2001- B.S. - University of Wisconsin-Madison (Psychology)
2009- M.S.- University of Wisconsin-Madison (Psychology)
2012-Ph.D.- University of Wisconsin-Madison (Psychology [Biology of Brain and Behavior])
2012-2014- Post doctoral Training- The Scripps Research Institute, La Jolla, CA
2014-2019- Post doctoral Training- The National Institute on Drug Abuse, Intramural
Research Program, Baltimore, MD
1. Neurobiology/neurocircuitry of substance/alcohol use disorders
2. Neuropeptide contributions to compulsive drug/alcohol intake
3. Sleep dysfunction comorbidity in substance/alcohol use disorders
Research interests in our laboratory center around the neurobiology and neurocircuitry
underyling addiction and related comorbidities. Our studies primarily focus on the
role of negative reinforcement in the motivation to excessively seek and take drugs
of abuse (including psychostimulants and opioids) and/or alcohol. We largely use an
extended access to drug/alcohol self-administration paradigm as an animal model of
drug and alcohol addiction that mimics the transition from recreational use to excessive,
compulsive use associated with dependence in humans. In conjunction with other multidisciplinary
techniques, this dependence model allows us to examine the neurobiological mechanisms
that underlie compulsive behavior patterns of addiction and sleep alterations associated
with dependence and withdrawal. Our addiction research focuses on the contributions
of stress system sensitization, reward deficits, and sleep dysfunction to various
states of dependence, including withdrawal and relapse. Current neurotransmitter/peptides
of interest include hypocretin/orexin, dynorphin, and norepinephrine. Our ultimate
goal is to identify potential neurobiological targets for the pharmacological treatment
of substance use disorders that can be used in combination with behavioral therapies
in the clinical setting.
Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Sharhryari R, Kieffer BL, Koob GF,
Martin-Fardon R, Contet C (2018). Knockdown of hypocretin attenuates extended access
cocaine self-administration in rats. Neuropyschopharmacology 43: 2373-2382.
Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta E, Cole M, George O, Vandewater S, Taffe M, Koob GF, Vendruscolo LF
(2018). Compulsive-like sufentanil vapor self-administration in rats. Neuropsychopharmacology 43(4):801-809.
Schmeichel BE, Herman MA, Roberto M, and Koob GF (2017). Hypocretin Neurotransmission within the
Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-induced
Reinstatement in Rats. Biological Psychiatry 81(7): 606-615.
Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson
C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF (2015). Hypocretin receptor 2 antagonism
dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology 40: 1123-1129.
Schmeichel BE and Berridge CW (2014). Amphetamine acts within the lateral hypothalamic area to
elicit affectively neutral arousal and reinstate drug seeking. International Journal of Neuropsychopharmacology 17: 63-75.
Schmeichel BE and Berridge CW (2013). Neurocircuitry underlying the preferential sensitivity of
prefrontal catecholamines to low-dose psychostimulants. Neuropsychopharmacology 38: 1078-1084.
Schmeichel BE and Berridge CW (2013). Wake-promoting actions of noradrenergic α1- and β-receptors
within the lateral hypothalamic area. European Journal of Neuroscience 37: 891-900.