EAST TENNESSEE STATE UNIVERSITY
QUILLEN COLLEGE OF MEDICINE
SUMMARY OF SCHOLARLY ACTIVITIES
Department of Internal Medicine
July 2018 - June 2019
Bah I, Kumbhare A, Nguyen L, McCall CE, El Gazzar M. IL-10 induces an immune repressor
pathway in sepsis by promoting S100A9 nuclear localization and MDSC development. Cell
Immunol. 2018 Oct;332:32-38. doi: 10.1016/j.cellimm.2018.07.003. Epub 2018 Jul 11.
PMID: 30025864
Bhogal S, Khraisha O, Al Madani M, Treece J, Baumrucker S, Paul TK. Emergence of sildenafil as a treatment of pulmonary arterial hypertension and its role as a palliative therapy. Am J Ther. 2019 Mar 29. doi: 10.1097/MJT.0000000000000766. [Epub ahead of print] PMID: 30946047
Bhogal S, Mukherjee D, Bagai J, Truong HT, Panchal HB, Murtaza G, Zaman M, Sachdeva R, Paul TK. Bivalirudin versus Heparin during intervention in Acute Coronary Syndrome: A Systematic Review of Randomized Trials. Cardiovasc Hematol Disord Drug Targets. 2019 Jun 26. doi: 10.2174/1871529X19666190626124057. [Epub ahead of print] PMID: 31241442
Bhogal S, Panchal HB, Bagai J, Banerjee S, Brilakis ES, Mukherjee D, Kumar G, Shanmugasundaram M, Paul TK. Drug eluting versus bare metal stents in saphenous vein graft intervention: An updated comprehensive meta-analysis of randomized trials. Cardiovasc Revasc Med. 2018 Nov 22. pii: S1553-8389(18)30528-1. doi: 10.1016/j.carrev.2018.11.013. [Epub ahead of print] PMID: 30503811
Bibb LA, Winter RP, Leicht SS. Cyclosporine-induced Erythromelalgia. Cureus. 2018 Oct 27;10(10):e3506. doi: 10.7759/cureus.3506. PMID: 30648046
Cao D, Zhao J, Nguyan LN, Nguyen LNT, Khanal S, Dang X, Schank M, Chand Thakuri BK, Wu XY, Morrison ZD, El Gazzar M, Zou Y, Ning S, Wang L, Moorman JP, Yao ZQ. Disruption of Telomere Integrity and DNA Repair Machineries by KML001 Induces T Cell Senescence, Apoptosis, and Cellular Dysfunctions. Front Immunol. 2019 May 22;10:1152. doi: 10.3389/fimmu.2019.01152. eCollection 2019.PMID: 31191531
Chakraborty K, Krishnan S, Joy M. Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii. Nat Prod Res. 2019 May 28:1-12. doi: 10.1080/14786419.2019.1610957. [Epub ahead of print] PMID: 31135235
Ji Y, Dang X, Nguyen LNT, Nguyen LN, Zhao J, Cao D, Khanal S, Schank M, Wu XY, Morrison
ZD, Zou Y, El Gazzar M, Ning S, Wang L, Moorman JP, Yao ZQ. Topological DNA damage,
telomere attrition and T cell senescence during chronic viral infections. Immun
Dai J, Kumbhare A, Williams DA, Youssef D, Yao ZQ, McCall CE, El Gazzar M.Nfia deletion
in myeloid cells blocks expansion of myeloid-derived suppressor cells during sepsis.
Innate Immun. 2018 Jan;24(1):54-65. doi: 10.1177/1753425917742956. Epub 2017 Nov 27.
PMID:29172874
Ageing. 2019 Jun 24;16:12. doi: 10.1186/s12979-019-0153-z. eCollection 2019. PMID:
31285747
Khalid M, Khattak F, Ramu V. Cardiovascular Side Effects of Tyrosine Kinase Inhibitor Ibrutinib (Imbruvica) and Interaction With Direct Oral Anticoagulant. Am J Ther. 2018 Nov/Dec;25(6):e768-e769. doi: 10.1097/MJT.0000000000000775. No abstract available. PMID: 29916856
Khalid MF, Khan AA, Khattak F, Ayub MT, Bagai J, Mukherjee D, Helton T, Cohen MG, Banerjee S, Paul TK. Culprit vessel only versus multivessel percutaneous coronary intervention in acute myocardial infarction with cardiogenic shock: A systematic review and meta-analysis. Cardiovasc Revasc Med. 2018 Dec 21. pii: S1553-8389(18)30618-3. doi: 10.1016/j.carrev.2018.12.015. [Epub ahead of print] PMID:30638891.
Khalid MF, Nukavarapu M, Shah R., Paul TK. Rare case of a kidney and inferior vena cava abnormalities with extensive lower extremity deep vein thrombosis in a young healthy male. Clin Pract. 2018 Oct 26;8(4):1079. doi: 10.4081/cp.2018.1079. eCollection 2018 Oct 26. PMID: 30555668
Khan AA, Panchal H; Zaidi SM, Papireddy M, Mukherjee D, Cohen MG, Banerjee S, Rao S, Pancholy S, Paul TK. Safety and Efficacy of Radial versus Femoral Access for Rotational Atherectomy: A Systematic Review and Meta-Analysis. Cardiovasc Revasc Med 2018. Cardiovasc Revasc Med. 2018 Jun 11. pii: S1553-8389(18)30250-1. PMID: 30030065
Khattak F, Khalid M, Gaddam S, Ramu V, Brahmbhatt V. A Rare Case of Complete Fragmentation of Pacemaker Lead after a High-Velocity Theme Park Ride. Case Rep Cardiol. 2018 Oct 18;2018:4192964. doi: 10.1155/2018/4192964. eCollection 2018. PMID: 30498603
Krishnan S, Chakraborty K, Joy M. First report of chromenyl derivatives from spineless marine cuttlefish Sepiella inermis: Prospective antihyperglycemic agents attenuate serine protease dipeptidyl peptidase-IV. J Food Biochem. 2019 May;43(5):e12824. doi: 10.1111/jfbc.12824. Epub 2019 Mar 13. PMID: 31353519
Lewis PO, Lanier CG, Patel PD, Krolikowski WD, Krolikowski MA. False negative diagnostic errors with polymerase chain reaction for the detection of cryptococcal meningoencephalitis. Med Mycol. 2019 Jun 18. pii: myz064. doi: 10.1093/mmy/myz064. [Epub ahead of print] PMID: 31212317
Lewis PO, Sevinsky RE, Patel PD, Krolikowski MR, Cluck DB. Vancomycin plus nafcillin salvage for the treatment of persistent methicillin-resistant Staphylococcus aureus bacteremia following daptomycin failure: a case report and literature review. Ther Adv Infect Dis. 2018 Sep 10;6:2049936118797404. doi: 10.1177/2049936118797404. eCollection 2019 Jan-Dec. PMID: 30891239
Manthri S, Chakraborty K. Acute parvovirus B19 infection diagnosed by bone marrow
biopsy. BMJ Case Rep. 2019 May 6;12(5). pii: e230403. doi: 10.1136/bcr-2019-230403.
No abstract available. PMID: 31061202
Kou J, Musich PR, Staal B, Kang L, Qin Y, Yao ZQ, Zhang B, Wu W, Tam A, Huang A, Hao
HX, Vande Woude GF, Xie Q. Differential responses of MET activations to MET kinase
inhibitor and neutralizing antibody..PMID:30208970J Transl Med. 2018 Sep 12;16(1):253.
doi: 10.1186/s12967-018-1628-y.
McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M."Myeloid
Cell-Specific Knockout of NFI-A Improves Sepsis Survival". Infect Immun. 2018 Feb
20;86(3). pii: e00820-17. doi: 10.1128/IAI.00820-17. Print 2018 Mar. No abstract PMID:29463685
Moorman JP, Krolikowski MR, Mathis SM, Pack RP. HIV/HCV Co-infection: Burden of Disease
and Care Strategies in Appalachia. Curr HIV/AIDS Rep. 2018 Aug;15(4):308-314. doi:
10.1007/s11904-018-0404-1. Review. PMID: 29931466
Murtaza G, Virk HUH, Khalid M, Lavie CJ, Ventura H, Mukherjee D, Ramu V, Bhogal S, Kumar G, Shanmugasundaram M, Paul TK. Diabetic cardiomyopathy - A comprehensive updated review. Prog Cardiovasc Dis. 2019 Mar 25. pii: S0033-0620(19)30051-9. doi: 10.1016/j.pcad.2019.03.003. [Epub ahead of print] Review. PMID: 30922976
Nguyen KPL, Pai V, Rashid S, Treece J, Moulton M, Baumrucker SJ. Prognostication in Anoxic Brain Injury. Am J Hosp Palliat Care. 2018 Nov;35(11):1446-1455. doi: 10.1177/1049909118767881. Epub 2018 Apr 3. Review. PMID: 29614864
Nguyen LN, Zhao J, Cao D, Dang X, Wang L, Lian J, Zhang Y, Jia Z, Wu XY, Morrison Z, Xie Q, Ji Y, Zhang Z, El Gazzar M, Ning S, Moorman JP, Yao ZQ. Inhibition of TRF2 accelerates telomere attrition and DNA damage in naïve CD4 T cells during HCV infection. Cell Death Dis. 2018 Sep 5;9(9):900. doi: 10.1038/s41419-018-0897-y. PMID: 30185784
Shipley LC, Taylor ST, Grimsley C, Stoffer K, Goldstein J. Rats! Hantavirus: A Case Report of a Suspected Case in Eastern Tennessee. Perm J. 2018 Jul 19;22:17-222. doi: 10.7812/TPP/17-222. PMID: 30010530
Sitwala P, Khalid MF, Khattak F, Bagai J, Bhogal S, Ladia V, Mukherjee D, Daggubati R, Paul TK. Percutaneous closure of patent foramen ovale in patients with cryptogenic stroke - An updated comprehensive meta-analysis. Cardiovasc Revasc Med. 2018 Sep 19. pii: S1553-8389(18)30412-3. doi: 10.1016/j.carrev.2018.09.010. [Epub ahead of print]. PMID: 30282597
Taha Y, Patel R AG, Bagai J, Sachdeva R, Kumar G, Prasad A, Nathan S, Paul TK. Percutaneous coronary intervention versus coronary artery bypass grafting in treatment of unprotected left main stenosis. Curr Cardiol Rep. 2019 Mar 18;21(5):27. doi: 10.1007/s11886-019-1113-0. Review. PMID: 30880360.
Treece J, Tawadros F, Josan E. Asystole Due to Spontaneous Hemopericardiac Tamponade in a Patient on Warfarin. Am J Ther. 2018 Sep/Oct;25(5):e598-e599. doi: 10.1097/MJT.0000000000000612. No abstract available. PMID: 30188877
Wang L, Cao D, Wang L, Zhao J, Nguyen LN, Dang X, Ji Y, Wu XY, Morrison ZD, Xie Q, El Gazzar M, Ning S, Moorman JP, Yao ZQ. HCV-associated exosomes promote myeloid- derived suppressor cell expansion via inhibiting miR-124 to regulate T follicular cell differentiation and function.PMID:30210805
Youssef DA, El-Fayoumi HM, Mahmoud MF. Beta-caryophyllene protects against diet- induced
dyslipidemia and vascular inflammation in rats: Involvement of CB2 and PPAR-γ
Wang L, Howell MEA, McPeak B, Riggs K, Kohne C, Yohanon JU, Foxler DE, Sharp TV, Moorman
JP, Yao ZQ, Ning S. LIMD1 is induced by and required for LMP1 signaling, and protects
EBV-transformed cells from DNA damage-induced cell death. Oncotarget. 2017 Dec 26;9(5):6282-6297.
doi: 10.18632/oncotarget.23676. eCollection 2018 Jan 19. PMID:29464072
receptors. Chem Biol Interact. 2019 Jan 5;297:16-24. doi: 10.1016/j.cbi.2018.10.010.
Epub 2018 Oct 19. PMID: 30343038
Zhou Y, Li H, Siddiqui N, Caudle Y, Zhang H, Elgazzar M, Yin D. Hematopoietic stem progenitor cells prevent chronic stress-induced lymphocyte apoptosis. Journal of Neuroimmunology. 2017 Aug 15;309:72-76. PMID:28601292
II. PAPERS AND ABSTRACTS
γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport; Victoria E. Palau1, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon,William Stone and Koyamangalath Krishnan; published in BMC Cancer (2018) 18:564 https://doi.org/10.1186/s12885-018-4462-y.
S100A9 maintains myeloid-derived suppressor cells in chronic sepsis by inducing miR-21 and miR-181b. Alkhateeb T, Bah I, Kumbhare A, Youssef D, Yao ZQ, McCall CE, and El Gazzar M. Molecular Immunology 2019; 112:72-81.
Interesting Case of Leptospirosis Presenting as Jaundice and Acute Renal Failure in North East Tennessee. Khan I, Khalid M, Moorman J, Ibrahim L, Youssef D. J Microbiol Infect Dis. 2018; 8(2):80-82.
IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development. Bah I, Kumbhare A, Nguyen L, McCall CE, and El Gazzar M. Cellular Immunology 2018; 332:32-38.
Fibrosing Mediastinitis: Uncommon Life-threatening Complication of Histoplasmosis. Khalid M, Khan I, Rahman Z, Alazzeh A, Youssef D. Cureus 10(4):e2 532. Doi:10.7759/cureus.2532 (April 25, 2018).
Continuous Infusion Ampicillin for the Outpatient Management of Enterococcal Endocarditis: a Case Report and Literature Review. Lewis PO, Jones A, Amodei RJ, Youssef D. Journal of Pharmacy Practice 2018 Oct 16:897190018804964. DOI:10.1177/0897190018804964.
Correction for McPeak et al., “Myeloid Cell-Specific Knockout of NFI-A Improves Sepsis Survical”. McPeak MB, Youssef D, Williams DA, Pritchett C, Yao ZQ, McCall CE, El Gazzar M. Infect Immun. 2018 Feb 20;86(3). pii: e00820-17. doi: 10.1128/IAI.00820-17. Print 2018 Mar.
Actinomyces turicensis Bacteremia Presenting with Empyema of Lung: A Case Report. Yorke J, Karakattu S, Youssef D and El-Abbassi A. J Health Sci Educ. Vol 3(2): 1-4
Acute parvovirus B19 infection diagnosed by bone marrow biopsy, S Manthri MD, K Chakraborty
MD; Division of Oncology, Department of Medicine, Quillen College of Medicine, ETSU,
Johnson City TN; Published in BMJ Case Reports CP 2019; 12: e230403. (https://casereports.bmj.com/content/12/5/e230403.info)
Zhao J, Dang X, Zhang P, Nguyen LN, Cao D, Wang L, Wu X, Morrison ZD, Zhang Y, Jia
Z, Xie Q, Wang L, Ning S, El Gazzar M, Moorman JP, Yao ZQ. Insufficiency of DNA repair
enzyme ATM promotes naive CD4 T-cell loss in chronic hepatitis C virus infection.
Cell Death Dis. 2018 Sep 5;9(9):900. doi: 10.1038/s41419-018-0897-y. PMID:29644094
III. POSTER PRESENTATIONS
A Rare Case of Non-Producing Primary Plasma Cell Leukemia; S Manthri MD, K Chakraborty MD, (First Place); Division of Oncology, Department of Medicine, Quillen College of Medicine, ETSU, Johnson City TN; presented at Appalachian Student Research Forum in 2019.
An association between smoking status and homocysteine levels and whether this association is modified by sex hormones and cholesterol. Awasthi M, Omoike E, Paul TK, Ridner S, Mamudu H. Appalachian Student Research Forum, Johnson City, April 2019.
An unusual case of myxedema coma presenting as severe bradycardia and hypotension secondary to pituitary apoplexy. Bhogal S, Bhandari T, Mawa K, Paul TK J Investig Med, February 2019
An unusual case of myxedema coma presenting as severe bradycardia and hypotension secondary to pituitary apoplexy. Bhogal S, Bhandari T, Mawa K, Paul TK. Southern Society for Clinical Investigation, Southern Regional Meeting, New Orleans 2019.
Association of age, gender and race in chronic kidney disease patients and without dialysis. Onatolu BA, Panchal H, Francis L, Zheng S, Paul TK. Appalachian Student Research Forum, Johnson City, April 2019.
ATM gene Deletion: A Rare Etiology for Hereditary Cancers by Nina S. Appareddy, Sukesh Manthri, Fady Tawadros, Kimberly Helms, Elnora Spradling-Regional Appalachian Research Student Forum, Johnson City, TN, 4/12/2019
Atrial septal endocarditis complicating tricuspid valve endocarditis. Cardiovascular Innovations Khalid MF, Sivagnanam K, Shams W, Ramu V, Paul TK Meetings 2018, Denver, CO.
Culprit Vessel Only versus Multivessel Percutaneous Coronary Intervention in Acute ST Elevation Myocardial Infarction with Cardiogenic Shock: A Comprehensive Updated Meta- Analysis. Transcatheter Cardiovascular Therapeutic (TCT) Khalid M, Khan AA, Khattak F, Ayub M, Bagai J, Helton T, Paul TK. Scientific Conference 2018, San Diego, CA
Culprit Vessel Only versus Multivessel Percutaneous Coronary Intervention in Acute ST Elevation Myocardial Infarction with Cardiogenic Shock: A Comprehensive Updated Meta- Analysis. Khalid M, Khan AA, Khattak F, Ayub M, Bagai J, Helton T, Paul TK. J Am Coll Cadiol 2018.
Drug Eluting Stents versus Bare Metal Stents in Saphenous Vein Graft Percutaneous Coronary Intervention: An Updated Comprehensive Meta-analysis. Cardiovascular Innovations Bhogal S, Panchal H, Paul TK. Meetings 2018, Denver, CO.
Follicular lymphoma masquerading as cholecystitis and pancreatitis; S.Singal, MD; A.Mansurov, MD; A.Patel, MD; K.Chakraborty, MD; D.Jaishankar, MD; Division of Oncology, Department of Medicine, Department of Pathology, Quillen College of Medicine, ETSU, Johnson City TN; presented at Southern Regional Meeting- Southern Society Clinical Investigation 2018
Identifying multiple risk factors of hypertension for reducing the prevalence of peripheral
arterial disease in rural Central Appalachia. Odebunmi OO, Orimaye SO, Mokikan MT,
Awuujoola AO, Oke AO, Poole AM, Paul TK, Alamian A, Stewart D, Mamudu HM. Appalachian
Student Research Forum, Johnson City, April 2019.
Individual and contextual factors associated with sub-clinical atherosclerosis in
diabetes patients in rural Central Appalachia. Osedeme F, Orimaye SO, Jones A, Paul
TK, Blackwell J, Budoff M, Mamudu H. American Public Health Association. November
2018.
Left anterior descending artery aneurysm associated with stent restenosis following drug eluting stent implantation. Sitwala P, Khalid MF, Ladia V, Helton T, Paul TK. Tennessee ACC chapter. Nashville, TN 2018.
Leptomeningeal involvement by prostate cancer - strike by an ominous hydra; Fady Tawadros 1 M.D , Sukesh Manthri M.D, , Maria Zayko , DO, Devapiran Jaishankar M.D, Kanishka Chakraborty M.D, FACP; Division of Oncology, Department of Medicine, Department of Pathology, Quillen College of Medicine, ETSU, Johnson City TN; Presented at Southern Regional Meeting- Southern Society Clinical Investigation 2018
Long time response with Ado-trastuzumab emtansine (T-DM1) in a recurrent metastatic breast cancer; Sukesh Manthri, MD1; Sakshi Singal, MD; Bahaaeldin Youssef, MD; Kanishka Chakraborthy, MD, FACP; Division of Oncology, Department of Medicine, Department of Pathology, Quillen College of Medicine, ETSU, Johnson City TN; Presented at Southern Regional Meeting- Southern Society Clinical Investigation 2018.
Metastatic basal cell carcinoma masquerading as triple negative breast cancer; S.Singal, MD; A.Mansurov, MD; H.Mejbel, MD; K.Chakraborty, MD; D.Jaishankar, MD; Division of Oncology, Department of Medicine, Department of Pathology, Quillen College of Medicine, ETSU, Johnson City TN; presented at Southern Regional Meeting- Southern Society Clinical Investigation 2018.
NOACs vs Warfarin for Atrial Fibrillation Catheter Ablation: A Meta-Analysis. Bhogal S, Bhandari T, Kohli V, Bhattad V, Papireddy M, Paul TK, Ramu V. American College of Cardiology March 2019, New Orleans, LA.
Not Your Regular Run-of-the-Mill Bladder Cancer; H Rehman MD, K Chakraborty MD, (Second Place); Division of Oncology, Department of Medicine, Quillen College of Medicine, ETSU, Johnson City TN; presented at Appalachian Student Research Forum in 2019.
Pancytopenia- A Rare Manifestation of Isolated Folate Deficiency in Pregnancy by Sukesh Manthri, Haroon Rehman, Emily Paterson, Elnora Spradling- Southern Regional Meeting, New Orleans, LA 2/21/2019
Prevalence, trends, and association of obesity and dyslipidemia among U.S. Youth: 1999- 2012. Owusu D, Wang K, Paul TK, Wang L. Obesity Week 2018 in Nashville, TN.
Re-visiting Thrombolysis in Myocardial infarction (TIMI) Risk Score in the Current era of Newer Antiplatelets. Zaidi S, Khalid M, Bhogal S, Alkawaleet Y, Khan AA, Paul TK. Cardiovascular Innovations Meetings 2018, Denver, CO
Safety and efficacy of direct oral anticoagulation versus warfarin for atrial fibrillation catheter Ablation: A Meta-Analysis. Bhogal S, Bhandari T, Kohli V, Bhattad V, Papireddy M, Paul TK, Ramu V. American College of Cardiology March 2019, New Orleans, LA.
Systemic mastocytosis with associated chronic myelomonocytic leukemia; F Tawadros,
MD; K Chakraborty, MD; Division of Oncology, Department of Medicine, Quillen College
of Medicine, ETSU, Johnson City TN; presented at Appalachian Student Research Forum
in 2018.
Ungodly act of janus kinase; Nina Amilineni MD, Fady Tawadros MD, Kanishka Chakraborty
MD; Division of Medical Oncology/Hematology, Department of Internal Medicine, East
Tennessee State University Quillen College of Medicine; Division of Oncology, Department
of Medicine, Quillen College of Medicine, ETSU, Johnson City TN; Presented at Southern
Regional Meeting- Southern Society Clinical Investigation 2018.
When cure is in sight, Trolling of cancer resumes; A.Mansurov MD, H.Rehman MD, R. Zafar MD, D. Jaishankar MD, K. Chakraborty MD; Division of Oncology, Department of Medicine, Department of Pathology, Quillen College of Medicine, ETSU, Johnson City TN; Presented at Southern Regional Meeting- Southern Society Clinical Investigation 2018
EDITORIALS, WEB PAGES, LETTERS, WHITE PAPERS, Other (Non-Peer-Reviewed) None
INVITED PRESENTATIONS
Krishnan K. "Recent advances in Acute myeloid Leukemia” at the Institute of Medical
Education and Research. (PGI), Chandigarh, India on January 22, 2019
BOOKS OR BOOK CHAPTERS
Paul TK. Pharmacogenomics and drug-drug interaction. 1133 Questions: An Interventional Cardiology Board Review. Third edition. Editors: Debabrata Mukherjee et al. Wolters Kluwer 2019.