Dr. Frasier

Education and Training

Central Michigan University, 2007
Neuroscience and Psychology (Double Major)

East Carolina University, 2012
Brody School of Medicine
Physiology

University of Michigan, 2018
Michigan Medicine
Department of Pharmacology
Publications

For the most up to date list of my published work visit MyBibliography: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/40233727/?sort=date&direction=ascending

2020 May Wingard, Chad R. Frasier, Mahipal Singh, Krishna Singh. Heart Failure and Diabtes: Role of ATM. Current Opinion in Pharmacology. (PMID 32745970)

2018 Chad R. Frasier, Helen Zhang, James Offord, Louis T. Dang, David S. Auerbach, Huilin Shi, Chunling Chen, Alica M. Goldman, L. Lee Eckhardt, Vassilios J. Bezzerides, Jack M. Parent, and Lori L. Isom. Channelopathy as a SUDEP Biomarker in Dravet Syndrome Patient-Derived Cardiac Myocytes. Stem Cell Reports. (In Press) (PMID 30146492)

2017 Nathan A. Holland, Chad R. Frasier, Ruben C. Sloan III, Robert B. Devlin, David A. Brown and Christopher J. Wingard. Ultrafine Particulate Matter Increases Cardiac Ischemia/Reperfusion Injury via Mitochondrial Permeability Transition Pore. Cardiovascular Toxicology. 17(4):441-450. (PMID 28194639)

2017 Luis F. Lopez-Santiago, Yukun Yuan, Jacy L. Wagnon, Jacob Hull, Chad R. Frasier, Miriam H. Meisler, and Lori L. Isom. Neuronal Hyperexcitability in an SCN8A Mouse Model of Early Infantile Epileptic Encephalopathy with SUDEP. Proceedings of the National Academy of Sciences. 114(9): 2383-2388. (PMID 28193882)

2016 Yangyang Bao, B. Cicero Willis, Chad R. Frasier, Xianming Lin, Roberto Mondragon Ramos, Héctor H. Valdivia, Mario Delmar, José Jalife, Lori L. Isom. Deletion of Voltage-gated Sodium Channel B2 Subunits in Mice Results in Brugada Syndrome-like Phenotype. Circulation Arrhythmia and Electrophysiology. 9(12). (PMID 27932425)

2016 Chad R. Frasier, Jacy L. Wagnon, Yangyang Bao, Luis F. Lopez-Santiago, Miriam H. Meisler, and Lori L. Isom. Cardiac arrhythmia in a mouse model of Epileptic Encephalopathy with SUDEP. Proceedings of the National Academy of Sciences. (In Press). (PMID 27791149)

2014 Sarah M. Schumacher-Bass, Eileen D. Vesely, Lian Zhang, Katherine E. Ryland, Dyke P. McEwen, Priscilla J. Chan, Chad R. Frasier, Robin M. Shaw, and Jeffrey R. Martens. A role for Myosin V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circulation Research; 114(6):982-92. (PMID 24508725)

2013 David A. Brown, Sharon Hale, Christopher Baines, Carlos del Rio, Robert Hamlin, Yukie Yueyama, Anusak Kijtawornrat, Steve Yeh, Chad R. Frasier, Luke Stewart, Saame Raza Shaikh, Kelsey Fisher-Wellman, Peter Darrell Neufer, and Robert Kloner. Reduction of early reperfusion injury with the mitochondria-targeting peptide Bendavia: A multicenter study. Journal of Cardiovascular Pharmacology and Therapeutics; 19 (1):121-32 . (PMID 24288396)

2013 Chad R. Frasier, David A. Brown, Ruben C. Sloan, Brian Hayes, Luke M. Stewart, Robert M. Lust, and Matthew D. Rosenbaum. Estrous cycle stage does not influence myocardial ischemia reperfusion injury in the rat (Rattus norvegicus): Insight from in vivo and ex vivo experimental models. Comparative Medicine 63 (5): 416-421. (PMID 24210018)

2013 Chad R. Frasier, Fatiha Moukdar, Hetal D. Patel, Ruben C. Sloan, Luke M. Stewart, Rick J. Alleman, Justin D. LaFavor, and David A. Brown. Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria. Cardiovascular Research; 98(1):47-55. (PMID 23341578)

2012 Leslie C. Thompson, Chad R. Frasier, Ruben C. Sloan, Erin E. Mann, Ben Harrison, David A. Brown, Jared M. Brown, and Christopher J. Wingard. Pulmonary Exposure to Multi-Walled Carbon Nanotubes Alters Cardiovascular Function that Promotes Ischemia/Reperfusion Injury in a Langendorff Heart Model. Nanotoxicology 8 (1):38-49. (PMID 23102262)

2012 Robert A. Kloner, Sharon Hale, Wangde Dai, Robert C. Gorman, Takashi Shuto, Kevin J Koomalsingh, Joseph H. Gorman III, Ruben C. Sloan, Chad R. Frasier, Corinne A. Watson, Phillip A. Bostian, Alan P. Kypson, and David A. Brown. Reduction of Ischemia/Reperfusion injury with Bendavia, a mitochondrial-targeting cytoprotective peptide. Journal of the American Heart Association; 1 (3): e001644. (PMID 23130143)

2011 Ruben C. Sloan, Fatiha Moukdar, Chad R. Frasier, Phillip A. Bostian, and David A. Brown. Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. Journal of Molecular and Cellular Cardiology; 52(5):1009-18. (PMID 22406429)

2011 Chad R. Frasier, Ruben C. Sloan, Phillip A. Bostian, Michael Gonzon, Jennifer Kurowicki, Steven LoPresto, Ethan Anderson, and David A. Brown. Short-term exercise preserves myocardial glutathione and decreases arrhythmias following thiol oxidation and ischemia in isolated rat hearts. Journal of Applied Physiology; 111(6): 1751-1759. (PMID 21940849)

2011 Chad R. Frasier, Russell L. Moore, and David A. Brown. Exercise-induced cardiac preconditioning: How exercise can mend your achy breaky heart. Journal of Applied Physiology; 111(3): 905-915. (PMID 21393468)

2010 Ruben C. Sloan, Matthew Rosenbaum, Dorcas O’Rourke, Karen Oppelt, Chad R. Frasier, Corinne A. Waston, Amanda G. Allan, and David A. Brown. Ketamine/xylazine anesthesia influences cardiac ischemia-reperfusion injury in guinea pigs in a dose-dependent manner. Journal of the American Association for Laboratory Animal Science; 50(3): 349-354 (PMID 21640030).

2010 David A. Brown, Miguel A. Aon, Chad R. Frasier, Ruben C. Sloan, Andrew H. Maloney, Ethan J. Anderson, and Brian O’Rourke. Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization. Journal of Molecular and Cellular Cardiology; 48(4):673-679 (PMID 19962380).
Funding

NINDS R21 1R21NS116647-01A1
Project Title: “The role of cardiac mitochondrial energetics in cardiac arrhythmias and SUDEP”
2020-2022

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