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Scholarship in the Division of Endocrinology
The Endocrinology Division is active in both clinical research and basic molecular mechanisms of disease. The NIH NIDDK has supported studies of exercise training as a preventative measure in persons at high risk for type 2 diabetes. Participant is the research endeavors of the Division include residents in Internal Medicine and graduate students in Biomedical Sciences, Exercise Science, and Nutrition. Undergraduate students and pre-doctoral medical students are regularly involved in these projects. The research focus of the Endocrine faculty is on insulin resistance and diabetes prevention.
Recent publications include:
Stuart CA, Howell MEA, Zhang Y, Yin D. Insulin-Stimulated Translocation Of GLUT12 Parallels That of GLUT4 In Normal Muscle. J Clin Endocrinol Metab 94:3535-3542, 2009.
Stuart CA, Howell MEA, Baker JD, Dykes RJ, Duffourc MM, Ramsey MW, Stone MH. Cycle Training Increased GLUT4 and Activation of mTOR in Fast Twitch Muscle Fibers. Medicine and Science in Sports and Exercise 42: 96-106, 2010.
Layne AS, Nasrallah S, South MA, Howell MEA, McCurry MP, Ramsey MW, Stone MH, Stuart CA: Impaired Muscle AMPK Activation In The Metabolic Syndrome May Attenuate Improved Insulin Action After Exercise Training. J Clin Endocrinol Metab 96:1815-1826, 2011.
Stuart CA, Ross IR, Howell MEA, McCurry MP, Wood TG, Ceci JD, Kennel SJ, Wall J: Brain Glucose Transporter (Glut3) Haploinsufficiency Does Not Impair Mouse Brain Glucose Uptake. Brain Research 1384:15-22, 2011.
Stuart CA, McCurry MP, Marino A, South MA, Howell MEA, Layne AS, Ramsey MW, Stone MH. Slow-Twitch Fiber Proportion in Skeletal Muscle Correlates with Insulin Responsiveness. J Clin Endocrinol Metab 98:2027-2036, 2013.
Stuart CA, South MA, Lee ML, McCurry MP, Howell MEA, Ramsey MW, Stone MH. Insulin Responsiveness in Metabolic Syndrome after Eight Weeks of Cycle Training. Medicine and Science in Sports and Exercise 45:2021-2029, 2013.
Zhao J, Feng Y, Yan H, Chen Y, Wang J, Chua B, Stuart C, Yin D. beta-arrestin2/miR-155/GSK3beta regulates transition of 5'-azacytizine-induced Sca-1-positive cells to cardiomyocytes. J.Cell Mol.Med. 18(8): 1562-1570, 2014
Li H, Hu D, Fan H, Zhang Y, Lesage GD, Caudle Y, Stuart C, Liu Z, Yin D. beta-Arrestin 2 Negatively Regulates TLR4-Triggered Inflammatory Signaling via Targeting p38 MAPK and IL-10. J.Biol.Chem. 289(33): 23075-23085, 2014