Aug 6. PMID: 21822760.

Archer T, RM Kostrzewa (2012) Physical exercise alleviates ADHD symptoms: regional deficits and development trajectory. Neurotoxicity Res. 21(2), 195-209. Epub 2011 Aug 18. PMID: 21850535.

Kostrzewa RM, FP Kostrzewa (2012) Neonatal 6-hydroxydopamine lesioning enhances quinpirole-induced vertical jumping in rats that were quinpirole-primed during postnatal ontogeny. Neurotoxicity Res. 21(2):231-235. Epub 2011 Aug 19. DOI: 10.1007/s12640-011-9268-5. PMID: 21853388.

Labus , P Nowak, R Szkilnik, RM Kostrzewa, D Boro, R Brus (2012) Neonatal DSP-4 lesioning of central noradrenergic neurons: a model for the study of interaction with other neurotransmitter systems in the brain of adult rats. Annales Acad. Med. Silesiensis.

Brown RW, AM Maple, MK Perna, AB Sheppard, ZA Cope, RM Kostrzewa (2012) Schizophrenia and substance abuse comorbidity: Nicotine addiction and the neonatal quinpirole model. Review. Dev Neurosci. 34(2-3), 140-151. Epub 2012 Jul 6.

Korossy-Mruk E, K Kuter, P Nowak, R Szkilnik, RM Kostrzewa, R Brus (2013) Neonatal DSP-4 treatment modifies analgesic effect of methanandamide, a CB1 receptor agonist in adult rats. Neurotoxicity Res. 23(1), 39-48.

Archer T, RM Kostrzewa (2013) The inductive agency of stress: from perinatal to adolescent induction, In Adaptive and Maladaptive Aspects of Developmental Stress, (Laviola G, S Macri, Eds.),. Springer New York, pp. 1-20.

Nowak P, M Kowaliska-Kania, D Nowak, RM Kostrzewa, J Malinowska-Borowska (2013) Antinociceptive effects of H3 (R-methylhistamine) and GABAB (baclofen) -receptor ligands in an orofacial model of pain in rats. Neurotoxicity Res. 24, 258-264. Epub 2013 Mar 6. Doi: 10.1007/s12640-013-9385-4. PMID: 23463522.

Kostrzewa RM, JP Kostrzewa, R Brus (2014) Tardive dyskinesia: Outcome of antipsychotic treatment and brain damage?, in Section on Diseases and Disorders Relevant to Neurotoxins, in Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_163.

Kostrzewa RM (2014) Survey of Selective Neurotoxins (chapter title), in Section on Selective Neurotoxins, in Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, Heidelberg, Dordrecht, London, 2014, pp. 3-67. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_53.

Archer T, S Ricci, M Rapp-Ricciardi, RM Kostrzewa (2014) Polluting agents in Parkinsonism: I Transition metals, in Section on Neurotoxicity in Psychiatric and Neurologic Disorders, in Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle).

Chen J, RM Kostrzewa, X Xu (2014) Necroptosis, a potential therapeutic target for neurological disorders, in Section on Selective Neurotoxins (RM Kostrzewa, Section Editor), in Handbook of Neurotoxicity (Kostrzewa RM, Editor), Springer New York, pp. 2315-2326. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4_166.

Szkilnik R, R Brus, J Malinowska-Borowska, D Nowak, M Waliczek, RM Kostrzewa, P Nowak (2014) Ontogenetic manganese exposure with perinatal 6-OHDA lesioning alters behavioral responses of rats to dopamine D1 and D2 agonist treatments. Environ. Toxicol. Pharmacol. 37, 28-36.

Chandley MJ, A Szebeni, K Szebeni, JD Crawford, CA Stockmeier, G Turecki, RM Kostrzewa, GA Ordway (2014) Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression. Int. J. Neuropsychopharmacol. pp 1-10. doi:10.1017/S1461145714000662

Baasz M, R Szkilnik, R Brus, J Malinowska-Borowska, D Nowak, RM Kostrzewa, P Nowak (2015) Perinatal manganese exposure and hydroxyl radical formation in rat brain. Neurotoxicity Res. 27, 1-14.

Danysz W, G Fink, A McCreary, C Tober, W Dimpfel, JC Bizot, RM Kostrzewa, RW Brown, CC Jatzke, S Greco, AK Jensen, CG Parsons (2015) Effects of sarizotan in animal models of ADHD challenging pharmacokinetic-pharmacodynamic relationships. J. Neural Transm. (in press) DOI 10.1007/s00702-015-1392-6

Sadakierska-Chudy A, RM Kostrzewa, M Filip (2015) A comprehensive view of the epigenetic landscape. Part I. DNA methylation, passive and active DNA demethylation pathways and histone variants. Neurotoxicity Res. 27, 84-97.

Segura-Aguilar J, RM Kostrzewa (2015) Neurotoxin mechanisms and processes relevant to Parkinsons Disease. An update. Neurotoxicity Res. 27, 328-354.

Li X, Zhao H, Tan X, Kostrzewa RM, Du G, Chen Y, Zhu J, Miao Z, Yu H, Kong J, Xu X (2015) Inhibition of connexin43 improves functional recovery after ischemic brain injury in neonatal rats. Glia 2015 May 19. doi: 10.1002/glia.22826. [Epub ahead of print]


Palomo T, RJ Beninger, RM Kostrzewa and T Archer (co-Editors), 708 pages, Beyond Neuropsychiatric Diagnostics: Symptoms not Disorders, Fundacin Cerebro y Mente, Madrid, Spain, 2009. ISBN 978-84-934250-4-3

Palomo T, RM Kostrzewa and RJ Beninger (co-Editors), 433 pages, Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment, Fundacin Cerebro y Mente, Madrid, Spain, 2013. ISBN 978-1-4614-7263-6

Kostrzewa RM (Editor-in-Chief) Handbook of Neurotoxicity, Springer New York, Heidelberg, Dordrecht, London, June 2014. ISBN 978-1-4614-5835-7 (print); ISBN 978-1-4614-5836-4 (eBook); ISBN 978-1-4614-7458-6 (print and electronic bundle). DOI 10.1007/978-1-4614-5836-4



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