Welcome to the Center of Excellence in Inflammation, Infectious Disease & Immunity where innovative research is vital to medical breakthroughs!
At the COE in Inflammation, Infectious Disease and Immunity, human subjects research is our backbone. Together with other experienced members, CIIDI explores opportunities for collaborative advancements in human immunology & disease and apply those efforts towards improving the quality of patient care. From workbench to bedside, our researchers are among the best in their field.
THE CLINICAL RESEARCH OFFICE
With CIIDI’s influx of recruitment rates, sample acquisition, and additional large-scale collaborative efforts, it was imperative to create a formal Clinical Research Office.
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Emerging Topics Series: The UTHSC 100K Genomes Project

Dr. Robert Davis, MD, MPH is the founding director of the UTHSC Center for Biomedical Informatics and the University of Tennessee-Oak Ridge National Laboratory Governor’s Chair in Biomedical Informatics, and a Professor in the UTHSC Department of Pediatrics.
Dr. Davis will present, as part of CIIDI's emerging topics series: The UTHSC 100K Genomes Project.
"Progress in genomic medicine threatens to leave behind medically underserved communities, including the predominantly african american population in west Tennessee as well as the Appalachian population in east Tennessee. This talk will focus on the UTHSC 100K Genomes Project, which is a statewide initiative to study how genomic variants affect health and disease. We currently have over32,000 subjects enrolled along with exome sequence and SNP data, linked to electronic medical record dat, on over 13,000. I will revieew studiess that are currently underwayin asthma, epilepsy, and cardiomyopathyand would welcome a discussion of how ETSU researchers might participate and lead studiesin their own fields of interest."
For individuals who wish to attend via Zoom, please register using this link:
For individuals who wish to learn more about the BIG project, click here:
Dr. Mark Kleinman is Corresponding Author on Article in International Journal of Molecular Sciences

Dr. Kleinman, MD states, "Our data suggests that the Rosa26-Cas9 knock-in mouse is an excellent model system for genetic manipulation in the RPE/choroid and neural retina using CRISPR tools."
The complete article can be found by clicking here: