Recent Publications and Presentations
Selected publications 2010-2011.
Parti R.P., Loper R., Brown G.D., Gordon S., Taylor P.R., Bonventre J.V., Murphy R.C., Williams D.L., Leslie C.C. Cytosolic Phospholipase A2 Activation by Candida albicans in Alveolar Macrophages: Role of Dectin-1. Am J Respir Cell Mol Biol . 42(4):415-23, 2010.
Ha, T., Lu, C., Liu, L., Hau, F., Hu., Y., Kelley, J., Singh, K., Kao, R.L., Kalbfleisch, J. Williams, D.L., Gao, X. and Li, C. TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase dependent mechanism. Am. J. Physiol. Heart Circ. Physiol. 298:H984-H991, 2010.
Lu, C., Hua, F., Liu, L., Ha, T. Kalbfleisch, J., Schweitzer, J., Kelley, J., Kao, R., Williams, D., Li, C. The macrophage scavenger receptor-A plays a central role in focal cerebral ischemia/reperfusion injury. Journal of Cerebral Blood Flow and Metabolism 30:1972-1981, 2010.
Ha, T., Hu, Y., Liu, L, Lu, C., McMullen, J.R., Kelley, J., Kao, R.L., Williams, D.L., Gao, X. and Li, C. TLR2 ligands induce cardioprotection against ischemia/reperfusion injury through a PI3K/Akt-dependent mechanism. Cardiovascular Research 87(4):694-703, 2010.
Wondergem, R., Graves, B.M., Ozment-Skelton, T.R., Li, C., Williams, D.L. Lipopolysaccharides directly decrease Ca 2+ oscillations and the hyperpolarization-activated non-selective cation current lf in immortalized HL-1 cardiomyocytes. Am. J. Physiol. Cell. Physiol. 299(3):C665-71, 2010.
Suram, S., Gangelhoff, T.A., Taylor, P.R., Rosas, M., Brown, G.D., Bonventre, J.V., Akira, S., Uematsu, S., Williams, D.L., Murphy, R.C. and Leslie, C.C. Pathways regulating cytosolic phospholipase A 2 activation and eicosanoid production in macrophages by Candida albicans. J. Biol. Chem. 285(40):30676-85 , 2010.
Gazi, U., Rosas, M., Singh, S., Heinsbroek, S., Haq, I., Johnson, S., Brown, G.D., Williams, D.L., Taylor, P.R., Martinez-Pomares, L., Fungal recognition enhances mannose receptor shedding through dectin-1 engagement. J. Biol. Chem. 286(10):7822-9 , 2011.
Kruppa, M., Greene, R.R., Noss, I., Lowman, D.W., Williams, D.L. C. albicans increases cell wall mannoprotein, but not mannan, in response to blood, serum and cultivation at physiological temperature. G lycobiology Advance Access April 21, 2011.
Ha, T., Xia, Y., Liu, X., Lu, C., Liu, L., Kelley, J., Kalbfleisch, J., Kao, R.L., Williams, D.L. Li, C. Glucan phosphate attenuates myocardial HMGB-1 translocation in severe sepsis through inhibiting NF-B activation. Am. J. Physiol. Heart Circ. Physiol. [Epub ahead of print] June 3, 2011.
Smeekens, S.P., van de Veerdonk, F.L., Joosten, L.A.B., Jacobs, L., Jansen, T., Williams, D.L., van der Meer, J.W.M., Kullberg, B.J., Netea, M.G. The classical CD14 ++CD16 - monocytes, but not the patrolling CD14 +CD16 + monocytes, promote Th17 responses to Candida albicans . Eur. J. Immunol. [Epub ahead of print] June 22, 2011.
Lu, C., Liu, L., Chen,Y., Ha.,T., Kelley, J., Schweitzer,J., Kalbfleisch,J., Kao,R.L., Williams,D.L., Li, C. TLR2 ligand induces protection against cerebral ischemia/reperfusion injury: via activation of PI3k/Akt signaling. J. Immunol. [Epub ahead of print] June 27, 2011.
Selected presentations 2010-2011
Ozment-Skelton, T., Kruppa, M., Ha, T., Li, C., Breuel, K., Kalbfleisch, J., Williams. D. Caveolin-1 promotes survival in Candida albicans sepsis by modulating Dectin-1 expression and signaling. Trauma, Sepsis, Inflammation and Shock 2010, Munich, Germany.
Williams, D., Ozment-Skelton, T., Steagald, M., Graves, B., Dunn, J., Gambrell, D., Kalbfleisch, J., Breuel, K., Ford, T., Li, C., Browder, W. Aging decreases human leukocyte Dectin-1 responsiveness and co-operativity with TLR2. Trauma, Sepsis, Inflammation and Shock 2010, Munich, Germany.
Ha, T., Liu, X., Lu, C., Kelley, J., Kalbfleisch, J., Kao, R.L., Williams, D.L. and Li, C. Glucan phosphate decreases HMGB-1 translocation in the myocardium of septic mice via inhibition of NF k B activation. 33 rd Annual Shock Society Conference, Portland, OR, 2010.
Wondergem, R., Graves, B., Ozment-Skelton, T., Li, C. and Williams, D. Lipopolysaccharide directly inhibits calcium oscillations and the hyperpolarization-activated, non-selective cation current I f in HL-1 cardiomyocytes. 33 rd Annual Shock Society Conference, Portland, OR, 2010.
Lu, C., Liu, L., Ha, T., Kelley, J., Kao, R., Williams, D. and Li, C. TLR9 ligand induces protection against cerebral ischemia/reperfusion injury via a PI3K/Akt dependent mechanism. AHA Scientific Sessions 2010.
Cao, Z., Hu, Y., Ha., T., Kelley, J., Kao, R., Williams, D., Liu, L., and Li, C. TLR9 ligand induces protection against myocardial ischemia/reperfusion injury via a PI3K/Akt dependent mechanism. AHA Scientific Sessions 2010.
Zhang, X., Ha., T., Kelley, J., Kao, R., Williams, D. and Li, C. TLR3 ligand attenuates cerebral ischemia/reperfusion injury. International Stroke Conference 2011.
Yu, H., Wang, X., Kelley, J., Kao, R., Williams, D. and Li, C. The macrophage class A scavenger receptor (SR-A) co-operates with TLR4 in response to LPS stimulation. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Gao, M., Zhang, X., Ha, T., Wang, X., Kelley, J., Singh, K., Kao, R., Williams, D. and Li, C. TLR3 deficiency attenuates cardiac dysfunction in septic mice. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Zhang, X., Gao, M., Yu, H., Lu, C., Ha., T., Williams, D. and Li, C. Toll-like receptor 9 in trauma-hemorrhage. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Hoover, D.B., Ozment-Skelton, T.R., Wondergem, R., Li, C. and Williams, D. Decreased heart rate and prolongation of the QTc interval in septic mice. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Wondergem, R., Graves, B., Li, C. and Williams, D. Lipopolysaccharide directly inhibits rapid delayed rectifier K+ current, I kr , and calcium oscillations in HL-1 cardiomyocytes. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Graves, B.M., Wondergem, R., Simerly, T., Li, C. and Williams, D. Inhibition of phosphoinositide-3-kinase (PI3k)/Akt dependent signaling inhibits [Ca 2+] I oscillations in the HL-1 cardiomyocytes. 34 th Annual Conference on Shock, Norfolk, VA, 2011.
Ozment-Skelton, T.R., Ha, T., Li, C. and Williams, D. SR-A interacts with TLR4 to induce inflammation and inhibit bacterial clearance in polymicrobial sepsis. 34 th Annual Conference on Shock, Norfolk, VA, 2011.