Research/Teaching Interests:
My laboratory focuses on elucidating the mechanisms of leukocyte migration during acute and chronic inflammation.
A major area of interest is the family of cell-surface receptors, integrins, which mediate interactions with extracellular ligands and transduce signals to the cytoskeleton, thereby regulating cell adhesion, migration, and intracellular signaling under both physiological and pathological conditions. In particular, we study the roles of the β2 integrins - αDβ2 and αMβ2 in macrophages and neutrophils during the development of acute inflammatory responses, such as sepsis, and chronic inflammatory diseases, including atherosclerosis.